Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults
Journal of Hypertension: March 22, 2018. doi: 10.1097/HJH.0000000000001728
Filipovic, Mark, G.a,b; Aeschbacher, Stefaniec; Reiner, Martin, F.a,b; Stivala, Simonab; Gobbato, Sarab; Bonetti, Nicoleb; Risch, Martind,e; Risch, Lorenzd,f,g; Camici, Giovanni, G.b; Luescher, Thomas, F.h; von Schacky, Clemensi; Conen, Davidc,j; Beer, Juerg, H.a,b
Hypertension category listing contains the following
see also
Overview Overview Hypertension and Vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 22 health problems related to vitamin D have doubled in a decade
Some interesting Hypertension studies
- Hypertension risk decreased 10X by increasing vitamin D levels to more than 40 ng – Nov 2017
- Hypertension risk reduced 4X if adequate level of Vitamin D – July 2024
- COVID-19 deaths 4 to 7 X more likely if Diabetic, Hypertensive, or CVD - meta-analysis March 2020
- Magnesium reduces hypertension - FDA allows claim - Jan 2022
- Drug-resistant hypertension 3.5 X more likely if low vitamin D – March 2020
- High Blood Pressure reduced by Vitamin D supplementation in seniors and obese – meta-analysis May 2019
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- Hypertension is associated with low vitamin D in some groups – meta-analysis April 2015
- Off Topic – Hypertension in 42 percent of adults (new definition: 130 mm Hg) – Feb 2018
- Men aged 40-59 59%, age >60 75%: National Health and Nutrition Examination Survey, 2017–2018
Hypertension and Omega-3
- Blood pressure reduced if take more than 4.5 grams of Omega-3 daily– umbrella meta-analysis Aug 2022
- Blood pressure 4 mm lower if Omega-3 index was high – March 2018
- Cardiovascular problems reduced by low dose aspirin and perhaps Omega-3 (also Vit K) – Sept 2017
- Hypertension reduced by Omega-3, especially if previously untreated – meta-analysis July 2014
Hypertension and Magnesium (which reduces HT than Omega-3)
- Magnesium raised Vitamin D, lowered blood pressure and Ca to Mg ratio – RCT Sept 2024
- Magnesium Depletion Score predicts increased risk of various health problems
- Magnesium reduces hypertension - FDA allows claim - Jan 2022
- Hypertension reduced by Magnesium plus 3,000 IU of vitamin D for 12 weeks – RCT July 2022
- More Magnesium needed to decrease diabetes, cardio, HT (body weight has increased) - March 2021
- Hypertension treatment needs at least 600 mg of Magnesium (49 trials) – Jan 2021
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- Reduce blood pressure by 9 mm with triple hypertensive drug or 19 mm with Magnesium – April 2018
- Hypertension nonconventional therapies: Magnesium, melatonin, Vitamin C, etc. – Jan 2018
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Prehypertension risk is increased by 78% if low Magnesium – Aug 2015
- Preeclampsia inversely proportional to serum Magnesium – Oct 2014
- Hypertension 1.5X more likely if low level of Magnesium - Oct 2014
Background: Omega-3 fatty acids (n − 3 FA) may have blood pressure (BP)-lowering effects in untreated hypertensive and elderly patients. The effect of n − 3 FA on BP in young, healthy adults remains unknown. The Omega-3 Index reliably reflects an individuals’ omega-3 status. We hypothesized that the Omega-3 Index is inversely associated with BP levels in young healthy adults.
Methods: The current study (n = 2036) is a cross-sectional study investigating the baseline characteristics of a cohort, which includes healthy adults, age 25–41 years. Individuals with cardiovascular disease, known diabetes or a BMI higher than 35 kg/m2 were excluded. The Omega-3 Index was determined in whole blood using gas chromatography. Association with office and 24-h BP was assessed using multivariable linear regression models adjusted for potential confounders.
Results: Median Omega-3 Index was 4.58% (interquartile range 4.08; 5.25). Compared with individuals in the lowest Omega-3 Index quartile, individuals in the highest had a SBP and DBP that was 4 and 2 mmHg lower, respectively (P < 0.01). A significant linear inverse relationship of the Omega-3 Index with 24-h and office BP was observed. Per 1-U increase in log-transformed Omega-3 Index the lowering in BP (given as multivariable adjusted β coefficients; 95% confidence interval) was −2.67 mmHg (−4.83; −0.51; P = 0.02) and −2.30 mmHg (−3.92; −0.68; P = 0.005) for 24-h SBP and DBP, respectively.
Conclusion: A higher Omega-3 Index is associated with statistically significant, clinically relevant lower SBP and DBP levels in normotensive young and healthy individuals. Diets rich in n − 3 FA may be a strategy for primary prevention of hypertension.
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