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Colon cancer risk reduced by many vitamins – 13 percent reduction by Vitamin D – meta-analysis Jan 2015

Vitamin and multiple-vitamin supplement intake and incidence of colorectal cancer: a meta-analysis of cohort studies.

Med Oncol. 2015 Jan;32(1):434. doi: 10.1007/s12032-014-0434-5. Epub 2014 Dec 10.
Liu Y1, Yu Q, Zhu Z, Zhang J, Chen M, Tang P, Li K.
1Department of Public Health, Shantou University Medical College, No. 22 Xinling Road, Shantou, 515041, Guangdong, China, huajianrui6666 at 126.com.

This paper systematically evaluated the association of intake of different vitamins and multiple-vitamin supplements and the incidence of colorectal cancer. Relevant studies were identified in MEDLINE via PubMed (published up to April 2014). We extracted data from articles on vitamins A, C, D, E, B9 (folate), B2, B3, B6, and B12 and multiple-vitamin supplements. We used multivariable-adjusted relative risks (RRs) and a random-effects model for analysis and random effects. With heterogeneity, we looked for the source of heterogeneity or performed sensitivity and stratified analyses. We found 47 articles meeting the inclusion criteria.
The multivariable-adjusted RR for pooled studies for the association between the highest versus lowest

  • vitamin B9 (folate) intake and colorectal cancer was 0.88 [95 % confidence interval (95 % CI) 0.81-0.95].
  • Vitamin D was 0.87 (95 % CI 0.77-0.99);
  • Vitamin B6, 0.88 (95 % CI 0.79-0.99);
  • vitamin B2, 0.86 (95 % CI, 0.76-0.97);
  • vitamin A, 0.87 (95 % CI, 0.75-1.03);
  • vitamin C, 0.92 (95 % CI, 0.80-1.06);
  • vitamin E, 0.94 (95 % CI, 0.82-1.07);
  • vitamin B12, 1.10 (95 % CI, 0.92-1.32);
  • vitamin B3, 1.18 (95 % CI, 0.76-1.84).

Vitamin B9 (folate), D, B6, and B2 intake was inversely associated with risk of colorectal cancer, but further study is needed. Our study featured unacceptable heterogeneity for studies of multiple-vitamin supplements, so findings were inconclusive.

PMID: 25491145

See also VitaminDWiki

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Overview of ColonCancer and vitamin D
Many meta-analysis of COLON Cancer and Vitamin D on VitaminDWiki: