Physical activity, dietary calcium to magnesium intake, and mortality in the National Health and Examination Survey 1999–2006 cohort
International Journal of Cancer https://doi.org/10.1002/ijc.32634
Elizabeth A. Hibler PhD, MPH Xiangzhu Zhu MD, MPH Martha J. Shrubsole PhD Lifang Hou MD, PhD Qi Dai MD, PhD
Death rates for 20,000 people, 2,600 deaths (smaller is better)
| Cancer Deaths | CVD Deaths | |
| High Exercise and < RDA Magnesium | 0.6 | 0.38 |
| High Exercise and RDA level of Magnesium | 0.47 | 0.40 |
- Death after Breast Cancer 2 times less likely if take lots of Magnesium – Dec 2015
- Colon cancer 25 percent less likely if consume Calcium, Magnesium, Zinc, etc.– Nov 2018
- Pancreatic Cancer risk increased 24 percent for every 100 mg less of Magnesium intake – Dec 2015
- Muscle pain (Low Magnesium) plus Low Vitamin D associated with 10X more Cancer, etc (San Francisco) – Aug 2017
- Breast cancer associated with high Calcium AND low vitamin D - April 2015
- Unhealthy Calcium to Magnesium ratio
Note: Increasing Magnesium increases both Vitamin D in blood and in tissues
click on chart for details
Magnesium is vital to Vitamin D in 4 places (maybe 8) – March 2018
Magnesium and Vitamin D contains the following summary
- Overview Magnesium and vitamin D
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- The ONE Supplement All Longevity Experts Are Taking (Magnesium) - video and transcript Dec 2023
- Magnesium deficiency – causes and symptoms – May 2016
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- Vitamins and Metals needed by the Immune System – Jan 2020
- Magnesium: intake decreased, difficult to measure in body – Sept 2018
- Magnesium deficiency estimated by just 6 Yes No questions - Dec 2019
- Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
- Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017
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- How to get lots of Magnesium – especially needed for Coimbra MS and Autoimmune Protocol
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Magnesium and Vitamin D
- Intracellular Magnesium and Vitamin D - a few studies
- Vitamin D and Magnesium need each other - many studies
- Why Vitamin D is Useless without This Critical Nutrient (Magnesium) - Jan 2019
- 500 mg of Magnesium for 8 weeks increased Vitamin D by 4 ng – July 2020
- Magnesium and Vitamin D - pre-colon cancer – RCT Dec 2018
- Magnesium is vital to Vitamin D in 4 places (maybe 8) – March 2018
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- Vitamin D Cofactors in a nutshell
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12+ VitaminDWiki Magnesium pages have MANY STUDIES in the title
The list is automatically updated
Overview Magnesium and vitamin D Has a venn diagram of relationship of Mg and Vit D
| Magnesium | not Magnesium | |
| Vitamin D | Magnesium or Vitamin D Aging, Amyotrophic Lateral Sclerosis, Alzheimer's Disease; Asthma, Attention Deficit Disorder, Autism, Cancer, Cerebrovascular, Chronic Fatigue, Diabetes, Hearing Loss, Heart Disease, Heart Attack, Atherosclerosis, Cardiovascular Disease, HIV, AIDS; Hypertension; Kidney Stones, Migraine Headache, Multiple Sclerosis, Obesity, Osteoporosis, Peripheral vascular disease; Pregnancy-related problems, Rheumatoid Arthritis, Sports-related problems, | Vitamin D only Acne, Allergy, Autoimmune, Bone, Breathing, Celiac, Cognition, Colds and Flu, Cystic Fibrosis, Dental, Fertility, hyperparathyroid, Immunity, Kidney, Liver, Lupus, Osteoarthritis, Pain - chronic, Parkinson, Psoriasis, Rickets, Strokes, Sarcoidosis, Thyroid, Parathyroid, Tuberculosis, Vision, Hair, Skin, Sports |
| Not Vitamin D | Magnesium only Aggressive Behavior, Alcoholism, Arrhythmia, Cerebral Palsy, Chemical Sensitivity, Cluster Headaches; Cocaine-related Stroke; Constipation, Cramps, Fluoride Toxicity, Head Injuries, Central Nervous System Injuries, Magnesium Deficiency; Menopause, Mitral Valve Prolapse, Nystagmus, Psychiatric Disorders; Repetitive Strain Injury, Sickle Cell Disease, SIDS, Stress, Stuttering, Tetanus; Tinnitus, Sound Sensitivity; TMJ; Toxic Shock; Violence | Neither ALL OTHER DISEASES |
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Calcium and magnesium affect muscle mass and function. Magnesium and calcium are also important for optimal vitamin D status. Vitamin D status modifies the associations between physical activity and risk of incident cardiovascular disease (CVD) and CVD mortality. However, no study examined whether levels of magnesium and calcium and the ratio of dietary calcium to magnesium (Ca:Mg) intake modify the relationship between physical activity and mortality. We included 20,295 National Health and Nutrition Examination Survey participants (1999–2006) aged >20 years with complete dietary, physical activity, and mortality data (2,663 deaths). We assessed physical activity based on public health guidelines and sex‐specific tertiles of MET‐minutes/week. We used Cox proportional hazards models adjusted for potential confounding factors and stratified by the intakes of magnesium, calcium, Ca:Mg ratio.
We found higher physical activity was significantly associated with reduced risk of total mortality and cause‐specific mortality, regardless of Ca:Mg ratio, magnesium or calcium intake. In contrast, both moderate and high physical activity were significantly associated with substantially reduced risks of mortality due to cancer when magnesium intake was above the RDA level. We also found higher physical activity was significantly associated with a reduced risk of mortality due to cancer only when Ca:Mg ratios were between 1.7–2.6, although the interaction was not significant. Overall, dietary magnesium and, potentially, the Ca:Mg ratio modify the relationship between physical activity and cause‐specific mortality. Further study is important to understand the modifying effects of the balance between calcium and magnesium intake on physical activity for chronic disease prevention.
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