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Colorectal cancer is associated with Vitamin D (17 meta-analyses so far) – July 2018

Association between Blood 25-Hydroxyvitamin D Levels and Survival in Colorectal Cancer Patients: An Updated Systematic Review and Meta-Analysis.

Nutrients. 2018 Jul 13;10(7). pii: E896. doi: 10.3390/nu10070896.
Maalmi H1,2, Walter V3, Jansen L4, Boakye D5, Schöttker B6,7, Hoffmeister M8, Brenner H9,10,11.

VitaminDWiki

This again has documented the association of Colorectal Cancer with Vitamin D
This study, like many of the previous ones, asks for trials to be run to see that is it more than an association
Clinical trials are listed for Colorectal Cancer and Vitamin D 18 as of July 2018
Most of the trials deal with TREATMENT, not PREVENTION.
Most of the trials are still underway, and it appears that none of been published as of July 2018

I anticipate that someone will do a re-analysis of a long-term clinical trial which used high dose vitamin D for some other health problem. Suspect that they will be able to find a decrease in colorectal cancer in the elderly group which got high dose vitamin D for > 5 years.
   Henry Lahore, founder of VitaminDWiki


Cancer - Colon category starts with the following

All Items in both Cancer- Coion and Meta-analysis are listed here:

 Download the PDF from VitaminDWiki

Image

Previous meta-analyses have shown an improved survival with higher blood 25-hydroxyvitamin D (25(OH)D) concentrations in patients with colorectal cancer (CRC). However, a number of much larger studies have been published since then. We provide an updated meta-analysis to synthesize current evidence. PubMed and Web of Science databases were systematically searched for eligible studies. The dose-response relationships and pooled hazard ratios for overall and CRC-specific survival comparing the highest versus the lowest categories of blood 25(OH)D concentrations were assessed. Subgroup analyses based on study geographic location, year of publication, sample size, length of follow-up time and stage were conducted to explore potential sources of heterogeneity.
Overall, 11 original studies with a total of 7718 CRC patients were included. The dose-response meta-analysis showed an improvement in survival outcomes with increasing blood 25(OH)D concentrations. Pooled hazard ratios (95% confidence intervals) comparing highest versus lowest categories were 0.68 (0.55⁻0.85) and 0.67 (0.57⁻0.78) for overall and CRC-specific survival, respectively. Associations were more prominent among studies conducted in Europe, with larger sample sizes, and including stage I⁻IV patients. This updated meta-analysis reveals robust evidence of an association between higher blood 25(OH)D concentrations and better survival in CRC patients. The potential for enhancing prognosis of CRC patients by vitamin D supplementation should be explored by randomized trials.

Created by admin. Last Modification: Friday August 23, 2019 12:00:21 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
10208 CRC survival.jpg admin 18 Jul, 2018 11:47 33.82 Kb 303
10207 17th CRC meta-analysis.pdf PDF 2018 admin 18 Jul, 2018 11:47 1.84 Mb 99
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