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Vitamin D does not reduce blood pressure in healthy people (no hypertension, etc) – Meta-analysis Jan 2020

Effect of Vitamin D on Blood Pressure and Hypertension in the General Population: An Update Meta-Analysis of Cohort Studies and Randomized Controlled Trials

Prev Chronic Dis 2020;17:190307. DOI: http://dx.doi.org/10.5888/pcd17.190307 A CDC Journal
Dongdong Zhang, MD1; Cheng Cheng, MD2; Yan Wang, MD1; Hualei Sun, MD1; Songcheng Yu, MD1; Yuan Xue, MD1; Yiming Liu, MD1; Wenjie Li, MD, PhD1; Xing Li, MD1

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  • “…hypertension risk reduced by 7% per 25 nmol/L increment in 25(OH)D levels”
  • … we restricted this meta-analysis to analyses of apparently healthy individuals. We excluded trials that have targeted patients with hypertension, diabetes, cardiovascular disease, or other diseases,…

Background
The effect of vitamin D supplementation on blood pressure has been explored in previous meta-analyses, but whether the association is causal in the general population is still unknown. We evaluated the association comprehensively and quantitatively.

Methods
We searched PubMed and Embase for relevant cohort studies and randomized controlled trials (RCTs). We used a 2-step generalized least-squares method to assess the dose–response association of circulating 25-hydroxyvitamin D (25[OH]D) and hypertension and a fixed-effects model to pool the weighted mean differences (WMDs) and corresponding 95% confidence intervals (95% CIs) of blood pressure across RCTs.

Results
We identified 11 cohort studies and 27 RCTs, with 43,320 and 3,810 participants, respectively. The dose–response relationship between circulating 25(OH)D levels and hypertension risk was approximately L-shaped (Pnonlinearity = .04), suggesting that the risk of hypertension increased substantially below 75 nmol/L as 25(OH)D decreased, but it remained significant over the range of 75–130 nmol/L. However, pooled results of RCTs showed that there was no significant reduction in systolic blood pressure (WMD, −0.00 mm Hg; 95% CI, −0.71 to 0.71) or diastolic blood pressure (WMD, 0.19 mm Hg; 95% CI, −0.29 to 0.67) after vitamin D intervention.

Conclusions
The results of this meta-analysis indicate that supplementation with vitamin D does not lower blood pressure in the general population. RCTs with long-term interventions and a sufficient number of participants who have low levels of vitamin D are needed to validate these findings.

Created by admin. Last Modification: Friday January 10, 2020 11:45:56 GMT-0000 by admin. (Version 15)

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