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More Hypertension in obese children with low vitamin D, especially at night – Dec 2013

Hypovitaminosis D and nocturnal hypertension in obese children: an interesting link.

J Hum Hypertens. 2013 Dec 5. doi: 10.1038/jhh.2013.122.
Banzato C, Maffeis C, Maines E, Cavarzere P, Gaudino R, Fava C, Minuz P, Boner A, Antoniazzi F.
Department of Life and Reproduction Sciences, Section of Pediatrics, University of Verona, Verona, Italy.

In adults, low levels of vitamin D are associated with hypertension. The aim of this study was to evaluate the relationship between 24-h blood pressure (BP) patterns and vitamin D levels in obese children. We recorded anthropometric parameters, took blood samples for 25-hydroxivitamin D measurements and monitored ambulatory BP (ABP) in 32 obese children (male/female: 21/11, age 7-16 years).
Subjects in the lower tertiles had

  • higher homeostasis model assessment of insulin resistance,
  • nighttime systolic and diastolic ABP,
  • nighttime systolic and diastolic ABP load,
  • 24-h ABP index and nighttime systolic and
  • diastolic ABP index than those in the higher tertile.

Vitamin D correlated negatively with

  • 24-h and nighttime systolic ABP,
  • 24-h systolic ABP load,
  • nighttime systolic and diastolic ABP load,
  • 24-h systolic ABP index and nighttime systolic ABP index.

The percentage of subjects with pathological 24-h systolic BP (SBP) load, nighttime SBP load, nighttime diastolic BP (DBP) load, nighttime SBP index and nighttime DBP index increased progressively as the vitamin deficiency categories increased (χ2=10.26, P<0.05; χ2=16.34, P<0.01; χ2=10.23, P<0.05; χ2=10.38 and χ2=10.06, P <0.01). Low levels of vitamin D in obese children were associated with a higher BP burden, especially at night.

PMID: 24304709

Wonder why there is more beneft from higher vitamin D at night.

Wonder if there is a similar benefit to obese adults

Wonder if this is the reason that vitamin D helps reduce COPD in adults (at night)

See also VitaminDWiki