Vitamin D alleviates non-alcoholic fatty liver disease via restoring gut microbiota and metabolism
Front. Microbiol., Volume 14 - 2023 | https://doi.org/10.3389/fmicb.2023.1117644
\r\nXiao-Lei Zhang&#x;Xiao-Lei Zhang1†Lei Chen,,&#x;Lei Chen2,3,4†Jiang YangJiang Yang1Shan-Shan Zhao,,Shan-Shan Zhao2,3,4Shi JinShi Jin1Na AoNa Ao1Jing Yang,,Jing Yang2,3,4Hui-Xin Liu,,,*Hui-Xin Liu1,2,3,4*Jian Du*Jian Du1*
1Department of Endocrinology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China
2Institute of Health Sciences, China Medical University, Shenyang, Liaoning, China
3Institute of Life Sciences, China Medical University, Shenyang, Liaoning, China
4Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, Liaoning, China
Background: Non-alcoholic fatty liver disease (NAFLD) represents a severe public health problem. Dysbiosis of gut microbiome has been identified as one of the key environmental factors contributing to NAFLD. As an essential nutrition, Vitamin D (VD) plays an important role in regulating gut microbiota based on its receptor (Vitamin D Receptor, VDR) which is highly expressed in the gastrointestinal tract.
Methods: Rats were fed with HFD (high-fat diet) for 12 weeks. And the rats were treated with VD two times a week by intraperitoneal injection for 12 weeks. H&E staining combined with plasma biochemical index was performed to characterize pathological changes and function of the liver. Fecal microbiota 16S rRNA gene sequencing and metabolomics were taken to reveal the altered gut microbiota and metabolites.
Result: The VD alleviates the HFD-induced lipid accumulation in the liver as well as decreases the levels of amlodipine besylate (ALT) and amlodipine aspartate (AST). VD supplement decreased the ratio of phylum Firmicutes/Bacteroidetes (F/B) but increased alpha diversity. In addition, the VD treatment improved the HFD-induced gut microbiota by increasing the Prevotella and Porphyromonadaceae and decreasing Mucispirillum, Acetatifactor, Desulfovibrio, and Oscillospira abundance. Furthermore, the capability of tyrosine metabolism, tryptophan metabolism, arginine biosynthesis, and sphingolipid metabolism was enhanced after VD treatment. Consistently, Prevotella positively correlated with tryptophan metabolism and sphingolipid metabolism. Importantly, the Prevotella abundance was positively associated with serotonin, melatonin, tryptamine, L-arginine, and 3-dehydrosphinganine which synthesize from tryptophan, tyrosine, arginosuccinate, and serine, respectively.
Conclusion: VD treatment inhibited HFD-induced NAFLD accompany by dysbiosis gut microbiota and metabolites, suggesting that VD supplement could be a potential intervention used for NAFLD treatment by targeting the specific microbiota
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VitaminDwiki – Microbiome contains
Some of the- Nutrients, Microbiome, and Chronic Diseases - April 2023
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- Healthy microbiota might reduce COVID-19 – several studies
- Poor absorption of Vitamin D is strongly related to type of gut bacteria – Dec 2020
- Vitamin D and the Host-Gut Microbiome: A Brief Overview– June 2020
- Parkinson's Disease and gut microbiome - several studies
- Vitamin D levels change Gut Microbiota – 25 study review Sept 2021
- Gut Microbiota: improved by Vitamin D – narrative review – July 2021
- Gut microbiome massively changed by weekly vitamin D – July 2015
- Also: Google Scholar on Microbiome includes:The cancer microbiome - June 2019, The Healthy Microbiome—What Is the Definition of a Healthy Gut Microbiome? - Jan 2021, The gut microbiome in neurological disorders - Feb 2020, Understanding the role of the gut microbiome in gastrointestinal cancer: A review -Jan 2023, The human microbiome and COVID-19: A systematic review - June 2021, *Interaction between drugs and the gut microbiome - July 2020
VitaminDwiki – NAFLD and Vitamin D - many studies
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