Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific cancers in Japanese population: large case-cohort study within Japan Public Health Center-based Prospective Study cohort
BMJ 2018; 360 doi: https://doi.org/10.1136/bmj.k671 (Published 07 March 2018)
Liver Cancer and Vitamin D
- Liver, Liver Cancer, and Vitamin D – Feb 2018
- Liver cancer incidence probably reduced by Vitamin D and Vitamin K – July 2017
- Liver cancer half as likely if high level of vitamin D – Feb 2014
Breast Cancer and Vitamin D
- Vitamin D after breast cancer diagnosis - May 2012
- Breast Cancer prevented by Vitamin D (most studies concur) – Dec 2017
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
- Breast Cancer chemotherapy 2.7 X more likely to be successful if not vitamin D deficient – Dec 2017
- Breast Cancer trial using 50,000 IU Vitamin D weekly cancelled (no funding)
Overview Breast Cancer and Vitamin D contains the following summary and sections
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25 Meta-analyses of Vitamin D and Breast Cancer
example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D.- Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
wonder just how much more proof is needed- Breast Cancer 4X more likely if have poor genes
- Cancer - Breast category listing has
259 items along with related searches - Breast Cancer treatment – Vitamin D was the most-popular supplement – Jan 2023
- Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020
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Cancer and Vitamin D
- Evidence that Vitamin D prevents Cancer – Grant Feb 2018
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- Dogs with Cancer have low vitamin D, same as humans – Sept 2017
- Cancer risk in older women reduced 32 percent by 2,000 IU of Vitamin D plus Calcium – 4 year RCT Oct 2016
- If you were born after 1960 your risk of getting cancer is 1 in 2 if you do not get a lot of vitamin D
Cancer category starts with the following
- Cancer
293 items Overview Cancer and vitamin D - Cancer and Vitamin D - many studies
- After Cancer Diagnosis
113 items - Bladder Cancer
28 items - Breast Cancer
259 items Overview Breast Cancer and Vitamin D - Colon Cancer
144 items Overview Cancer-Colon and vitamin D - Leukemia
19 items - Liver Cancer
17 items - Lung Cancer
55 items Overview Lung cancer and vitamin D - Lymphoma Cancer
26 items - Other Cancer
66 items - Ovarian Cancer
26 items - Pancreatic Cancer
57 items - Prostate Cancer
103 items Overview Prostate Cancer and Vitamin D - Skin Cancer
121 items Overview Suntan, melanoma and vitamin D - Childhood Cancers - Vitamin D can help - many studies
- Easiest way to treat cancer – take Vitamin D – Nov 2022
- 13 Cancers are helped by Vitamin D – Biobank July 2023
- 2X increase of 14 cancers in non-seniors in 20 years (low vitamin D) – Sept 2022
- Vitamin D prevents and treats cancer in many ways – May 2021
- Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
- 8 ways that Cancer might be prevented by Vitamin D - June 2019
- Cancer stem cells and Vitamin D - many studies
- Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
- Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
- Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
- Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
- Melanoma 25 X more likely if low vitamin D – Feb 2018
- Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018
Cancers get less Vitamin D when there is a poor Vitamin D Receptor- Vitamin D Receptor pages in VitaminDWiki with CANCER in title 86 as of July 2023
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Vitamin D Receptor (Cancers OR Viruses) - many studies
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer (general) and VDR
23 articles - Breast Cancer and VDR
24 articles - Colon Cancer and VDR
13 articles - Prostate Cancer and VDR
7 articles - Skin Cancer and VDR
10 articles - Note some Health problems, such as some Cancers, protect themselves
by actively reducing Receptor activation
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Objective To evaluate the association between pre-diagnostic circulating vitamin D concentration and the subsequent risk of overall and site specific cancer in a large cohort study.
Design Nested case-cohort study within the Japan Public Health Center-based Prospective Study cohort.
Setting Nine public health centre areas across Japan.
Participants 3301 incident cases of cancer and 4044 randomly selected subcohort participants.
Exposure Plasma concentration of 25-hydroxyvitamin D measured by enzyme immunoassay. Participants were divided into quarters based on the sex and season specific distribution of 25-hydroxyvitamin D among subcohorts. Weighted Cox proportional hazard models were used to calculate the multivariable adjusted hazard ratios for overall and site specific cancer across categories of 25-hydroxyvitamin D concentration, with the lowest quarter as the reference.
Main outcome measure Incidence of overall or site specific cancer.
Results Plasma 25-hydroxyvitamin D concentration was inversely associated with the risk of total cancer, with multivariable adjusted hazard ratios for the second to fourth quarters compared with the lowest quarter of 0.81 (95% confidence interval 0.70 to 0.94), 0.75 (0.65 to 0.87), and 0.78 (0.67 to 0.91), respectively (P for trend=0.001). Among the findings for cancers at specific sites, an inverse association was found for liver cancer, with corresponding hazard ratios of 0.70 (0.44 to 1.13), 0.65 (0.40 to 1.06), and 0.45 (0.26 to 0.79) (P for trend=0.006). A sensitivity analysis showed that alternately removing cases of cancer at one specific site from total cancer cases did not substantially change the overall hazard ratios.
Conclusions In this large prospective study, higher vitamin D concentration was associated with lower risk of total cancer. These findings support the hypothesis that vitamin D has protective effects against cancers at many sites.
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- Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer