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Clinically Isolated Syndrome progresses to Multiple Sclerosis, unless UVB treatments – RCT Dec 2017

Ultraviolet light offers MS relief

  • “The trial, funded by MSWA, was carried out in 20 people with a clinically isolated syndrome — the first signs of a disease that could be MS but had yet to progress. All had sufficient levels of vitamin D.”
  • “In the half of people given narrowband UVB treatment three times a week for eight weeks, only 30 per cent progressed to MS.”    vs 100% progressed without UVB

MS has been seen to benefit from UV more than Vitamin D in many previous studies
VitaminDWiki suspects that something in addition to Vitamin D is made by UVB
Unaware of UVB being "better" than vitamin D for any other health problems

Items in both categories UV and Multiple Sclerosis are listed here:

See also Web


Previously published description of the trial

Narrowband UVB Phototherapy for Clinically Isolated Syndrome: A Trial to Deliver the Benefits of Vitamin D and Other UVB-Induced Molecules.
Front Immunol. 2017 Jan 24;8:3. doi: 10.3389/fimmu.2017.00003. eCollection 2017.
Hart PH 1 prue.hart at telethonkids.org.au, Lucas RM2, Booth DR3, Carroll WM4, Nolan D5, Cole JM6, Jones AP1, Kermode AG7.

Low vitamin D and insufficient sun exposure are additive independent risk factors for the development of multiple sclerosis (MS). The usual measure of vitamin D status, serum 25-hydroxy vitamin D [25(OH)D], is also a marker of recent exposure to the UVB rays of sunshine. The main evidence for a protective effect for MS development of higher 25(OH)D comes from observational studies, but this study design cannot separate out whether 25(OH)D is acting as a marker of vitamin D status, sun exposure, or both. In light of a lack of definitive outcomes in MS patients after trials of vitamin D supplementation and the ability of narrowband UVB to induce vitamin D, as well as other immune-regulatory molecules in skin, the Phototherapy for Clinically Isolated Syndrome (PhoCIS) trial was established to investigate the benefits of narrowband UVB, in addition to supplemented vitamin D, on MS development in individuals with Clinically Isolated Syndrome. We propose that the PhoCIS trial provides a fresh approach to re-defining the reported associations of 25(OH)D levels with MS development and progression.

PMID: 28167940    Download the PDF from VitaminDWiki

Created by admin. Last Modification: Thursday January 4, 2018 19:40:18 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
8951 CIS to MS.jpg admin 17 Dec, 2017 19.00 Kb 761
8950 UV MS trial.pdf admin 17 Dec, 2017 216.50 Kb 612
8949 CIS UV MS trial.jpg admin 17 Dec, 2017 13.44 Kb 1683