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Non-alcoholic Fatty Liver Disease (NAFLD) treated by Vitamin D (in rats this time) – Dec 2019

Active vitamin D impedes the progression of non-alcoholic fatty liver disease by inhibiting cell senescence in a rat model

Clinics and Research in Hepatology and Gastroenterology, https://doi.org/10.1016/j.clinre.2019.10.007


Items in both categories Liver and Intervention are listed here: give vitamin D and see what happens

Items in both categories Liver and Omega-3 are listed here:

Overview Liver and vitamin D contains the following summary

  • Fact: A properly functioning liver is needed for the efficient activation of vitamin D in the body
  • Fact: Liver diseases often result in lower levels of vitamin D
  • Fact: Various pain relievers damage the liver function
  • Fact: Lower levels of vitamin D result in osteoporosis and many other diseases
  • Options with a poorly functioning liver appear to be:
  1. Increased vitamin D (example: 2X more vitamin D if Liver is 1/2 as efficient)
  2. Increase the response you get from vitamin D
  3. Increase sunshine / UVB,
  4. Get the response you get from the sun/UVB
  5. Consider supplementing with Iron - a patented Iron supplement appears to work very well
  6. Get prescription for active form of vitamin D (Calcitriol) which does not need the liver or kidney to get the benefits of vitamin D in the body
  7. Get Calcidiol which does not need the liver
  8. Use Topical Vitamin D - activation by the skin etc does not require the liver

Click on image for ways of getting vitamin D even if Liver is not functioning well

Non-alcoholic fatty liver disease (NAFLD) refers to an accumulation of excess fat in liver due to causes other than alcohol use. The relationship between vitamin D (VD) and NAFLD has been previously studied. Therefore, we aimed to explore the mechanism involved active VD regulating the progression of NAFLD by inhibiting cell senescence and to provide a potential approach for further nutritional treatment of NAFLD.

Following the induction with high-fat diet and intraperitoneal injection of corn oil, the successfully established NAFLD rat models were treated with 1,25(OH)2D3 at 1 μg/kg, 5 μg/kg or 10 μg/kg. Meanwhile, the levels of factors related to oxidative stress, cell senescence, the p53-p21 signaling pathway and inflammation in liver were determined. Then, cell senescence was also measured by using senescence-associated β-galactosidase (SAβ-gal) staining.

It was also found that active VD increased the concentration of VD in serum and VDR in liver of NAFLD rats, and alleviated hepatic fibrosis. Besides, treatment of 1,25(OH)2D3 at 1 μg/kg, 5 μg/kg or 10 μg/kg reduced oxidative stress and inflammation, inhibited the p53-p21 signaling pathway and consequent cell senescence. Furthermore, treatment of 1,25(OH)2D3 at a dosage of 5 μg/kg made the most impact on these factors.

Collectively, the evidences from this study demonstrated that active VD could alleviate the development of NAFLD through blocking the p53-p21 signaling pathway, which provided a novel nutritional therapeutic insight for NAFLD.

Created by admin. Last Modification: Wednesday October 28, 2020 14:39:54 GMT-0000 by admin. (Version 3)
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