Helicobacter pylori infection and low vitamin D – several studies

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Helicobacter pylori infection 11 X more likely if low vitamin D – meta-analysis Aug 2019

Effect of vitamin D on Helicobacter pylori infection and eradication: A meta-analysis
Helicobacter. 2019 Aug 14:e12655. doi: 10.1111/hel.12655.
Yang L1, He X1, Li L1, Lu C1.
Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
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BACKGROUND:
Various studies reported the relationship between Helicobacter pylori (H pylori) and vitamin D, but there is some controversy around that. This study aimed to conduct a meta-analysis to clarify the relationship between vitamin D and H pylori infection, and vitamin D and H pylori eradication.

METHODS:
Articles published until June 1, 2019, in the PubMed, MEDLINE, and EMBASE databases with English-language medical studies were searched. According to the inclusion criteria, relevant statistical data were extracted to Microsoft Excel and analyzed by STATA15.1.

RESULTS:
Ten articles were finally included. It was demonstrated that average 25(OH)D level in H pylori-positive patients was lower than H pylori-negative (SMD = -0.53 ng/mL, 95% CI = (-0.91, -0.16 ng/mL)). For H pylori eradication individuals, the result showed that average 25(OH)D level in H pylori successful eradication individuals was higher than unsuccessful (SMD = 1.31 ng/mL, 95% CI = [0.60, 2.02 ng/mL]).
In addition, individuals with vitamin D deficiency had lower H pylori eradicate rate (OR = 0.09, 95% CI = [0.02, 0.41]). Sensitivity analysis showed that the meta-analysis results were stable and reliable.

CONCLUSIONS:
Vitamin D was a protective factor to H pylori infection. Moreover, vitamin D can improve the success rate of H pylori eradication.

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Study was cited 22 times as of Dec 2022

• Vitamin D and Gastric Cancer: A Ray of Sunshine? - Sept 2021 DOI: 10.7759/cureus.18275 FREE PDF

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Helicobacter pylori reduced in mice by vitamin D – Dec 2022

Vitamin D3 eradicates Helicobacter pylori by inducing VDR-CAMP signaling
Front Microbiol . 2022 Dec 8;13:1033201. doi: 10.3389/fmicb.2022.1033201. eCollection 2022.
Ye Zhang 1, Chunya Wang 1, Li Zhang 1, Jie Yu 2, Wenjie Yuan 1, Lei Li 1

Background: Vitamin D3 [VitD3, 1,25 (OH)2D3] is known to have immunomodulatory and anti-microbial properties; however, its activity against Helicobacter pylori is unclear. In this study, we established H. pylori infection models in wild-type and VitD3 receptor (VDR) knockdown mice and analyzed the effects of VitD3 and their underlying mechanisms.

Methods: VDR+/+ and VDR+/- mice were intragastrically infected with the H. pylori SS1 strain. After confirmation of H. pylori infection, mice were treated with different doses of VitD3. The infection levels in stomach tissues were quantified using the colony-forming assay, and the expression levels of the VDR and cathelicidin antimicrobial peptide (CAMP) in the gastric mucosa were analyzed by immunohistochemistry and western blotting.

Results: The gastric mucosa of VDR+/- mice was more susceptible to H. pylori colonization and had lower levels of VDR and CAMP expression than that of VDR+/+ mice. H. pylori infection upregulated VDR and CAMP expression in the stomach of both wild-type and mutant mice, and VitD3 treatment resulted in further increase of VDR and CAMP levels, while significantly and dose-dependently decreasing the H. pylori colonization rate in both mouse groups, without affecting blood calcium or phosphorus levels.

Conclusion: Our data indicate that oral administration of VitD3 reduces the H. pylori colonization rate and upregulates VDR and CAMP expression in the gastric mucosa, suggesting a role for VitD3/VDR/CAMP signaling in the eradication of H. pylori in the stomach. These findings provide important insights into the mechanism underlying the anti-H. pylori activity of VitD3 and should be useful in the development of measures to eradicate H. pylori.
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Vitamin D3 Inhibits Helicobacter pylori Infection by Activating the VitD3/VDR-CAMP Pathway in Mice - Oct 2020

Front. Cell. Infect. Microbiol., 23 October 2020 | https://doi.org/10.3389/fcimb.2020.566730
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Anni Zhou1†, Lei Li2†, Guiping Zhao1, Li Min1, Si Liu1, Shengtao Zhu1, Qingdong Guo1, Chunjie Liu3, Shutian Zhang1* and Peng Li1*

Helicobacter pylori (H. pylori) infection is closely associated with the occurrence and development of gastric diseases. Therefore, eliminating H. pylori infection should help to prevent gastric diseases. Vitamin D3 (VitD3, 1,25(OH)2D3) was previously observed to exhibit anti-H. pylori infection activity in clinic, but these results were reported in heterogeneous in vivo studies without elucidation of the underlying mechanisms. In the present study, we established H. pylori infection models in both wild-type and VDR knockdown (VDR-KD) mice, which were used to demonstrate that VitD3 inhibits H. pylori infection by enhancing the expression of VitD receptor (VDR) and cathelicidin antimicrobial peptide (CAMP). Furthermore, VDR-KD mice that exhibited lower VDR expression were more susceptible to H. pylori infection. In cultured mouse primary gastric epithelial cells, we further demonstrated that the VitD3/VDR complex binds to the CAMP promoter region to increase its expression. These data provide a mechanistic explanation of the anti-H. pylori infection activity of VitD3 at the molecular level in mice and suggest a new avenue for the clinical management of H. pylori eradication therapy.

