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Sepsis (with mechanical ventilation) treated by 5days of 50,000 IU of Vitamin D – RCT May 2024

Outcomes of High-Dose Versus Low-Dose Vitamin D on Prognosis of Sepsis Requiring Mechanical Ventilation: A Randomized Controlled Trial

J Intensive Care Med . 2024 May 5:8850666241250319. doi: 10.1177/08850666241250319 PDF behind paywall, but in DeepDyve
Tarek Mohamed Ashoor 1, Abd Elmoniem Hassan Abd Elazim 2, Zakaria Abd Elaziz Mustafa 1, Maha Ahmad Anwar 3, Ihab Ahmad Gad 1, Ibrahim Mamdouh Esmat 1



Background: Critically ill patients with sepsis have a high incidence of vitamin D deficiency. Vitamin D promotes the synthesis of human cathelicidin antimicrobial peptide, a precursor of LL-37, which is a part of the innate immune system. This study investigated the effectiveness and safety of the early administration of high-dose enteral vitamin D3 in comparison with low-dose vitamin D3 in patients with sepsis requiring mechanical ventilation (MV).

Methods: Eighty adult patients with sepsis requiring MV with known vitamin D deficiency were randomly assigned to receive either an enteral 50 000 IU (Group I) or 5000 IU (Group II) vitamin D supplementation. Clinical and laboratory parameters were evaluated at baseline and on days 4 and 7 between the study groups. The change in serum procalcitonin (PCT) levels on day 7 was the primary outcome, while the change in serum LL-37 levels on day 7, changes in sequential organ failure assessment (SOFA) score, and clinical pulmonary infection score on day 7, MV duration, and hospital length of stay (LOS) were the secondary outcomes.

Results: The (day 7-day 0) change in serum PCT and LL-37 levels and SOFA score were significantly different in Group I (P = .010, P < .001, and P < .001, respectively). The SOFA score was significantly different on days 4 and 7 in Group I (P < .001 and P < .001, respectively). The incidence of early ventilator-associated pneumonia was significantly different between both treatment groups (P = .025). The hospital LOS was shorter in Group I (P < .001). No 25-hydroxyvitamin-D toxicity was observed in either group.

Conclusions: Early enteral administration of high-dose vitamin D3 in critically ill patients with sepsis requiring MV along with standard treatment for sepsis decreased serum procalcitonin levels, increased serum LL-37 levels, and ameliorated illness severity scores.

My 102 year-old father-in-law was in ICU with Sepsis, I gave him 200,000 IU, he was kicked out of ICU 3 days later

His doctors wondered how he recovered to quickly. I never told them.

VitaminDWiki – Sepsis is both prevented and treated by Vitamin D contains:

Attached files

ID Name Comment Uploaded Size Downloads
21183 Sepsis LOS.webp admin 06 May, 2024 31.28 Kb 18
21182 Sepsis levels.webp admin 06 May, 2024 9.00 Kb 18
21180 SOFA.webp admin 06 May, 2024 7.83 Kb 20