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600,000 IU of vitamin D – 42 ng at 3 months for 1 inj, 3 inj, oral monthly, oral weekly - Oct 2017

Comparison Of Different Formulations Of Vitamin D.

J Ayub Med Coll Abbottabad. 2017 Oct-Dec;29(4):650-653.
Fahan Rashid HM1, Syed U1, Ahmad Z2, Chauhdary KK3, Musharraf U3, Kumar S3.


600,000 IU ==> 42 ng/ml in 3 months

FormDose Frequency
Injection 600,000 IU once
Injection 200,000 IU3 times
Oral200,000 IU 3 times
Oral50,000 IU12 times

Poor Gut

Emergencies - fast response required

Overview Loading of vitamin D contains the following

If a person is, or is suspected to be, very vitamin D deficient a loading dose is typically given

  • Loading = repletion = quick replacement (previously known as Stoss)
  • Loading doses range in size from 100,000 IU to 1,000,000 IU of Vitamin D3
  • The size of the loading dose is a function of body weight - see below
    Unfortunately, some doctors persist in using Vitamin D2 instead of D3
  • Loading may be done as quickly as a single day, to as slowly as 3 months.
    It appears that spreading the loading dose over 4-20 days is a good compromise
  • Loading is typically oral, but sometimes by injection (I.M,)
  • The loading dose persists in the body for about 3 months
    The loading dose should be followed up with continuing maintenance
    Unfortunately, many doctors fail to follow-up with the maintenance dosing.
  • As about 1 in 300 people have some form of mild allergic reaction to vitamin D supplements,
    it appears prudent to test with a small amount of vitamin D before giving a loading dose
  • The causes of a mild allergic reaction appear to be: (in order of occurance)
    1) lack of magnesium - which can be easily added
    2) allergy to capsule contents - oil, additives (powder does not appear to cause any reaction)
    3) allergy to the tiny amount of D3 itself (allergy to wool) ( alternate: D3 made from plants )
Loading dose: 133 studies at VitaminDWiki

 Download the PDF from VitaminDWiki

Vitamin D Deficiency (VDD) is responsible for a wide spectrum of clinical diseases and vitamin D deficiency prevalence is frightening in most parts of the world including Pakistan. Therefore, supplementations of vitamin D are used in the population at high risk for the prevention and the treatment of vitamin D deficiency. Vitamin D supplementation comes in various formulations both oral and intramuscular. Cholecalciferol is the most commonly used preparation which is given through these routes of administration. There is need to study the fact that how much vitamin D levels are raised after administration of these different formulations as this can be a pivotal factor in determining dosage and route of vitamin D3.

This cross-sectional study conducted on 320 cases and compared the efficacy of various Vitamin D3 preparations in raising Vitamin D levels conducted in Department of Endocrinology and Metabolism, Services Hospital, Lahore from February to July, 2016. Blood serum was drawn for vitamin D level in the cases at the time of presentation and after treatment.

Three hundred & twenty patients were enrolled in study and divided into four groups (A, B, C, D). There was no significant difference between groups (A, B, C, D) in change in vitamin d levels after 3 months of treatment (p-Value 0.446).

Different preparations of vitamin D are equally effective in raising vitamin D levels at 12 weeks. However, there is a need to conduct large scale studies to further validate these results.

PMID: 29330997

Created by admin. Last Modification: Monday January 15, 2018 03:17:17 GMT-0000 by admin. (Version 7)

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9185 Comparison Of Different Formulations Of Vitamin D.pdf PDF 2017 admin 15 Jan, 2018 02:33 151.32 Kb 532
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