Associations between vitamin D status in infants and blood lipids, body mass index and waist circumference.
Acta Paediatr. 2011 Mar 18. doi: 10.1111/j.1651-2227.2011.02273.x.
Arnberg K, Ostergård M, Madsen A, Krarup H, Michaelsen K, Mølgaard C.
Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark Department of Clinical Biochemistry, Aalborg Hospital, Denmark.
Aim:? To study the relationships between 25-hydroxyvitamin D status and blood lipids, insulin, glucose, body mass index and waist circumference in infants. Methods:? In a cross sectional study, 255 infants aged 9 months with a blood sample for 25-hydroxyvitamin D were examined. Plasma 25-hydroxyvitamin D concentrations were analysed by chemiluminescent immunoassay. Associations between plasma 25-hydroxyvitamin D and high density lipoprotein, low density lipoprotein, total cholesterol, triglycerides, insulin, glucose, body mass index and waist circumference were analysed. Results:? Mean plasma 25-hydroxyvitamin D was 77.2 ± 22.7 nmol/L. At the time of examination, 97% received vitamin D supplementation. 25-hydroxyvitamin D was negatively associated with high density lipoprotein (P=0.003), cholesterol (P=0.002) and triglycerides (P=0.010) in multivariate analysis controlled for gender, season, body mass index, length, birth weight and breastfeeding.
There were no associations between 25-hydroxyvitamin D and glucose or insulin (all P>0.05). 25-hydroxyvitamin D was negatively associated with body mass index (P=0.005) and waist circumference (P=0.002) controlled for gender, season, breastfeeding, birth weight and length.
Conclusion:? Vitamin D status is negatively associated with blood lipids, body mass index and waist circumference in infants where nearly all received vitamin D supplements. Whether this has long term health effects remains to be elucidated.
Acta Paediatrica © 2011 Foundation Acta Paediatrica.
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