Toggle Health Problems and D

NAFLD and Vitamin D - many studies

NAFLD ==> decreased semi-activation of vitamin D: should use a form that does not need the liver

Topical Vitamin D
Alternately: use larger doses of Vitamin D

NAFLD increased 1.7X to 12X in recent years in those under 20 - Oct 2023

NAFLD Has Become a Health Emergency Among Children - Mercola
1 hour YouTube video

  • NAFLD also affects up to 9.6% of American children aged 2 to 19, making it as common as asthma. In 15- to 19-year-olds, prevalence is as high as 17.3%. Prevalence among children 0 to 17 has risen 168.3% since 2017, with a particularly precipitous rise starting in 2020"
  • "The dramatic rise in NAFLD in early 2020 may in part be due to the COVID lockdowns, which had the effect of raising childhood obesity rates by 8.3% to 13.4%, depending on the age group"

 Download the Mercola PDF from VitaminDWiki
- - - - - -
Incidence of Nonalcoholic Fatty Liver Disease Rises Quickly in U.S. Military - 2019

NAFLD is treated by Vitamin D, Omega-3, etc. Aug 2023

NAFLD and nutraceuticals: a review of completed phase III and IV clinical trials
Front Med (Lausanne) . 2023 Aug 1;10:1227046. doi: 10.3389/fmed.2023.1227046
Omar E Hegazi 1 2, Samer O Alalalmeh 1 2, Ghala Rashid Humaid Alnuaimi 1 2, Moyad Shahwan 1 2, Ammar Abdulrahman Jairoun 3 4, Nasser M Alorfi 5, Shaker A Majrashi 6, Mustfa Faisal Alkhanani 7, Abdullah Alkhattabi 8, Mansour M Alourfi 8 9, Faris A Alsolami 10, Saeed Alsharif 11, Hatim Alshahrani 12

Background: Nonalcoholic Fatty Liver Disease (NAFLD) has become a significant public health concern, affecting approximately one-fourth of the population. Despite its prevalence, no FDA-approved drug treatments specifically target NAFLD.

Aim: To provide a review of clinical trials investigating the use of herbal remedies and dietary supplements in NAFLD management, utilizing the ClinicalTrials.gov database.

Methods: This review evaluates the current evidence by examining completed phase III and IV clinical trials registered on ClinicalTrials.gov. An exhaustive search was performed on April 17, 2023, using the terms "Nonalcoholic Fatty Liver Disease" and "NAFLD." Two independent reviewers appraised eligible trials based on pre-defined inclusion and exclusion criteria.

Results: An initial search yielded 1,226 clinical trials, with 12 meeting the inclusion criteria after filtration.
The majority of trials focused on

  • Omega-3 fatty acids (20.0%) and
  • vitamin D (26.7%),

followed by caffeine, chlorogenic acid, ginger, phosphatidylcholine, Trigonella Foenum-graecum seed extract, vitamin C, and vitamin E (each 6.7%). Most studies were Phase 3 (75.0%) and used a parallel assignment model (91.7%). Quadruple masking was the most prevalent technique (58.3%), and Iran was the leading country in terms of trial locations (25.0%). These interventions constitute two herbal interventions and nine supplement interventions.

Conclusion: This reveals a diverse range of nutraceuticals, with Omega-3 fatty acids and vitamin D being predominant in the management of NAFLD. The global distribution of trials highlights the widespread interest in these therapeutics. However, more rigorous, large-scale trials are needed to establish safety, efficacy, and optimal dosages.
 Download the PDF from VitaminDWiki

NAFLD helped a bit by a single 300,000 IU Vitamin D dose (needed larger maintenance doses) – RCT March 2023

The effect of high oral loading dose of cholecalciferol in non-alcoholic fatty liver disease patients. A randomized placebo controlled trial
Front Pharmacol . 2023 Mar 14;14:1149967. doi: 10.3389/fphar.2023.1149967. eCollection 2023.
Amal Ahmed Mohamed 1, Ahmed Abdel Halim 2, Sahar Mohamed 2, Seham Mohamed Mahmoud 3, Eman Mohamed Bahgat Eldemiry 4, Rasha Sobh Mohamed 5, Mahmoud Maamoun Shaheen 5, Gina G Naguib 6, Nashwa M Muharram 7, Mona G Khalil 8, Salma Saed 9, Randa Ibrahim 10, Ahmed Salah Seif 11, Noha Kamal 12, Karima Nasraldin 13, Ali Elsaid Abdelrahman 14, Radwa El Borolossy 15

