World J Gastroenterol. 2015 Aug 7;21(29):8868-77. doi: 10.3748/wjg.v21.i29.8868.
Choi YJ1, Kim YH1, Cho CH1, Kim SH1, Lee JE1.
1Yoon Ji Choi, Young Ha Kim, Jung Eun Lee, Department of Food and Nutrition, Sookmyung Women's University, Seoul 140-742, South Korea.
To examine the association between circulating 25-hydroxyvitamin D [25(OH)D] levels and colorectal adenoma in a case-control study and a meta-analysis.
We conducted a matched case-control study (112 cases and 112 matched controls) and combined 15 studies, including our study, in a meta-analysis. The study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using a random-effects model. In total, 5454 colorectal adenomas and 6656 controls were included in the meta-analysis.
In a meta-analysis including 14 previous studies and our study, we observed a significant inverse association between circulating 25(OH)D levels and colorectal adenoma (OR = 0.68; 95%CI: 0.54-0.82) when comparing the highest category with the lowest category. Stratification by adenoma location (proximal or distal adenoma) showed similar estimates. When we stratified by study region, the ORs (95%CIs) were 0.70 (0.52-0.88) in the US and 0.66 (0.34-0.97) in Asia.
These data suggest an inverse association between circulating 25(OH)D levels and colorectal adenoma in both Western and Asian populations.
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