The association of vitamin D deficiency with non-alcoholic fatty liver disease.
Clinics (Sao Paulo). 2014 Aug;69(8):542-6.
Küçükazman M1, Ata N2, Dal K2, Yeniova AÖ1, Kefeli A1, Basyigit S1, Aktas B1, Akin KO3, Ağladıoğlu K4, Üre ÖS2, Topal F5, Nazligül Y1, Beyan E2, Ertugrul DT6.
Author information
1Department of Gastroenterology, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
2Department of Internal Medicine, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
3Department of Clinical Biochemistry, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
4Department of Radiology, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
5Department of Gastroenterology, Ankara Oncology Teaching and Research Hospital, Ankara, Turkey.
6Department of Endocrinology and Metabolism, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
Good Vitamin D blood levels require healthy liver and kidney
NAFLD is an indication of an unhealthy liver
See also VitaminDWiki
Overview Liver and vitamin D contains the following summary
- Fact: A properly functioning liver is needed for the efficient activation of vitamin D in the body
- Fact: Liver diseases often result in lower levels of vitamin D
- Fact: Various pain relievers damage the liver function
- Fact: Lower levels of vitamin D result in osteoporosis and many other diseases
- Options with a poorly functioning liver appear to be:
- Increased vitamin D (example: 2X more vitamin D if Liver is 1/2 as efficient)
- Increase the response you get from vitamin D
- Increase sunshine / UVB,
- Get the response you get from the sun/UVB
- Consider supplementing with Iron - a patented Iron supplement appears to work very well
- Get prescription for active form of vitamin D (Calcitriol) which does not need the liver or kidney to get the benefits of vitamin D in the body
- Get Calcidiol which does not need the liver
- Use Topical Vitamin D - activation by the skin etc does not require the liver
Click on image for ways of getting vitamin D even if Liver is not functioning well
Strong association of non alcoholic fatty liver disease and low vitamin D
OBJECTIVE:
Vitamin D deficiency has been related to diabetes, hypertension, hyperlipidemia and peripheral vascular disease. In this study, we aimed to investigate the role of vitamin D status in non-alcoholic fatty liver disease.
METHODS:
We included 211 consecutive subjects to examine the presence of non-alcoholic fatty liver disease. Of these subjects, 57 did not have non-alcoholic fatty liver disease and 154 had non-alcoholic fatty liver disease.
RESULTS:
The non-alcoholic fatty liver disease group had significantly higher fasting blood glucose (p = 0.005), uric acid (p = 0.001), aspartate aminotransferase (p<0.001), alanine aminotransferase (p<0.001), γ-glutamyltransferase (p<0.0001), alkaline phosphatase (p = 0.028), HbA1c (p<0.001), ferritin (p<0.001), insulin (p = 0.016), C-peptide (p = 0.001), HOMA-IR (p = 0.003), total cholesterol (p = 0.001), triglyceride (p = 0.001) and white blood cell (p = 0.04) levels. In contrast, the non-alcoholic fatty liver disease group had significantly lower 25(OH)D levels (12.3±8.9 ng/dl, p<0.001) compared with those of the control group (20±13.6 ng/dl).
CONCLUSIONS:
In this study, we found lower serum 25(OH)D levels in patients with non-alcoholic fatty liver disease than in subjects without non-alcoholic fatty liver disease. To establish causality between vitamin D and non-alcoholic fatty liver disease, further interventional studies with a long-term follow-up are needed.
PMID: 25141113