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Multiple Sclerosis helped by UV – possibly via cytokines, etc. – Oct 2015

Ultraviolet radiation, vitamin D and multiple sclerosis.

Neurodegener Dis Manag. 2015 Oct;5(5):413-24. doi: 10.2217/nmt.15.33. Epub 2015 Oct 19.
Lucas RM 1,2, Byrne SN 3, Correale J 4, Ilschner S 5, Hart PH2.
1National Centre for Epidemiology & Population Health, Research School of Population Health, The Australian National University, Canberra, Australia.
2Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.
3Sydney Medical School, University of Sydney, Sydney, Australia.
4Department of Neurology, Raul Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina.
5Independent researcher.

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The items in both categories MS and UV are listed here:

The items in both categories MS and Inflammation are listed here:

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There is compelling epidemiological evidence that the risk of developing multiple sclerosis is increased in association with low levels of sun exposure, possibly because this is associated with low vitamin D status. Recent work highlights both vitamin D and non-vitamin D effects on cellular immunity that suggests that higher levels of sun exposure and/or vitamin D status are beneficial for both MS risk and in ameliorating disease progression.
Here we review this recent evidence, focusing on regulatory cells, dendritic cells, and chemokines and cytokines released from the skin following exposure to ultraviolet radiation.

KEYWORDS: B regulatory cells; cis-urocanic acid; dendritic cells; multiple sclerosis; ultraviolet radiation; vitamin D

PMID: 26477548 DOI: 10.2217/nmt.15.33

Table 2. Uv-regulated cytokines and their possible role in multiple sclerosis.

Cytokine

Uv-induced trigger

Main cutaneous source

Possible role in MS

Upregulated

IL-10

DNAdamage

Epithelial cells

Anti-inflammatory

Vitamin D

Dendritic cells

Lowers TNF

Mast cells

Increases T„    [117]

IL-1P

ATP? Caspase? [118]

Macrophages

Proinflammatory

Keratinocytes

Increases permeability of the blood-brain barrier [119]

IL-6

DNA damage

Keratinocytes [120]

Proinflammatory

T-cells

Macrophages

Fibroblasts

Increases Th17 [121]

IL-8

UV-B

Fibroblasts [122]

Reduced by IFN-P treatment [123]

Topical 1,25(OH)D inhibits release [124]

Keratinocytes

Mast cells

GM-CSF

DNA damage

T cells

Macrophages Keratinocytes [126]

Associated with relapses [125]

TNF

IL-1

Macrophages

Mast cells

T cells

Keratinocytes [127]

Proinflammatory

IL-33

Platelet activating factor

Fibroblasts [114]

Paradoxically elevated in MS patients [128]

Keratinocytes [114]

Attenuates EAE by suppressing IL-17 and IFN [129]

Downregulated

IFN-y

Cytokine signaling molecules 1 and

3 [130]

Keratinocytes

Macrophage/microglia stimulation

Il-17/23

Transcriptional modulation, IL-6 [118]

Th 17 cells

Expressed in brain lesions of MS patients; induces expression of inflammatory genes in astrocytes [131]

Keratinocytes

DC: Dendritic cell; MS: Multiple sclerosis.

Attached files

ID Name Comment Uploaded Size Downloads
7046 UV MS.pdf PDF 2016 admin 07 Sep, 2016 14:45 1.47 Mb 255
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