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Dogs with Cancer have low vitamin D, same as humans – Sept 2017

Influence of Various Factors on Circulating 25(OH) Vitamin D Concentrations in Dogs with Cancer and Healthy Dogs.

J Vet Intern Med. 2017 Sep 23. doi: 10.1111/jvim.14834. [Epub ahead of print]
Weidner N1, Woods JP1, Conlon P2, Meckling KA3, Atkinson JL4, Bayle J5, Makowski AJ6, Horst RL6, Verbrugghe A1.

VitaminDWiki Summary
Diagnosed with Cancer in lifetime25%38%
Other diseases also associated with low DYesYes
Diseases associated with CYP24A1 gene YesYes
Decreased Vitamin D in food/supplements associated with Cancer YesYes
Vitamin D reduces pain of arthritis, etc.YesYes

Additional studies in VitaminDWiki

Cancer category (for humans) starts with the following

Cancers get less Vitamin D when there is a poor Vitamin D Receptor

 Download the PDF from VitaminDWiki


Low blood 25-hydroxyvitamin D (25(OH)D) concentrations have been associated with cancer in dogs. Little research has examined what other factors may affect 25(OH)D concentrations.

(1) To determine whether the presence of cancer (lymphoma, osteosarcoma, or mast cell tumor [MCT]) in dogs is associated with plasma 25(OH)D concentrations and (2) identify other factors related to plasma 25(OH)D concentrations in dogs.

Dogs newly diagnosed with osteosarcoma (n = 21), lymphoma (n = 27), and MCT (n = 21) presented to a tertiary referral oncology center, and healthy, client-owned dogs (n = 23).

An observational study design was used. Dietary vitamin D intake, sex, age, body condition score (BCS), muscle condition score (MCS), and plasma concentrations of 25(OH)D, 24,25-dihydroxyvitamin D (24,25(OH)2 D) (a marker of CYP24A1 activity), as well as ionized calcium (ICa), parathyroid hormone, and parathyroid hormone-related protein concentrations were measured. An analysis of covariance was used to model plasma 25(OH)D concentrations.

Cancer type (P = 0.004), plasma 24,25(OH)2 D concentrations (P < 0.001), and plasma ICa concentrations (P = 0.047) had significant effects on plasma 25(OH)D concentrations. Effects of age, sex, body weight, BCS, MCS, and plasma PTH concentrations were not identified. A significant interaction between ICa and cancer was found (P = 0.005). Plasma 25(OH)D concentrations increased as ICa concentrations increased in dogs with cancer, whereas plasma 25(OH)D concentrations decreased as ICa concentrations increased in healthy dogs.

Results support a relationship between cancer and altered vitamin D metabolism in dogs, mediated by plasma ICa concentrations. The CYP24A1 activity and plasma ICa should be measured in studies examining plasma 25(OH)D concentrations in dogs.

PMID: 28941306 DOI: 10.1111/jvim.14834

Created by admin. Last Modification: Thursday March 29, 2018 00:57:08 GMT-0000 by admin. (Version 7)

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8471 Canine Cancer.jpg admin 24 Sep, 2017 14:23 58.99 Kb 441
8470 Canine Cancer.pdf PDF 2017 admin 24 Sep, 2017 14:23 365.71 Kb 403
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