The Level of Vitamin D in Children and Adolescents with Nonalcoholic Fatty Liver Disease: A Meta-Analysis.
Zhu S#1, Wang Y#2, Luo F1, Liu J1, Xiu L1, Qin J3, Wang T2, Yu N2, Wu H4, Zou T1.
Items in both categories Liver and Meta-analysis are listed here:
- NAFLD associated with low vitamin D (in children too) – meta-analysis Aug 2019
- Hepatitis B patients have 2 ng lower level of Vitamin D – meta-analysis June 2019
- Non-Alcoholic Fatty Liver Disease treated by Omega-3 – three meta-analysis 2016-2017
- Fatty liver disease weakly associated with low vitamin D – meta-analysis 2013
Liver and Intervention: give vitamin D and see what happens
- NAFLD is treated by Vitamin D, Omega-3, Curcumin, Silymarinm, etc. Aug 2018
- Alcoholic liver cirrhosis treated by 1,000 IU of vitamin D – July 2018
- Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT April 2018
- Weekly dosing of vitamin D is far better than single large dose (chronic liver, children) – March 2018
- Fatty liver disease in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016
- Non-Alcoholic Fatty Liver Disease (NAFLD) treated by Vitamin D (20,000 IU weekly after loading dose) – RCT June 2016
- Non-alcoholic fatty liver disease (NAFLD) reduced somewhat by 50,000 IU vitamin D every 2 weeks – RCT Sept 2014
- 400,000 IU barely raised liver transplant candidate vitamin D levels (no surprise) – March 2015
- Hepatitis-C both treated and prevented by Vitamin D (many studies)
The relationship between vitamin D level and NAFLD has not been investigated in children and adolescents. We performed a meta-analysis of published observational studies to assess this association between vitamin D levels (measured as serum 25-hydroxy vitamin D [25(OH)D]) and NAFLD in this age group.
Relevant studies conducted before May 20, 2018, were identified from the following electronic databases: PubMed, the Cochrane Library, Embase, and the Chinese CNKI databases. The quality of the included studies was evaluated using the Newcastle Ottawa Scale, and associations between vitamin D levels and NAFLD were estimated using standardised mean differences (SMD) and 95% confidence interval (CI). Subgroup and sensitivity analysis were used to identify sources of heterogeneity, and publication bias was evaluated using funnel plots.
Eight articles were included in this meta-analysis. A significant difference was observed between low 25(OH)D levels and NAFLD in children and adolescents (SMD = -0.59, 95%CI = -0.98, -0.20, P < 0.01). Subgroup analysis revealed no differences in the study type, geographic location, BMI, and age subgroups.
Low vitamin D levels were associated with NAFLD in children and adolescents.