Background and Aim: Non-alcoholic fatty liver (NAFLD) is one of the most common progressive metabolic disorders worldwide. There are increasing scientific interests nowadays for the association between vitamin D status and Non-alcoholic fatty liver. Earlier studies have revealed that vitamin D deficiency is highly prevalent in Non-alcoholic fatty liver patients that contributes to poor outcomes. Hence, the present study aimed to assess the efficacy and safety of oral cholecalciferol on Non-alcoholic fatty liver patients.

Subjects and Methods: This study was conducted on 140 patients that were randomized either to group 1 that received the standard conventional therapy in addition to placebo or group 2 that received the standard conventional therapy in addition to cholecalciferol during the 4 months study period.

Results: At the end of the study group 2 revealed significant decrease (p < 0.05) in the mean serum level of TG, LDL-C, TC, hsCRP as compared to their baseline results and group 1 results. Additionally, a significant improvement in the serum levels of ALT (p = 0.001) was seen in group 2 at the end of the study when compared to group 1. Whereas group 1 did not show any change in these parameters when compared to group 2 and their baseline results.

Conclusion: Cholecalciferol was shown to have beneficial effects on serum ALT levels, hsCRP levels and lipid profile of NAFLD patients. Clinical Trial Registration: https://prsinfo.clinicaltrials.gov/prs-users-guide.html, identifier NCT05613192.

 Download the PDF from VitaminDWiki

This RCT used 300,000 then 800 IU daily for 3 months

Actual total = 300,000 + 90 X 800 = 372,000 IU

Only raised D level by 6 ng: should have used a much larger maintenance dose, perhaps 50K weekly

Wide range of response to Vitamin D: 50K Vitamin D weekly: rough chart
Image Translates to Before, After, Weekly
Proposed total: 300,000 + 12 X 50,000 = 900,000 IU

NAFLD might be fought by D if the Vitamin D receptor is activated - Sept 2023

Insights into the role of vitamin D in targeting the culprits of non-alcoholic fatty liver disease
Life Sci. 2023 Sep 22;122124. doi: 10.1016/j.lfs.2023.122124 PDF is behind a paywall
Basma A Abdelrahman 1, Aiman S El-Khatib 2, Yasmeen M Attia 1

Vitamin D (VD) is a secosteroid hormone that is renowned for its crucial role in phospho-calcium homeostasis upon binding to the nuclear vitamin D receptor (VDR). Over and above, the pleiotropic immunomodulatory, anti-inflammatory, and metabolic roles VD plays in different disease settings started to surface in the past few decades. On the other hand, a growing body of evidence suggests a correlation between non-alcoholic fatty liver disease (NAFLD) and its progressive inflammatory form non-alcoholic steatohepatitis (NASH) with vitamin D deficiency (VDD) owing to the former's ingrained link with obesity and metabolic syndrome. Accordingly, a better understanding of the contribution of VDR signalling to NAFLD incidence and progression would provide further insights into its diagnosis, treatment modalities, and prognosis, especially since hitherto, no drug for NAFLD has been approved. This review, therefore, sought to set forth the likely contribution of VDR signalling in NAFLD and how it might influence its multiple drivers.

