Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults
Journal of Hypertension: March 22, 2018. doi: 10.1097/HJH.0000000000001728
Filipovic, Mark, G.a,b; Aeschbacher, Stefaniec; Reiner, Martin, F.a,b; Stivala, Simonab; Gobbato, Sarab; Bonetti, Nicoleb; Risch, Martind,e; Risch, Lorenzd,f,g; Camici, Giovanni, G.b; Luescher, Thomas, F.h; von Schacky, Clemensi; Conen, Davidc,j; Beer, Juerg, H.a,b
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Background: Omega-3 fatty acids (n − 3 FA) may have blood pressure (BP)-lowering effects in untreated hypertensive and elderly patients. The effect of n − 3 FA on BP in young, healthy adults remains unknown. The Omega-3 Index reliably reflects an individuals’ omega-3 status. We hypothesized that the Omega-3 Index is inversely associated with BP levels in young healthy adults.
Methods: The current study (n = 2036) is a cross-sectional study investigating the baseline characteristics of a cohort, which includes healthy adults, age 25–41 years. Individuals with cardiovascular disease, known diabetes or a BMI higher than 35 kg/m2 were excluded. The Omega-3 Index was determined in whole blood using gas chromatography. Association with office and 24-h BP was assessed using multivariable linear regression models adjusted for potential confounders.
Results: Median Omega-3 Index was 4.58% (interquartile range 4.08; 5.25). Compared with individuals in the lowest Omega-3 Index quartile, individuals in the highest had a SBP and DBP that was 4 and 2 mmHg lower, respectively (P < 0.01). A significant linear inverse relationship of the Omega-3 Index with 24-h and office BP was observed. Per 1-U increase in log-transformed Omega-3 Index the lowering in BP (given as multivariable adjusted β coefficients; 95% confidence interval) was −2.67 mmHg (−4.83; −0.51; P = 0.02) and −2.30 mmHg (−3.92; −0.68; P = 0.005) for 24-h SBP and DBP, respectively.
Conclusion: A higher Omega-3 Index is associated with statistically significant, clinically relevant lower SBP and DBP levels in normotensive young and healthy individuals. Diets rich in n − 3 FA may be a strategy for primary prevention of hypertension.