Modulating effect of vitamin D status on serum anti-adenovirus 36 antibody amount in obese children: National Food and Nutrition Surveillance
BMC Pediatrics, DOI:10.21203/rs.2.16332/v1
Bahareh Nikooyeh, Bruce Hollis, Tirang Reza Neyestani
Subset of table
Items in both categories Obesity and Virus are listed here:
- COVID-19 hospitalizations: 63% associated with diabetes, obesity, hypertension or heart failure – Feb 2021
- Light case of COVID-19 in immunocompromised obese man with many comordities but good level of vitamin D – March 2021
- Obese get less benefit from vaccines: influenza, hepatitis B, rabies and now COVID-19 - March 2021
- 26 health factors increase the risk of COVID-19 – all are associated with low vitamin D
- Virus (adeno-36) increases Obesity which then increases risk of another virus (Influenza) - Oct 2013
- Increased weight in children 8X more likely for each unit increase in adenovirus (if ignore Vitamin D) – Nov 2019
- 25 year review of Adenovirsus and obesity – 2018
- Adenovirus-36 is strongly associated with Obesity (possibly prevented and treated by Vitamin D)
- Adenovirus-36 association with obesity letter to editor – 2011
- Obesity pandemic since 1975 - is it due to Vitamin D, Magnesium, Iodine, adenovirus, or what
- Low vitamin D then Obesity then adenovirus-36
Background. Among the causative factors of obesity, a rather newly proposed theory is viral infections. The association of ADV-36 infection and obesity has been reported by some research groups in children. We hypothesized that the association between ADV-36 infection and adiposity may be mediated by sub-optimal vitamin D status of the host. To examine this hypothesis, we conducted a case control study on children and adolescents with normal weight, over weight and obesity.
Methods. In total, 91 (normal weight: 33, overweight: 33, obese: 25) apparently healthy children aged 5-18 years were randomly selected from the registered population at National Food and Nutrition Surveillance Program (NFNS). The groups were matched based on age and sex. Anthropometric, biochemical and serological assessments were performed.
Results. The amount of anti-ADV36-Ab increased whereas circulating concentrations of calcidiol decreased across BMI categories with higher amounts in normal weight than in overweight and obese children (31.0±16.4, 22.5±10.5 and 21.9±9.8 nmol/L, respectively, p=0.004).
Logistic regression analysis revealed that for each unit increment of anti-ADV36-Ab, the chance of increase in weight was 8.5 times (OR: 8.5, p=0.029). Interestingly, when 25(OH)D was introduced into the model, anti-ADV36-Ab was no longer the predictor of weight increment and the chance of increase in weight reduced 5% for each unit increase in calcidiol concentration (OR: 0.95, p=0.012).
Conclusion. It is suggested that ADV36-induced lipogenesis and weight gain may be mediated by vitamin D deficiency in obese children. Further studies are warranted.