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COVID-19 patients are deficient in both Vitamin D and Vitamin K – Oct 2021

Vitamin K & D Deficiencies Are Independently Associated With COVID-19 Disease Severity

Open Forum Infect Dis. 2021 Jul 29;8(10):ofab408. doi: 10.1093/ofid/ofab408. eCollection 2021 Oct.
Ankita P Desai 1 2 3, Sahera Dirajlal-Fargo 1 2 3, Jared C Durieux 1, Heather Tribout 1, Danielle Labbato 1, Grace A McComsey 1 2 3

Background: We investigated the association of vitamin K and vitamin D with coronavirus disease 2019 (COVID-19) outcomes.

Methods: Levels of inactive vitamin K-dependent dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP; marker of vitamin K status) and 25-hydroxyvitamin D (25(OH)D; vitamin D status) were measured in plasma samples from participants with confirmed acute COVID-19 and were age- and sex-matched to healthy controls. Unadjusted odds ratios and adjusted odds ratios (AORs) with 95% CIs were computed using cumulative logistic regression.

Results: One hundred fifty subjects were included, 100 COVID-19+ and 50 controls. The median age (interquartile range) was 55 (48-63) years, and 50% were females. Thirty-four percent had mild COVID-19 disease, 51% moderate disease, and 15% severe. Dp-ucMGP levels were higher (ie, worse K status) in COVID-19+ vs controls (776.5 ng/mL vs 549.8 ng/mL; P < .0001) with similar 25(OH)D between groups (25.8 vs 21.9 ng/mL; P = .09). Participants who were vitamin D deficient (<20 ng/mL) had the worse vitamin K status (dp-ucMGP >780 ng/mL) and experienced the most severe COVID-19 outcomes. In adjusted models, every 1-unit increase in the log2 dp-ucMGP nearly doubled the odds of acute critical disease or death (AOR, 1.84; 95% CI, 1.01-3.45), and every 1-unit decrease in the natural log 25(OH)D was associated with >3 times the likelihood of severe COVID-19 disease (AOR, 0.29; 95% CI, 0.11-0.67).

Conclusions: Early in acute COVID-19, both vitamin K and vitamin D deficiency were independently associated with worse COVID-19 disease severity, suggesting a potential synergistic interplay between these 2 vitamins in COVID-19.
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Worse COVID-19 if Low K, independent of low or high D

3 Clinical Trials of Vitamin K and COVID-19 as of Oct 2021

1 Canadian trial is using Vitamin D + Vitamin K


COVID-19 treated by Vitamin D - studies, reports, videos

5 most-recently changed Virus entries

Items in both categories Vitamin K and Virus:
Overview Vitamin K and Vitamin D contains the following summary

Vitamin K2 is similar to D3 in many ways

  1. Both vitamins were initially confused with its lesser form (D2 ==> D3, K1 ==> K2)
  2. Both vitamins appear to influence health in large number of ways
  3. Both vitamins in the body are about 1/10 that of a century ago
    Example: Grass-fed beef has a lot more K2, D3, and Magnesium
  4. Need very little of both vitamins: <1 milligram daily
  5. When Vitamin D3 is increased, it appears that Vitamin K2 should also be increased
  6. Vitamin K2 understanding and research is about 20 years behind that of Vitamin D3
    One of the reasons: No simple blood test for K2 as of Jan 2020
items in BOTH the categories Vitamin K and Cardiovascular

Created by admin. Last Modification: Thursday October 14, 2021 12:09:20 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
16407 LowK is high or low vitamin D and COVID.jpg admin 14 Oct, 2021 60.45 Kb 256
16405 Vitamin K & D Deficiencies indep with COVID-19.pdf admin 14 Oct, 2021 466.88 Kb 260