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NAFLD not reduced by 1680 IU of vitamin D plus Omega-3 (no surprise) – RCT Jan 2022


The effects of fish oil plus vitamin D3 intervention on non-alcoholic fatty liver disease: a randomized controlled trial

European Journal of Nutrition (2022) https://doi.org/10.1007/s00394-021-02772-0
Xiao-fei Guo, Chong Wang, Ting Yang, Wen-jun Ma, Jie Zhai, Ting Zhao, Tong-cheng Xu, Jun Li, He Liu, Andrew J. Sinclair & Duo Li

Purpose
The present study aimed to investigate fish oil plus vitamin D3 (FO + D) supplementation on biomarkers of non-alcoholic fatty liver disease (NAFLD).

Methods
In a 3-month randomized controlled trial, 111 subjects with NAFLD, aged 56.0 ± 15.9 y, were randomized into FO + D group (n = 37), fish oil group (FO, n = 37) or corn oil group (CO, n = 37). The subjects consumed the following capsules (3 g/day), which provided 2.34 g/day of eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) + 1680 IU vitamin D3 (FO + D group), or 2.34 g/day of EPA + DHA (FO group), or 1.70 g/d linoleic acid (CO group).

Results
Using multivariable-adjusted general linear model, there were significant net reductions in serum alanine aminotransferase (ALT), and triacylglycerol (TAG) and TNF-α levels in the FO + D and FO groups, compared with the control group (P < 0.05). The supplemental FO + D also showed significant reductions in insulin (− 1.58 ± 2.00 mU/L vs. − 0.63 ± 1.55 mU/L, P = 0.050) and IL-1β (− 6.92 ± 7.29 ng/L vs. 1.06 ± 5.83 ng/L, P < 0.001) in comparison with control group. Although there were no significant differences between FO + D and FO groups regarding biochemical parameters, supplemental FO + D showed decreases in ALT (from 26.2 ± 13.5 U/L to 21.4 ± 9.6 U/L, P = 0.007), aspartate aminotransferase (AST, from 22.5 ± 7.0 U/L to 20.2 ± 4.0 U/L, P = 0.029), HOMA-IR (from 3.69 ± 1.22 to 3.38 ± 1.10, P = 0.047), and TNF-α (from 0.43 ± 0.38 ng/L to 0.25 ± 0.42 ng/L, P < 0.001) levels following the intervention.

Conclusion
The present study demonstrated that groups supplemented with FO + D and FO had similar beneficial effects on biomarkers of hepatocellular damage and plasma TAG levels in subjects with NAFLD, while in the FO + D group, there were some suggestive additional benefits compared with FO group on insulin levels and inflammation.

Trial registration ChiCTR1900024866.


VitaminDWiki pages with NON-ALCOHOLIC or NAFLD in title (22 as of Jan 2022)

This list is automatcially updated

Items found: 27
Title Modified
Liver Fibrosis (NAFLD) 5X less if not obese and good Vitamin D - Oct 2023 23 Oct, 2023
NAFLD and Vitamin D - many studies 25 Sep, 2023
NAFLD in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016 21 Aug, 2023
NAFLD weakly associated with low vitamin D – meta-analysis 2013 21 Aug, 2023
Vitamin D is one of only 2 ways to easily prevent NAFLD (380,000 people) – Oct 2021 16 Apr, 2023
Non-alcoholic fatty liver disease: 75 percent of overweight adults and type II diabetics – Aug 2022 16 Jul, 2022
NAFLD not reduced by 1680 IU of vitamin D plus Omega-3 (no surprise) – RCT Jan 2022 24 Jan, 2022
NAFLD was no longer associated with low vitamin D after “adjusting’ for obesity – May 2021 02 Nov, 2021
Liver Inflammation (NAFLD) is prevented by Vitamin D – review May 2015 05 Oct, 2021
Non-Alcoholic Fatty Liver Disease (NAFLD) treated by Vitamin D (20,000 IU weekly after loading dose) – RCT June 2016 05 Oct, 2021
NAFLD somewhat treated in children with 2,000 IU Vitamin D daily – RCT Aug 2021 30 Aug, 2021
Strong association of non alcoholic fatty liver disease and low vitamin D 28 Oct, 2020
Non-alcoholic Fatty Liver Disease (NAFLD) treated by Vitamin D (in rats this time) – Dec 2019 04 Dec, 2019
Non-alcoholic fatty liver disease and the Vitamin D Receptor – editorial Sept 2019 29 Sep, 2019
NAFLD associated with low vitamin D (in children too) – meta-analysis Aug 2019 06 Aug, 2019
Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT April 2018 02 Mar, 2019
Non-alcoholic Fatty Liver Disease (4 in 10 seniors) and Vitamin D 26 Aug, 2018
NAFLD is treated by Vitamin D, Omega-3, Curcumin, Silymarinm, etc. Aug 2018 26 Aug, 2018
Non-Alcoholic Fatty Liver Disease treated by Omega-3 – three meta-analysis 2016-2017 13 Aug, 2017
Non-Alcoholic Fatty Liver Disease treated by Omega-3 – meta-analysis Oct 2016 13 Aug, 2017
Non-alcoholic fatty liver disease associated with much lower vitamin D – Aug 2014 24 Jul, 2016
Non-alcoholic fatty liver disease (NAFLD) reduced somewhat by 50,000 IU vitamin D every 2 weeks – RCT Sept 2014 13 Jul, 2016
Sarcopenia and non-alcoholic fatty liver disease (vitamin D not mentioned) – Sept 2013 07 Mar, 2015
Hepatitis C, non-alcoholic fatty liver disease and vitamin D deficiency – Dec 2014 31 Dec, 2014
Non-alcoholic fatty liver disease associated with low vitamin D – independent of BMI – June 2014 31 Dec, 2014
Fatty liver disease (NAFLD), metabolic syndrome, and perhaps vitamin D – June 2013 24 Mar, 2014
Fatty liver disease (NAFLD) and the importance of vitamin D – Oct 2012 25 Jul, 2013

VitaminDWiki - in both Liver and Omega-3 categories (6 as of Jan 2022)