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Crohn’s Disease risk increased 3 X if inadequate vitamin D level (another form is needed) – Oct 2017

The Association of Vitamin D Status with Disease Activity in a Cohort of Crohn’s Disease Patients in Canada

Nutrients 2017, 9(10), 1112; doi:10.3390/nu9101112, Published: 12 October 2017


Poor guts need different forms of vitamin D

Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol
D - Slow
C -Fast
10 Sun/UVBSlowLong
(skin patch/cream, vagina)
Fast nano
9Nanoemulsion -mucosal
perhaps activates VDR
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
(some goes into gut)
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

Getting Vitamin D into your body has the following chart


Gut category listing contains the following

170 items in GUT category - see also Overview Gut and vitamin D,

 Download the PDF from VitaminDWiki

Dania Alrefai 1, Jennifer Jones 2, Wael El-Matary 3, Susan J. Whiting 1OrcID, Abdulrahman Aljebreen 4, Naghmeh Mirhosseini 5OrcID and Hassan Vatanparast 1,* OrcID
1 College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada
2 Division of Digestive Care & Endoscopy, Department of Community Health and Epidemiology, Dalhousie University, Truro, NS B2N 5E3, Canada
3 College of Medicine, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
4 College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia
5 Pure North S’Energy Foundation, Calgary, AB T2R 0C5, Canada
*Author to whom correspondence should be addressed.

We determined the association between vitamin D status as 25hydroxyvitamin D [25(OH)D] and disease activity in a cohort of 201 Crohn’s Disease (CD) patients in Saskatoon, Canada over three years. The association between high-sensitivity C-reactive protein (hs-CRP) and 25(OH)D and several disease predictors were evaluated by the generalized estimating equation (GEE) over three time-point measurements. A GEE binary logistic regression test was used to evaluate the association between vitamin D status and the Harvey-Bradshaw Index (HBI). The deficient vitamin D group (≤29 nmol/L) had significantly higher mean hs-CRP levels compared with the three other categories of vitamin D status (p < 0.05). CRP was significantly lower in all of the other groups compared with the vitamin D-deficient group, which had Coef. = 12.8 units lower (95% CI −19.8, −5.8), Coef. 7.85 units (95% CI −14.9, −0.7), Coef. 9.87 units (95% CI −17.6, −2.0) for the vitamin D insufficient, adequate, and optimal groups, respectively. The vitamin D status was associated with the HBI active disease category.
However, the difference in the odds ratio compared with the reference category of deficient vitamin D category was only significant in the insufficient category (odds ratio = 3.45, p = 0.03, 95% CI 1.0, 10.8). Vitamin D status was inversely associated with indicators of disease activity in Crohn’s disease, particularly with the objective measures of inflammation.

Created by admin. Last Modification: Thursday October 12, 2017 13:56:42 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
8537 Crohn’s 3 X more likely if vitamin D insufficient.pdf PDF 2017 admin 12 Oct, 2017 13:40 281.74 Kb 371
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