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Colon Cancer helped by modest Vitamin D (more needed) – July 2019

Can Vitamin D Supplementation Improve Progression-Free, Relapse-Free Survival in Gastrointestinal Cancers? Oncology Nurse Advisor

SUNSHINE Randomized Clinical Trial compared the effect of high-dose vs standard-dose vitamin D3 supplementation on progression-free survival (PFS) among patients with advanced or metastatic colorectal cancer

  • Lots of Chemotherapy
  • Started with 8,000 IU daily for 2 weeks then maintenance of 4,000 IU daily
  • 35 ng average at trial end
  • greater effect on survival if lower body mass index, more metastases, and KRAS wild-type tumors.
    • Needed more to get most people about 35 ng level, not just half
    • Also anticipate better survival if use larger loading dose ASAP
    • A typical loading dose protocol gives 400,000 IU in one week. This study used 112,000 IU in 2 weeks

AMATERASU Randomized Clinical Trial investigated the effect of vitamin D supplementation on relapse-free survival (RFS) among patients with digestive tract cancers.

  • stage I-III digestive tract epithelial carcinoma after surgical resection from the esophagus, stomach, small intestine, colon, or rectum.
  • 2,000 IU daily did not help, not a news item

Created by admin. Last Modification: Friday July 19, 2019 01:56:25 GMT-0000 by admin. (Version 6)
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