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Faster heart rate and higher systolic blood pressure associated with low vitamin D – Jan 2010

Relation of serum 25-hydroxyvitamin D to heart rate and cardiac work
(from the National Health and Nutrition Examination Surveys).

Am J Cardiol. 2010 Jan 1;105(1):122-8. doi: 10.1016/j.amjcard.2009.08.661. Epub 2009 Nov 14.
Scragg RK, Camargo CA Jr, Simpson RU.
University of Auckland, Auckland, New Zealand. r.scragg at auckland.ac.nz

Vitamin D may protect against cardiovascular disease, but its association with cardiac function is unclear. The aim of this study was to examine the associations of serum 25-hydroxyvitamin D (25OHD) with heart rate, systolic blood pressure, and the rate-pressure product (RPP). Data analyses were carried out on 27,153 participants aged > or =20 years, with measurements of serum 25(OH)D, heart rate (from radial pulse), and systolic blood pressure, in the National Health and Nutrition Examination Surveys (NHANES) carried out from 1988 to 1994 and from 2001 to 2006. RPP was calculated as heart rate times systolic blood pressure. Results were adjusted for age, gender, race or ethnicity, body mass index, physical activity, tobacco smoking, co-morbidities, and blood pressure treatment. Compared to participants with 25(OH)D > or =35 ng/ml, the adjusted mean +/- SE heart rate was significantly (p <0.001) higher, by 2.1 +/- 0.6 beats/min, in participants with 25(OH)D <10.0 ng/ml, while mean systolic blood pressure was 1.9 +/- 0.8 mm Hg higher (p <0.05) for participants with 25(OH)D <10.0 ng/ml and 1.7 +/- 0.6 mm Hg higher (p <0.01) for those with 25(OH)D of 10.0 to 14.9 ng/ml. As a consequence, adjusted mean RPP was 408 +/- 110 beats/min . mm Hg higher (p <0.001) for participants with 25(OH)D <10.0 ng/ml and 245 +/- 80 beats/min . mm Hg higher (p <0.01) for participants with 25(OH)D of 10.0 to 14.9 ng/ml, compared to those with 25(OH)D > or =35 ng/ml. In conclusion, these results show that low serum 25(OH)D levels are associated with increased heart rate, systolic blood pressure, and RPP and suggest that low vitamin D status may increase cardiac work. Vitamin D intervention studies are required to confirm these findings.

PMID: 20102903\


Summary by VitaminDWiki

27,000 people in New Zealand
Compared vitamin D levels <10 ng to >35 ng
Heart rate 2 beats faster
Systolic blood pressure 2 mm Hg higher

See also VitaminDWiki

See also web

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    Compared with men <50 beats/minute,
    71 - 80 beats had a 1.5X greater risk of death
    81 - 90 beats, had a 2X greater risk of death
    90+ beats had a 3X greater risk of death
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