27+ VitaminDWiki pages with NON-ALCOHOLIC or NAFLD in title

This list is automatically updated

Items found: 27
Title Modified
Liver Fibrosis (NAFLD) 5X less if not obese and good Vitamin D - Oct 2023 23 Oct, 2023
NAFLD and Vitamin D - many studies 25 Sep, 2023
NAFLD in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016 21 Aug, 2023
NAFLD weakly associated with low vitamin D – meta-analysis 2013 21 Aug, 2023
Vitamin D is one of only 2 ways to easily prevent NAFLD (380,000 people) – Oct 2021 16 Apr, 2023
Non-alcoholic fatty liver disease: 75 percent of overweight adults and type II diabetics – Aug 2022 16 Jul, 2022
NAFLD not reduced by 1680 IU of vitamin D plus Omega-3 (no surprise) – RCT Jan 2022 24 Jan, 2022
NAFLD was no longer associated with low vitamin D after “adjusting’ for obesity – May 2021 02 Nov, 2021
Liver Inflammation (NAFLD) is prevented by Vitamin D – review May 2015 05 Oct, 2021
Non-Alcoholic Fatty Liver Disease (NAFLD) treated by Vitamin D (20,000 IU weekly after loading dose) – RCT June 2016 05 Oct, 2021
NAFLD somewhat treated in children with 2,000 IU Vitamin D daily – RCT Aug 2021 30 Aug, 2021
Strong association of non alcoholic fatty liver disease and low vitamin D 28 Oct, 2020
Non-alcoholic Fatty Liver Disease (NAFLD) treated by Vitamin D (in rats this time) – Dec 2019 04 Dec, 2019
Non-alcoholic fatty liver disease and the Vitamin D Receptor – editorial Sept 2019 29 Sep, 2019
NAFLD associated with low vitamin D (in children too) – meta-analysis Aug 2019 06 Aug, 2019
Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT April 2018 02 Mar, 2019
Non-alcoholic Fatty Liver Disease (4 in 10 seniors) and Vitamin D 26 Aug, 2018
NAFLD is treated by Vitamin D, Omega-3, Curcumin, Silymarinm, etc. Aug 2018 26 Aug, 2018
Non-Alcoholic Fatty Liver Disease treated by Omega-3 – three meta-analysis 2016-2017 13 Aug, 2017
Non-Alcoholic Fatty Liver Disease treated by Omega-3 – meta-analysis Oct 2016 13 Aug, 2017
Non-alcoholic fatty liver disease associated with much lower vitamin D – Aug 2014 24 Jul, 2016
Non-alcoholic fatty liver disease (NAFLD) reduced somewhat by 50,000 IU vitamin D every 2 weeks – RCT Sept 2014 13 Jul, 2016
Sarcopenia and non-alcoholic fatty liver disease (vitamin D not mentioned) – Sept 2013 07 Mar, 2015
Hepatitis C, non-alcoholic fatty liver disease and vitamin D deficiency – Dec 2014 31 Dec, 2014
Non-alcoholic fatty liver disease associated with low vitamin D – independent of BMI – June 2014 31 Dec, 2014
Fatty liver disease (NAFLD), metabolic syndrome, and perhaps vitamin D – June 2013 24 Mar, 2014
Fatty liver disease (NAFLD) and the importance of vitamin D – Oct 2012 25 Jul, 2013

VitaminDWiki - 12 Intervention studies and Liver

This list is automatically updated

VitaminDWiki - 5 studies of Vitamin D Receptor and Liver

This list is automatically updated

VitaminDWiki – Overview Liver and vitamin D contains

  • Fact: A properly functioning liver is needed for the efficient activation of vitamin D in the body
  • Fact: Liver diseases often result in lower levels of vitamin D
  • Fact: Various pain relievers damage the liver function
  • Fact: Lower levels of vitamin D result in osteoporosis and many other diseases
  • Options with a poorly functioning liver appear to be:
  1. Increased vitamin D (example: 2X more vitamin D if Liver is 1/2 as efficient)
  2. Increase the response you get from vitamin D
  3. Increase sunshine / UVB,
  4. Get the response you get from the sun/UVB
  5. Consider supplementing with Iron - a patented Iron supplement appears to work very well
  6. Get prescription for active form of vitamin D (Calcitriol) which does not need the liver or kidney to get the benefits of vitamin D in the body
  7. Get Calcidiol which does not need the liver
  8. Use Topical Vitamin D - activation by the skin etc does not require the liver

Click on image for ways of getting vitamin D even if Liver is not functioning well

There have been 56583 visits to this page

Attached files

ID Name Comment Uploaded Size Downloads
20319 NAFLD US military.png admin 31 Oct, 2023 123.80 Kb 155
20318 NAFLD.png admin 31 Oct, 2023 173.90 Kb 156
20317 NAFLD children Mercola.pdf admin 31 Oct, 2023 210.25 Kb 78
20272 NAFLD treat.jpg admin 23 Oct, 2023 33.51 Kb 176
20271 NAFLD D, Omega-3_CompressPdf.pdf admin 23 Oct, 2023 480.90 Kb 81
19405 NAFLD RCT.jpg admin 31 Mar, 2023 78.33 Kb 283
19404 loading FLD RCT.pdf admin 31 Mar, 2023 991.61 Kb 147