Associations between calcium and vitamin D supplement use as well as their serum concentrations and subclinical cardiovascular disease phenotypes.
Atherosclerosis. 2015 Jun 19;241(2):743-751. doi: 10.1016/j.atherosclerosis.2015.06.032
Thiele I1, Linseisen J2, Meisinger C3, Schwab S4, Huth C5, Peters A6, Perz S7, Meitinger T8, Kronenberg F9, Lamina C10, Thiery J11, Koenig W12, Rathmann W13, Kääb S14, Then C15, Seissler J16, Thorand B17.
It is not a surprise that increased Calcium is associated with heart problems
Pages in VitaminDWiki listed in BOTH the categories Calcium and Cardiovascular
- Calcium Supplementation is OK provided you also take Vitamin K – Feb 2019
- Less than 900 IU of Vitamin D and Calcium do not cause cardiovascular problems – Dec 2016
- 800 IU of vitamin D is not enough to help Cardiovascular Disease (found again) – Oct 2016
- Calcium supplementation associated with 3.9X increase risk of atrial fibrillation – June 2015
- Adding Calcium does NOT cause cardiovascular problems (reverses their meta-analysis) – Dec 2014
- Increased Vitamin K2 reduces the problems of excess Calcium – Nov 2013
- More than 400 mg of Calcium supplements caused cardiovascular deaths in men - Feb 2013
- Stiff arteries in seniors associated with low vitamin D levels – July 2012
- Aortic Calcification 85 percent more likely if vitamin D level lower than 29 ng – June 2012
- More than 800 mg of Calcium increases Cardiovascular events by 85 percent– Nov 2011
- Is excess calcium harmful to health - 2010
- Review of Calcium – Vitamin D - Cardiovascular Disease – June 2011
- Calcium without vitamin D increased heart risk by 30 percent - Jan 2011
- Heart attacks increased by 30% in those taking 500 mg of Calcium without vitamin D – July 2010
Pages listed in BOTH the categories Magnesium and Cardiovascular
- More Magnesium needed to decrease diabetes, cardio, HT (body weight has increased) - March 2021
- Nitric oxide increased by UVA, Vitamin D, Magnesium, etc,
- Atrial Fibrillation in VitaminDWiki - many studies
- Signs of low Magnesium (heart problems in this case) – Jan 2018
- Ablation does not reduce atrial fibrillation (CABANA study) but Magnesium does – June 2018
- Cardiometaboic problems decreased with increased Vitamin D, unless low Magnesium – Aug 2017
- Heart problems in obese increase if deficient in BOTH Vitamin D and Magnesium – Aug 2017
- Health problems prevented by eating nuts (perhaps due to Magnesium and or Omega-3) – meta-analysis Dec 2016
- Cardiovascular calcification prevented by Omega-3, Magnesium, Vitamin K, and Vitamin D – April 2015
- More vitamin D makes for better health – dissertation based on Rotterdam studies – Oct 2015
- Atrial Fibrillation - remineralize your heart - Aug 2015
- Magnesium Suppresses Formation of Clogged Arteries - May 2014
- Off Topic: EDTA similar reduction in heart attack as Vitamin C, aspirin and Mg – RCT March 2013
- Death from Coronary Heart Disease related to low Magnesium intake – March 2013
- Magnesium prevents cardiovascular events – Meta-analysis March 2013
- Hypothesis: Decreasing Magnesium and increasing CaMg ratio are increasing health problems – 2012 - 2013
- Heart problems such as Afib related to little Magnesium, Omega-3, Vitamin D getting to tissues
25 citations of the study as of April 2023
Note: The increased Afib is probably due to the high ratio of Ca to Mg
Supplementation of calcium (Ca) and vitamin D for the prevention of osteoporosis is frequently found in Western countries. Recent re-analyses of clinical trials observed a higher risk of myocardial infarction and stroke in subjects taking Ca (+vitamin D) supplements, although the underlying mechanisms are not clear.
Thus, we analyzed the associations between Ca and vitamin D supplementation as well as serum concentrations of Ca and 25-hydroxyvitamin D (25(OH)D) and subclinical cardiovascular disease (CVD) phenotypes, namely intima-media thickness, ankle-brachial-index (ABI), intermittent claudication, and atrial fibrillation (AF).
Data of 1601 participants aged 50-81 years of the population-based cross-sectional Cooperative Health Research in the Region of Augsburg (KORA) F4 study in Germany were analyzed. Logistic and linear regression models were used to estimate odds ratios (OR) (95% confidence intervals (CI)) and β-estimates (p-values), respectively.
Regular Ca supplementation showed a significant positive association with the presence of AF after multivariable adjustment (OR = 3.89; 95% CI 1.28-11.81). Higher serum 25(OH)D concentrations were independently associated with a lower prevalence of asymptomatic peripheral arterial disease as assessed by ABI measurements (β = 0.007; p = 0.01). No other significant associations between supplementation or serum concentrations of Ca or vitamin D and CVD phenotypes were identified.
Although based on few cases the finding of a significant higher prevalence of AF in Ca supplement users hints at one possible mechanism that may contribute to an increased risk of myocardial infarction and stroke. The observed association between serum 25(OH)D and ABI supports results from other studies.
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