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Breast and Liver Cancers statistically associated with low vitamin D (Japan) – March 2018

Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific cancers in Japanese population: large case-cohort study within Japan Public Health Center-based Prospective Study cohort

BMJ 2018; 360 doi: https://doi.org/10.1136/bmj.k671 (Published 07 March 2018)


Liver Cancer and Vitamin D

Breast Cancer and Vitamin D

Overview Breast Cancer and Vitamin D contains the following summary and sections

Dark Skinned women have worse problems with breast cancer

Breast cancer worse for black women – Sept 2011
Vitamin D receptor in breasts and breast cancer vary with race – March 2013
Genes may account for some of AA Breast Cancer – April 2012
Breast cancer more deadly for blacks than whites
Hypothesis: Blacks get more cancer than whites due to lower levels of vitamin D – June 2012
Overview Dark Skin and Vitamin D
Differences in black and non-black mortality and vitamin D – Oct 2012

More about Vitamin D

Many people around the world are vitamin D deficient

Many reasons why vitamin D deficiency has become epidemic

Many ways to increase your vitamin D levels

Overview Vitamin D Dose-Response
Many hints that vitamin D megadoses cure some diseases
Dose response equations for Vitamin D
Overview Loading of vitamin D
Overview Toxicity of vitamin D hard to overdose
How you might double your response to vitamin D

When taking more Vitamin D you must also balance micronutrients - such as Magnesium and Calcium

Hypothesis: increased breast cancer if not enough magnesium – Sept 2010
Hypothesis – anticancer benefits from synergy of omega-3 and vitamin D – May 2011
Hypothesis: Premenopausal Iron deficiency causes increased recurrence of breast cancer – 2008

Vitamin D comes in many forms: vegan, liquid, poor digestion . .

Vitamin D3 for Vegans
Quantum dots should deliver active vitamin D directly to inflammatory breast cancer tumors – Feb 2013
Active form of vitamin D appears to help prevent and treat some cancers – Feb 2011
Forms of vitamin D: not have to take pills, poor digestion, etc.

You can also get vitamin D from the sun and UV bulbs

The sun appears better at reducing incidence of some cancers than vitamin D – Dec 2012
Less UV: 2X more breast cancer – June 2011
More Cancer, less Solar Radiation - 1941
Need lots of UV AND vitamin D to reduce risk of breast cancer – Jan 2011
Vitamin D, Sunlight and Cancer Connection – Holick Jan 2013
Solar UVB reduces Cancer Risk – Grant, Jan 2013
More UVB is associated with less cancer – study of 450,000 people – April 2012
Photodynamic therapy for Cancer might be helped by vitamin D – July 2012
A review of the evidence regarding the solar ultraviolet-B-vitamin D-cancer hypothesis - Oct 2012
How you can get more UV without getting too hot in the sun
How you can get more UV without exposing too much skin to the sun

Reasons for taking even more vitamin D

Obesity, trauma, major health problem
Not get much D from the sun: Dark Skin, Shut-in, Far from equator

If Breast Cancer runs in your family

Vitamin D level can be high, but little benefit: due to kidney, genes, low Magnesium etc.
County with 20 pcnt higher breast cancer rate has 2X more modified vitamin D receptor – July 2012
Breast Cancer incidence change by 40 percent with vitamin D receptor genes – Oct 2012
Genes breast cancer and vitamin D receptor - Sept 2010
CYP24A1 gene in cancer cells may actually deactivate vitamin D – Oct 2012
Genes such as CYP27B1, CYP24A1 and Vitamin D – JAMA Nov 2012

How vitamin D prevents and treats other cancers

Overview Cancer and vitamin D
Metastatic Cancer is maybe reduced by vitamin D - 5 articles
How Vitamin D prevents many cancers (c-MYC) – Nov 2012
Vitamin D and cancer: a view based of all models – April 2012
Advanced stage cancer 3X more likely if low level of vitamin D – March 2012
Possible ways that vitamin D does its magic

Breast cancer experience of Carole Baggerly - who survived and created GrassrootsHealth

