Hypertension 2X more likely if poor CYP24A1 vitamin D gene (China) – Jan 2020

The Impact of CYP24A1 Polymorphisms on Hypertension Susceptibility.

Kidney Blood Press Res. 2020 Jan 9:1-10. doi: 10.1159/000503925.

VitaminDWiki

A poor CYP24A1 gene destroys fully activated Vitamin D
A Vitamin D blood test measures semi-activated Vitamin D

CYP24A1 gene and Vitamin D - many studies

Items in both categories Hypertension and Genetics are listed here:

Items in both categories Hypertension and Vitamin D Receptor are listed here:

Genetics category listing contains the following

343 articles in the Genetics category

see also

Vitamin D blood test misses a lot
in Visio for 2023

  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)   Commercially available 2019
    • However, test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
        especially if it is one of 51+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
    3) DNA and VDR tests - 120 to 200 dollars $100 to $250
    4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
       Genes are good, have enough Magnesium, etc.
    5) Back Pain
       probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
      • The founder of VitaminDWiki took action with clues #3&5

Cancers might alter CYP24A1 gene

 Download the PDF from VitaminDWiki
Image
Bao Q1, Wang D1, Zhang Y1, Bao L1, Jia H2.
1 Gerontological Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
2 Gerontological Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China, jiahaiyu0228@163.com.

BACKGROUND:
Hypertension is one of the leading causes of human death and disability. CYP24A1 regulates vitamin D activity and is closely linked to hypertension. However, the relationship between CYP24A1polymorphisms and hypertension risk remains unclear.

METHODS:
This case-control study included 503 hypertensive patients and 498 healthy controls from the Chinese Han population. The genotypes of CYP24A1 polymorphisms were detected using the Agena MassARRAY method. The association between genetic variations of CYP24A1and hypertension risk was evaluated with odds ratios (OR) and 95% confidence intervals (CI) in genetic models.

RESULTS:
We found that rs56229249 of CYP24A1significantly decreased the hypertension risk in homozygote (OR 0.51, 95% CI 0.29-0.91, p = 0.022) and recessive models (OR 0.51, 95% CI 0.29-0.91, p = 0.023). Further stratification analyses indicated that hypertension risk is related to age and sex, rs2762934 polymorphism increases hypertension risk among younger subjects (<61 years), and rs1977297 influences the risk of hypertension among older subjects (≥61 years). In addition, rs2762940 is related to hypertension risk in men, and rs56229249 is a protective factor against hypertension in women.

CONCLUSIONS:
Our study suggests that genetic variations of the CYP24A1gene were significantly associated with susceptibility to hypertension in the Chinese population.

3828 visitors, last modified 15 Jan, 2020,
Printer Friendly Follow this page for updates