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Calcium supplementation associated with 3.9X increase risk of atrial fibrillation – June 2015

Associations between calcium and vitamin D supplement use as well as their serum concentrations and subclinical cardiovascular disease phenotypes.

Atherosclerosis. 2015 Jun 19;241(2):743-751. doi: 10.1016/j.atherosclerosis.2015.06.032
Thiele I1, Linseisen J2, Meisinger C3, Schwab S4, Huth C5, Peters A6, Perz S7, Meitinger T8, Kronenberg F9, Lamina C10, Thiery J11, Koenig W12, Rathmann W13, Kääb S14, Then C15, Seissler J16, Thorand B17.


It is not a surprise that increased Calcium is associated with heart problems
Pages in VitaminDWiki listed in BOTH the categories Calcium and Cardiovascular

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25 citations of the study as of April 2023
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Note: The increased Afib is probably due to the high ratio of Ca to Mg

Supplementation of calcium (Ca) and vitamin D for the prevention of osteoporosis is frequently found in Western countries. Recent re-analyses of clinical trials observed a higher risk of myocardial infarction and stroke in subjects taking Ca (+vitamin D) supplements, although the underlying mechanisms are not clear.

Thus, we analyzed the associations between Ca and vitamin D supplementation as well as serum concentrations of Ca and 25-hydroxyvitamin D (25(OH)D) and subclinical cardiovascular disease (CVD) phenotypes, namely intima-media thickness, ankle-brachial-index (ABI), intermittent claudication, and atrial fibrillation (AF).

Data of 1601 participants aged 50-81 years of the population-based cross-sectional Cooperative Health Research in the Region of Augsburg (KORA) F4 study in Germany were analyzed. Logistic and linear regression models were used to estimate odds ratios (OR) (95% confidence intervals (CI)) and β-estimates (p-values), respectively.

Regular Ca supplementation showed a significant positive association with the presence of AF after multivariable adjustment (OR = 3.89; 95% CI 1.28-11.81). Higher serum 25(OH)D concentrations were independently associated with a lower prevalence of asymptomatic peripheral arterial disease as assessed by ABI measurements (β = 0.007; p = 0.01). No other significant associations between supplementation or serum concentrations of Ca or vitamin D and CVD phenotypes were identified.

Although based on few cases the finding of a significant higher prevalence of AF in Ca supplement users hints at one possible mechanism that may contribute to an increased risk of myocardial infarction and stroke. The observed association between serum 25(OH)D and ABI supports results from other studies.
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ID Name Comment Uploaded Size Downloads
19454 Ca Cardio.pdf admin 12 Apr, 2023 1.26 Mb 57