Review: the impacts of circulating 25-hydroxyvitamin D levels on cancer patient outcomes: a systematic review and meta-analysis.
J Clin Endocrinol Metab. 2014 Jul;99(7):2327-36. doi: 10.1210/jc.2013-4320. Epub 2014 Apr 29.
Li M1, Chen P, Li J, Chu R, Xie D, Wang H.
CONTEXT:
Circulating levels of 25-hydroxyvitamin D 25(OH)D may affect the prognosis of cancer patients; however, the epidemiological results are not consistent.
OBJECTIVE:
To perform a meta-analysis of all published studies to assess the associations of circulating 25(OH)D levels measured at or near the time of diagnosis and outcomes for cancer patients.
DATA SOURCES:
Searches of the PubMed and MEDLINE databases were performed and updated to December 2013.
STUDY SELECTION:
Studies reporting an association between circulating 25(OH)D levels at or near the time of diagnosis and outcomes for the patients were included.
DATA EXTRACTION:
Data extraction was performed independently by two authors, and conflicts were resolved by a third investigator.
DATA SYNTHESIS:
Included in the meta-analysis were 25 studies with 17 332 cases. Significant associations between circulating 25(OH)D levels at or near the time of diagnosis and the outcomes for cancer patients were found. The pooled hazard ratio for the highest vs the lowest quartile of circulating 25(OH)D levels was
- 0.55 (95% confidence interval [CI] = 0.33-0.91) for overall survival of colorectal cancer patients,
- 0.63 (95% CI = 0.51-0.77) for breast cancer patients, and
- 0.48 (95% CI = 0.36-0.64) for lymphoma patients.
Higher 25(OH)D levels were significantly associated with reduced cancer-specific mortality for patients with colorectal cancer (P = .005) and lymphoma (P < .001) and improved disease-free survival for patients with breast cancer (P < .001) or lymphoma (P < .05). A 10-nmol/L increment in circulating 25(OH)D levels conferred a hazard ratio of 0.96 (95% CI = 0.95-0.97) for overall survival of the cancer patients.
CONCLUSIONS:
The results indicate that cancer patients with higher circulating 25(OH)D levels at or near the time of diagnosis have better outcomes.
PMID: 24780061
See also VitaminDWiki
The Meta-analysis of many studies of BREAST Cancer and Vitamin D are listed here:
- Analysis of 280 Breast Cancer meta-analyses: having low vitamin D was highly suggestive – umbrella July 2024
- Breast Cancer not prevented by vitamin D when use small doses or for just a short time – Meta-analysis April 2023
- Breast Cancer risk - meta-analysis of 50 studies - Dec 2019
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020
- Breast Cancer risk reduced 17 percent by 1 hour of daily summer sun – meta-analysis Jan 2020
- Breast Cancer reduced 20 percent by fish (Omega-3) – meta-analysis Feb 2019
- Breast Cancer rate reduced by 40 percent with Omega-3 – meta-analysis June 2013
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
- Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015
- Cancer (colon, breast, lymph) survival about 2X better with high level vitamin D – meta-analysis July 2014
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014
- More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014
- Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014
- Breast Cancer – review of 2 RCT did not find association with 1000 IU of Vitamin D – July 2013
- Breast Cancer post menopause down 12 percent for every 5 ng of vitamin D – meta-analysis May 2013
- 3.2 percent less Breast Cancer for 2.4 ng more vitamin D – meta-analysis June 2013
- Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013
- Meta-graphs of vitamin D and Cancer – Dec 2011
- Meta-analysis not find low vitamin D years before breast cancer – Aug 2010
- Meta-analysis confirmed that vitamin D and calcium prevents breast cancer – June 2010
- Meta-analysis found vitamin D association with colon but not prostate nor breast cancer May 2010
- Breast cancer association with low vitamin D suggested by Meta-analysis -April 2010
- Meta-analysis did not find strong association between vitamin D and breast cancer risk -April 2010
The Meta-analysis of many studies of COLON Cancer and Vitamin D are listed here:
- 16 factors increase the risk of early-onset colorectal cancer, only vitamin D decreases the risk – meta-analysis May 2023
- Colorectal Cancer 10 percent more likely if poor Vitamin D Receptor – meta-analysis Jan 2023
- Colorectal cancer 14 percent less likely if 10 ng more Vitamin D – 22nd meta-analysis – Sept 2022
- Colorectal cancer 40 percent less likely if 1000 IU more Vitamin D – 21st meta-analysis – Oct 2021
- Colorectal cancer 25 percent less likely if good level of Vitamin D – 20th meta-analysis – June 2021
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Colorectal cancer treated by Vitamin D – 19th meta-analysis – Sept 2020
- Colon cancer both prevented and treated by Vitamin D – meta-analysis Dec 2019
- Colorectal cancer is associated with Vitamin D (17 meta-analyses so far) – July 2018
- Colorectal cancer 60 percent less likely: high vs low Vitamin D level – meta-analysis Dec 2016
- Colorectal Cancer recurrence not prevented by 1,000 IU of vitamin D – meta-analysis Dec 2016
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Colon cancer 30 percent more likely if low vitamin D – 12th meta-analysis Aug 2015
- Colon cancer risk reduced by many vitamins – 13 percent reduction by Vitamin D – meta-analysis Jan 2015
- Cancer (colon, breast, lymph) survival about 2X better with high level vitamin D – meta-analysis July 2014
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014
- 10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012
- Meta-graphs of vitamin D and Cancer – Dec 2011
- Colon cancer probability increases with decreased vitamin D – Meta-analysis July 2011
- Non-cancer colon growths 7 percent less likely with each 10 ng increase in vitamin D – Oct 2011
- Colorectal cancer 26 percent less likely for every 10 ng of vitamin D – meta-analysis Aug 2011
- Colon polyps reduced 15 percent by increasing vitamin D by 20 ng – meta-analysis June 2011
- Meta-analysis of 3 cancers - 10 ng more vitamin D decrease colorectal by 15 percent– May 2010
- Meta-analysis found vitamin D association with colon but not prostate nor breast cancer May 2010