Analysis of 280 Breast Cancer meta-analyses: having low vitamin D was highly suggestive – umbrella July 2024

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Non-genetic factors and breast cancer: an umbrella review of meta-analyses

BMC Cancer. 2024 Jul 26;24(1):903. doi: 10.1186/s12885-024-12641-8.
Anneza Yiallourou 1, Katerina Pantavou 1, Georgios Markozannes 2 3, Antonis Pilavas 1, Andrea Georgiou 1, Andria Hadjikou 1, Mary Economou 1, Neophytos Christodoulou 4, Konstantinos Letsos 1, Elina Khattab 1, Chrystalleni Kossyva 1, Maria Constantinou 1, Melanie Theodoridou 1, Daniele Piovani 5 6, Konstantinos Κ Tsilidis 2 3, Stefanos Bonovas 5 6, Georgios K Nikolopoulos 7

Background: Previous research has found associations between various non-genetic factors and breast cancer (BrCa) risk. This study summarises and appraises the credibility of the available evidence on the association between non-genetic factors and BrCa risk.

Methods: We conducted an umbrella review of meta-analyses. Medline, Scopus, and the Cochrane databases were systematically searched for meta-analyses examining non-genetic factors and BrCa incidence or mortality. The strength of the evidence was graded in four categories (i.e., weak, suggestive, highly suggestive, convincing).

Results: A total of 781 meta-analyses from 280 publications were evaluated and graded. We included exposures related to anthropometric measurements, biomarkers, breast characteristics and diseases, diet and supplements, environment, exogenous hormones, lifestyle and social factors, medical history, medication, reproductive history, and pregnancy. The largest number of examined associations was found for the category of diet and supplements and for exposures such as aspirin use and active smoking. The statistically significant (P-value < 0.05) meta-analyses were 382 (49%), of which 204 (53.4%) reported factors associated with increased BrCa risk.
Most of the statistically significant evidence (n = 224, 58.6%) was graded as weak.
Convincing harmful associations with heightened BrCa risk were found for

• increased body mass index (BMI),
• BMI and weight gain in postmenopausal women,
• oral contraceptive use in premenopausal women,
• increased androstenedione, estradiol, estrone, and testosterone concentrations,
• high Breast Imaging Reporting and Data System (BIRADS) classification, and
• increased breast density.

Convincing protective factors associated with lower BrCa risk included high fiber intake and high sex hormone binding globulin (SHBG) levels while highly suggestive protective factors included high 25 hydroxy vitamin D [25(OH)D] levels, adherence to healthy lifestyle, and moderate-vigorous physical activity.

Conclusions: Our findings suggest some highly modifiable factors that protect from BrCa. Interestingly, while diet was the most studied exposure category, the related associations failed to reach higher levels of evidence, indicating the methodological limitations in the field. To improve the validity of these associations, future research should utilise more robust study designs and better exposure assessment techniques. Overall, our study provides knowledge that supports the development of evidence-based BrCa prevention recommendations and guidance, both at an individual level and for public health initiatives.
 Download the PDF from VitaminDWiki
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Highly convincing vitamin D data as from:
Song D, Deng Y, Liu K, Zhou L, Li N, Zheng Y, et al. Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose response meta-analysis of observational studies. Aging (Albany NY).2019;11:12708–32. in VitaminDWiki
Breast Cancer risk - meta-analysis of 50 studies - Dec 2019 which has:

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VitaminDWiki - 25 Breast Cancer meta-analyses

This list is automatically updated

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VitaminDWiki – Overview Breast Cancer and Vitamin D contains:

• 25 Meta-analyses of Vitamin D and Breast Cancer
    example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D.
• Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
     wonder just how much more proof is needed
• Breast Cancer 4X more likely if have poor genes
•     Cancer - Breast category listing has 262 items along with related searches
• Breast Cancer treatment – Vitamin D was the most-popular supplement – Jan 2023
• Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020
• Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019
• Vitamin D both prevents and treats Breast Cancer – 2019

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