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Obese children had 2.2 X less response to a single dose of Vitamin D – Oct 2020

Response to single oral dose vitamin D in obese vs non-obese vitamin D-deficient children

Eur J Pediatr . 2020 Oct 12. doi: 10.1007/s00431-020-03831-0
Akshay Tayde 1, Medha Mittal 2, Rajesh Khadgawat 3, Shikha Sharma 4, V Sreenivas 5, Anuradha Rai 1


Suspect that obese children would need about 3X large dose to get the same response
On-line Vitamin D response simulation – July 2021
VitaminDWiki page titles containing "RESPONSE" 127 pages as of Oct 2021
Items in both of the categories of Infant/Child AND Obesity

Overview Obesity and Vitamin D contains the following summary

Obese need more Vitamin D

  • Normal weight     Obese     (50 ng = 125 nanomole)

Click here for 2014 study


  • Normal weight     Obese     (50 ng = 125 nanomole)

Obesity is associated with low Vitamin D (and treated by D as well) – Aug 2019 has the following

Fast weight loss by Obese Adults: Summary of the data as of Sept 2019
1) 50,000 IU Vitamin D weekly for at least 6 months
   If gut problems, should use a gut-friendly form of vitamin D
2) Add calorie restriction diet and light exercise after ~2 months*
   * Vitamin D levels must be above 30ng/ml to help with weight loss
   * Start losing weight 2 months sooner if take a 50,000 IU daily for a week
3) More weight loss if also add Magnesium or cofactors
   30% Improved Vitamin D response with Magnesium - a Vitamin D Cofactor
   Note: Magnesium reduces weight loss by itself as well
   20% improved vitamin D response if also add Omega-3 a Vitamin D Cofactor
  Note: Omega-3 reduces weight loss by itself as well
4) More weight loss if also improve activation of Vitamin D Receptor
   Vitamin D Receptor activator: 0-30% improved Vitamin D response
   Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019
Update Dec 2019 - Dr. Greger plant-based eating (not diet) for both weight loss and health.
  His book does not mention Vitamin D nor Adenovirus

 Download the PDF from sci-hub via VitaminDWiki

Obese individuals are prone to vitamin D deficiency because of sequestration of vitamin D in their body fat. We planned to evaluate the rise in serum 25(OH)D levels in vitamin D-deficient obese vs normal body mass index(BMI) children, after administration of identical single dose of vitamin D. Twenty-two obese and 22 normal BMI children with serum 25 (OH)D < 20 ng/mL were given single oral dose 150,000 IU vitamin D, and 25 (OH)D levels were measured at 1 week and 1 month post-intervention.

Results show that rise in 25(OH)D level from baseline was about 2.2 times lesser in obese compared with children with normal BMI, both at 1 week and at 1 month. The rise in 25(OH)D from baseline to 1 month was inversely correlated to BMI (r = - 0.56, p = < 0.001), waist circumference (r = - 0.48, p = 0.001), total fat mass (r = - 0.58, p < 0.001), and fat mass index (r = - 0.59, p < 0.001).

Conclusion: The obese children have a 2.2 times lower rise in serum vitamin D levels as compared with the normal BMI children for the same dose of vitamin D supplementation. What is Known: • The obese individuals are prone to vitamin D deficiency and may be given higher doses of vitamin D supplementation. What is New: • Our study demonstrates that obese children have 2.2 times lesser rise in serum 25(OH)D concentrations as compared with normal BMI children when administered similar oral dose vitamin D.

Created by admin. Last Modification: Sunday October 24, 2021 00:40:27 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
14428 Obese children.jpg admin 14 Oct, 2020 48.96 Kb 335
14426 Obese children 2.2 X less response sci-hub.pdf admin 14 Oct, 2020 462.09 Kb 327