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450,000 IU of vitamin D over 9 weeks given to 100,000 teenage Iranian girls helped their livers – Feb 2019

High dose vitamin D supplementation is associated with an improvement in serum markers of liver function

BioFactors https://doi.org/10.1002/biof.1496
Hamidreza Tavakoli Hossein Rostami Amir Avan Mohammad Bagherniya Gordon A. Ferns
Sayyed Saeid Khayyatzadeh khayyatzadeh at yahoo.com, Majid Ghayour‐Mobarhan ghayourmobarhan at yahoo.com;


This appears to be the first study of the affects of high-dose vitamin D given to 100,000 Iranian girls. In early 2015
9.4 ng of Vitamin D+ 9 weeks of 50,000 IU/week ==> 36.4 ng
What other studies will be published on this massive intervention?
Hopefully Iran will continue to give the girls 50,000 IU every two weeks as a maintenance dose
Hopefully the Vitamin D measurement was done at least 4 days after the last dose
If so, suspect that the Vitamin D levels will have plateaued at about 50 ng at 20 weeks
Of the 100,000 girls, 988 were studied to see changes in liver function
Did not notice % of girls with poor livers and % with OK livers

From Wikipedia

Age group Number(2011)
10–14 5,671,435
15–19 6,607,043

12 million over a 9 year age group in 2011
Probably 6 million girls in 9 year age group
Perhaps 4 million in a 6 year age group
So 100,000 girls = 2.5% of that age group
Thus Iran gave 450,000 IU to 2.5% of their teenage girls in 2015

Overview Liver and vitamin D contains the following summary

  • Fact: A properly functioning liver is needed for the efficient activation of vitamin D in the body
  • Fact: Liver diseases often result in lower levels of vitamin D
  • Fact: Various pain relievers damage the liver function
  • Fact: Lower levels of vitamin D result in osteoporosis and many other diseases
  • Options with a poorly functioning liver appear to be:
  1. Increased vitamin D (example: 2X more vitamin D if Liver is 1/2 as efficient)
  2. Increase the response you get from vitamin D
  3. Increase sunshine / UVB,
  4. Get the response you get from the sun/UVB
  5. Consider supplementing with Iron - a patented Iron supplement appears to work very well
  6. Get prescription for active form of vitamin D (Calcitriol) which does not need the liver or kidney to get the benefits of vitamin D in the body
  7. Get Calcidiol which does not need the liver
  8. Use Topical Vitamin D - activation by the skin etc does not require the liver

Click on image for ways of getting vitamin D even if Liver is not functioning well

Note: 300,000 IU is a typical loading dose for teens
Overview Loading of vitamin D contains the following

Loading dose: 199 studies at VitaminDWiki

Vitamin D loading dose (stoss therapy) proven to improve health overview
If a person is or is suspected to be, very vitamin D deficient a loading dose should be given

  • Loading = restore = quick replacement by 1 or more doses
  • Loading doses range in total size from 100,000 IU to 1,000,000 IU of Vitamin D3
    • = 2.5 to 25 milligrams
  • The size of the loading dose is a function of body weight - see below
    • Unfortunately, some doctors persist in using Vitamin D2 instead of D3
  • Loading may be done as quickly as a single day (Stoss), to as slowly as 3 months.
    • It appears that spreading the loading dose over 4+ days is slightly better if speed is not essential
  • Loading is typically oral, but can be Injection (I.M,) and Topical
  • Loading dose is ~3X faster if done topically or swished inside of the mouth
    • Skips the slow process of stomach and intestine, and might even skip liver and Kidney as well
  • The loading dose persists in the body for 1 - 3 months
    • The loading dose should be followed up with on-going maintenance dosing
    • Unfortunately, many doctors fail to follow-up with the maintenance dosing.
  • About 1 in 300 people have some form of a mild allergic reaction to vitamin D supplements, including loading doses
    • it appears prudent to test with a small amount of vitamin D before giving a loading dose
    • The causes of a mild allergic reaction appear to be: (in order of occurrence)
    • 1) lack of magnesium - which can be easily added
    • 2) allergy to capsule contents - oil, additives (powder does not appear to cause any reaction)
    • 3) allergy to the tiny amount of D3 itself (allergy to wool) ( alternate: D3 made from plants )
    • 4) allergy of the gut to Vitamin D - alternative = topical

Middle East and Vitamin D contains the following summary

151 items in Middle East category
see also Overview Middle East and vitamin D


 Download the PDF from Sci-hub via VitaminDWiki

Limited studies have examined the effects of vitamin D on liver enzymes in patients with liver disease but none has explored its effects in the healthy subjects. The aim of present study was to evaluate the effects of a high dose vitamin D supplementation on measures of liver function. A total of 988 adolescent girls were recruited; all were assessed for liver function tests (LFTs) including alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), gamma‐glutamyl transferase (ϒGT), alkaline phosphatase (ALP), total bilirubin, direct bilirubin, albumin, and total protein before and after supplementation with 50,000 IU cholecalciferol perls. Significant reductions were observed for AST, ALT, direct bilirubin, total bilirubin, LDH, and ϒGT at the end of supplementation, only in the group with abnormal reference value. Serum levels of total protein and albumin were higher at the end of follow up in the group with abnormal value.
No significant change was obtained for LFTs in the group with normal value. Our findings suggest that vitamin D supplementation may improve markers of liver function in adolescents with abnormal LFTs. More randomized controlled trial with longer follow‐up time will be required.

Created by admin. Last Modification: Friday October 29, 2021 10:36:10 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
11386 Iran Liver T3.jpg admin 14 Feb, 2019 107.04 Kb 614
11385 High-dose liver.pdf admin 14 Feb, 2019 240.68 Kb 602