Vitamin and multiple-vitamin supplement intake and incidence of colorectal cancer: a meta-analysis of cohort studies.
Med Oncol. 2015 Jan;32(1):434. doi: 10.1007/s12032-014-0434-5. Epub 2014 Dec 10.
Liu Y1, Yu Q, Zhu Z, Zhang J, Chen M, Tang P, Li K.
1Department of Public Health, Shantou University Medical College, No. 22 Xinling Road, Shantou, 515041, Guangdong, China, huajianrui6666 at 126.com.
This paper systematically evaluated the association of intake of different vitamins and multiple-vitamin supplements and the incidence of colorectal cancer. Relevant studies were identified in MEDLINE via PubMed (published up to April 2014). We extracted data from articles on vitamins A, C, D, E, B9 (folate), B2, B3, B6, and B12 and multiple-vitamin supplements. We used multivariable-adjusted relative risks (RRs) and a random-effects model for analysis and random effects. With heterogeneity, we looked for the source of heterogeneity or performed sensitivity and stratified analyses. We found 47 articles meeting the inclusion criteria.
The multivariable-adjusted RR for pooled studies for the association between the highest versus lowest
- vitamin B9 (folate) intake and colorectal cancer was 0.88 [95 % confidence interval (95 % CI) 0.81-0.95].
- Vitamin D was 0.87 (95 % CI 0.77-0.99);
- Vitamin B6, 0.88 (95 % CI 0.79-0.99);
- vitamin B2, 0.86 (95 % CI, 0.76-0.97);
- vitamin A, 0.87 (95 % CI, 0.75-1.03);
- vitamin C, 0.92 (95 % CI, 0.80-1.06);
- vitamin E, 0.94 (95 % CI, 0.82-1.07);
- vitamin B12, 1.10 (95 % CI, 0.92-1.32);
- vitamin B3, 1.18 (95 % CI, 0.76-1.84).
Vitamin B9 (folate), D, B6, and B2 intake was inversely associated with risk of colorectal cancer, but further study is needed. Our study featured unacceptable heterogeneity for studies of multiple-vitamin supplements, so findings were inconclusive.
- After 30 years it still appears that vitamin D deals with colorectal cancer – Oct 2012
- Colon cancer – how vitamin D prevents and treats it – Nov 2014
- Overview Cancer-Colon and vitamin D
which has the following chart - showing >> 13% benefit when have lots of vitamin D
Many meta-analysis of COLON Cancer and Vitamin D on VitaminDWiki:
- Colorectal cancer 25 percent less likely if good level of Vitamin D – 20th meta-analysis – June 2021
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Colorectal cancer treated by Vitamin D – 19th meta-analysis – Sept 2020
- Colon cancer both prevented and treated by Vitamin D – meta-analysis Dec 2019
- Colorectal cancer is associated with Vitamin D (17 meta-analyses so far) – July 2018
- Colorectal cancer 60 percent less likely: high vs low Vitamin D level – meta-analysis Dec 2016
- Colorectal Cancer recurrence not prevented by 1,000 IU of vitamin D – meta-analysis Dec 2016
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Colon cancer 30 percent more likely if low vitamin D – 12th meta-analysis Aug 2015
- Colon cancer risk reduced by many vitamins – 13 percent reduction by Vitamin D – meta-analysis Jan 2015
- Cancer (colon, breast, lymph) survival about 2X better with high level vitamin D – meta-analysis July 2014
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014
- 10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012
- Meta-graphs of vitamin D and Cancer – Dec 2011
- Colon cancer probability increases with decreased vitamin D – Meta-analysis July 2011
- Non-cancer colon growths 7 percent less likely with each 10 ng increase in vitamin D – Oct 2011
- Colorectal cancer 26 percent less likely for every 10 ng of vitamin D – meta-analysis Aug 2011
- Colon polyps reduced 15 percent by increasing vitamin D by 20 ng – meta-analysis June 2011
- Meta-analysis of 3 cancers - 10 ng more vitamin D decrease colorectal by 15 percent– May 2010
- Meta-analysis found vitamin D association with colon but not prostate nor breast cancer May 2010