From Oct 2015 newsletter
In 2005, when I had breast cancer, I learned many things. I truly came to understand that one of the biggest things one faces with a serious disease is a challenge to one's values. At the beginning, when diagnosed with a stage 3 tumor, 2.5 inches in diameter (yes, 2.5 inches), the oncologist said, "of course, you'll do surgery, chemo and radiation."
Value test #2: During the 2nd round of chemo treatment, I had Paclitaxel which can create a very painful neuropathy, in my case, in the legs and feet. This was extremely debilitating and painful to me. I finally felt "NO! I will not allow this VIOLENCE against my body to continue." The value was non-violence, a very strongly held one. Little did I realize it applied to treatment of my own body.
Value test #3: During radiation, there is definitely scattering of the beams and even though they are more targeted than in the past, there is significant impact on the thyroid (mine is gone), the heart and lung. During one session, I was bleeding from my chest (due to the burning) and again, told the radiologist I would do no more treatments. He was more reasonable, but still wanted me to continue. I did not.
These values are what led to the establishment of GrassrootsHealth - and, are what leads us to ask you to help us change the game, to change the questions from drug related solutions to the things we can do with appropriate nutrition (a big player, of course, is vitamin D) and actions.

See also web - other than Vitamin D

Mammography reduces BC death rate by 1 in 1000, but 10 in 1000 get treatment for no reason

Short url = http://is.gd/vitdbc

Cancer and Vitamin D

Cancer category starts with the following

Here are all 170 of the articles

See also web

  • Phrases associated with cancer NYT Jan 2015
    “failed tamoxifen”,“platinum resistant” or “refractory” patient, “relapsed” scans which are “clean,” “positive” or “advancing” spells trouble
    nodes have been “harvested”; a tumor is “indolent, “minimal or acceptable side effects,” scanxiety,
    Nothing about vitamin D
  • How cancer cells form tumors by reaching out with ‘cables’ and grabbing cells Jan 2016 (nothing about vitamin D)
    "Surprisingly, as little as five percent of cancerous cells are needed to form the tumors, a ratio previously unknown."
    “It’s that these cells go out and actively recruit. It’s complicated stuff, and it’s not passive. No one had a clue that there were specialized cells in this process, and that it’s a small number that pulls all the rest in.”
    Images from the movie


 Download the PDF from VitaminDWiki

Objective To evaluate the association between pre-diagnostic circulating vitamin D concentration and the subsequent risk of overall and site specific cancer in a large cohort study.

Design Nested case-cohort study within the Japan Public Health Center-based Prospective Study cohort.

Setting Nine public health centre areas across Japan.

Participants 3301 incident cases of cancer and 4044 randomly selected subcohort participants.

Exposure Plasma concentration of 25-hydroxyvitamin D measured by enzyme immunoassay. Participants were divided into quarters based on the sex and season specific distribution of 25-hydroxyvitamin D among subcohorts. Weighted Cox proportional hazard models were used to calculate the multivariable adjusted hazard ratios for overall and site specific cancer across categories of 25-hydroxyvitamin D concentration, with the lowest quarter as the reference.

Main outcome measure Incidence of overall or site specific cancer.

Results Plasma 25-hydroxyvitamin D concentration was inversely associated with the risk of total cancer, with multivariable adjusted hazard ratios for the second to fourth quarters compared with the lowest quarter of 0.81 (95% confidence interval 0.70 to 0.94), 0.75 (0.65 to 0.87), and 0.78 (0.67 to 0.91), respectively (P for trend=0.001). Among the findings for cancers at specific sites, an inverse association was found for liver cancer, with corresponding hazard ratios of 0.70 (0.44 to 1.13), 0.65 (0.40 to 1.06), and 0.45 (0.26 to 0.79) (P for trend=0.006). A sensitivity analysis showed that alternately removing cases of cancer at one specific site from total cancer cases did not substantially change the overall hazard ratios.

Conclusions In this large prospective study, higher vitamin D concentration was associated with lower risk of total cancer. These findings support the hypothesis that vitamin D has protective effects against cancers at many sites.

Created by admin. Last Modification: Thursday March 8, 2018 19:11:35 UTC by admin. (Version 5)
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9468 Cancer Japan.jpg admin 08 Mar, 2018 18:53 209.03 Kb 30
9467 Cancer Japan.pdf PDF 2018 admin 08 Mar, 2018 18:53 361.88 Kb 17
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