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The effect of vitamin D deficiency on eradication rates of Helicobacter pylori infection – Oct 2018

JGH Open. 2018 Dec; 2(6): 270–275. doi: 10.1002/jgh3.12081, PMCID: PMC6308038. PMID: 30619936
Mohamed S El Shahawy,corresponding author 1 Mahmoud H Hemida, 2 Ibrahim El Metwaly, 3 and Zakarya M Shady 4

Background/Aim
Many studies have investigated risk factors other than antibiotic resistance linked to Helicobacter pylori (H. pylori) eradication failure. The aim of this study was to study the effect of serum levels of 25‐hydroxy‐vitamin D (25OHD) on eradication rates of H. pylori infection.

Methods
This study included 150 patients diagnosed with H. pylori gastritis using magnifying narrow‐band imaging endoscopy supported by stool antigen test. Serum 25‐OH vitamin D levels were measured via the Enzyme‐Linked Immune Sorbent assay (ELISA) method before starting eradication therapy of H. pylori infection. All patients were treated with clarithromycin‐based triple therapy for 14 days. H. pylori eradication was determined via a stool antigen test performed 4 weeks after the end of therapy. According to the serum level of 25‐OH vitamin D levels, the patients were divided into two groups: group I (sufficient) had a vitamin D level of ≥20 ng/mL, while group II (deficient) had a vitamin D level of <20 ng/mL.

Results
Our results revealed that eradication was successful in 105 (70%) patients and failed in 45 (30%) patients. The mean 25OHD level was significantly lower in the eradication failure group compared to the successful treatment group (14.7 ± 4.5 vs 27.41 ± 7.1; P < 0.001). Furthermore, there were significantly more patients with deficient 25OHD levels in the failed treatment group, 30 (66.6%), compared to the successful group, 10 (9.5%) (P < 0.001).

Conclusions
Our results demonstrated that 25‐OH vitamin D deficiency may be considered a risk factor related to eradication failure of H. pylori infection. In addition, a further randomized trial to evaluate the effect of vitamin D supplementation in H. pylori eradication is mandatory.
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Helicobacter pylori Eradication: 88% if high vitamin D vs 38% if low - Feb 2021

Is Vitamin D Deficiency a Risk Factor for Helicobacter Pylori Eradication Failure?
Clin Lab . 2021 Feb 1;67(2). doi: 10.7754/Clin.Lab.2020.200118.
Mokhtar M Shatla, Ahmed S Faisal, Mahmoud Z El-Readi

Background: Host factors related to failure of eradication of Helicobacter pylori (H. pylori) are increasingly studied. This work aimed to study the influence of 25-hydroxy-vitamin D 25(OH)-vitD status on the rate of H. pylori eradication.

Methods: One hundred and fifty patients infected with H. pylori were tested for serum 25(OH)-vitD level prior to 14 days clarithromycin-based triple eradication therapy. Accordingly, patients were divided into: group I (eradication successful) and group II (eradication failure). Both groups were compared regarding mean level of serum 25(OH)-vitD and number and percentage of patients with deficient 25 (OH)-vitD.

Results: Overall rate of eradication was 72%. Mean serum level of 25(OH)-vitD was higher in the eradication successful group compared to the group of eradication failure (28.12 ± 8.10 vs. 13.54 ± 6.37; p < 0.001). The percentage of patients with 25(OH)-vitD deficiency was higher in the group of eradication failure compared to the group of successful eradication [30 (71.5%) vs. 19 (17.5%); p < 0.001]. Patients with sufficient 25(OH)-vitD had a higher rate of eradication compared to patients with deficient 25(OH)-vitD (88% vs. 38.5%).

Conclusions: This study suggested that deficiency of 25(OH)-vitD could be a risk factor for H. pylori eradication failure, and it recommends to investigate the effect of vitamin D supplementation on H. pylori eradication.

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Several micronutrients (such as Vit D) enable the immune system to fight Helicobacter pylori - March 2022

The Effects of Vitamins and Micronutrients on Helicobacter pylori Pathogenicity, Survival, and Eradication: A Crosstalk between Micronutrients and Immune System
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H. pylori increases risk of certain kind of stomach, or gastric, cancer by 8 X

WebMED
See also Gastric Cancer, Vitamin D, VDR, UV - many studies

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Can probablhy fight Helicobacter pylori better with Gut-Friendly Vitamin D

Gut-friendly forms include topical and mucosal which totally by-pass the stomach

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16,700 resuts from search of "Helicobacter pylori " "vitamin d" as of Dec 2022

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• The Association between Serum Vitamin D Levels and Helicobacter pylori Presence and Eradication 0 Jan 2021 https://doi.org/10.3390/nu13010278 FREE PDF
• Response of Helicobacter Pylori Eradication Treatment in Patients With Normal and Below-Normal Serum Vitamin D Levels April 2021 10.7759/cureus.14777 FREE PDF
• Helicobacter Pylori Interacts with Serum Vitamin D to Influence Hypertension - 2021 https://doi.org/10.2174/1874609813666200925104248
• Influence of adding vitamin D3 to standard clarithromycin-based triple therapy on the eradication rates of Helicobacter pylori infection 0 Sept 2021 https://doi.org/10.1016/j.ajg.2021.08.002
• Association of hypertension with helicobacter pylori: A systematic review and meta‑analysis May, 2022 https://doi.org/10.1371/journal.pone.0268686  PDF

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