Low Serum Levels of 25-Hydroxyvitamin D Are Associated with Stroke Recurrence and Poor Functional Outcomes in Patients with Ischemic Stroke.
J Nutr Health Aging. 2017;21(8):892-896. doi: 10.1007/s12603-016-0846-3.
Ji W1, Zhou H, Wang S, Cheng L, Fang Y.
1) Vitamin D prevents strokes
2) Vitamin D can treat a stroke (injection or loading dose)
3) High vitamin D results in better stroke outcome
- Overview Stroke and vitamin D
- Vitamin D associated with 50 percent less ischemic stroke – meta-analysis Aug 2012
- Twice as many fatal strokes among whites who were low on vitamin D – Jan 2012
- Stroke mortality 3X worse among seniors with less than 26 ng of vitamin D – June 2014
- Stroke is 13.5 X more likely if low vitamin D and high blood pressure – March 2015
- Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015
- Death within 2 years of surviving an ischemic stroke 10X less likely if high vitamin D – July 2017
- Stroke 74% less likely if high vitamin D (7,295 women 20-50 years old) – July 2017
- Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017
To evaluate the association between serum 25(OH) D levels and functional outcome and stroke recurrence events in a 6-month follow-up study in a cohort of patients with an acute ischemic stroke (AIS).
From March 2014 to August 2015, consecutive first-ever AIS patients admitted to the Department of Emergency of our hospital were identified. Serum 25(OH) D levels were measured at admission. Functional outcome was evaluated at 6-month using the modified Rankin scale (m-Rankin). We used logistic regression models to assess the relationship between 25(OH) levels and risk of recurrent stroke or functional outcome.
We recorded 277 stroke patients. There were significantly negative correlation between levels of 25(OH) D and NHISS (P<0.001), and the infarct volume (P< 0.001). Thirty-one patients (11.9%) had a stroke recurrence, while 82 patients (29.6) were with poor functional outcomes.
In multivariate logistic regression analyses, serum 25(OH) D level was an independent marker of poor functional outcome and stroke recurrence [odds ratio (OR) 2.55 (1.38-3.96) and 3.03(1.65-4.12), respectively, P<0.001 for both, adjusted for NHISS, other predictors and vascular risk factors] in patients with AIS.
Our results demonstrate that low 25(OH) D levels are associated with stroke recurrence and support the hypothesis that 25(OH) D may serve as a biomarker of poor functional outcome after stroke.
PMID: 28972241 DOI: 10.1007/s12603-016-0846-3