Low Serum Levels of 25-Hydroxyvitamin D Are Associated with Stroke Recurrence and Poor Functional Outcomes in Patients with Ischemic Stroke.
J Nutr Health Aging. 2017;21(8):892-896. doi: 10.1007/s12603-016-0846-3.
Ji W1, Zhou H, Wang S, Cheng L, Fang Y.
1) Vitamin D prevents strokes
2) Vitamin D can treat a stroke (injection or loading dose)
3) High vitamin D results in better stroke outcome
- Overview Stroke and vitamin D
- Vitamin D associated with 50 percent less ischemic stroke – meta-analysis Aug 2012
- Twice as many fatal strokes among whites who were low on vitamin D – Jan 2012
- Stroke mortality 3X worse among seniors with less than 26 ng of vitamin D – June 2014
- Stroke is 13.5 X more likely if low vitamin D and high blood pressure – March 2015
- Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015
- Death within 2 years of surviving an ischemic stroke 10X less likely if high vitamin D – July 2017
- Stroke 74% less likely if high vitamin D (7,295 women 20-50 years old) – July 2017
- Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017
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OBJECTIVE:
To evaluate the association between serum 25(OH) D levels and functional outcome and stroke recurrence events in a 6-month follow-up study in a cohort of patients with an acute ischemic stroke (AIS).
METHODS:
From March 2014 to August 2015, consecutive first-ever AIS patients admitted to the Department of Emergency of our hospital were identified. Serum 25(OH) D levels were measured at admission. Functional outcome was evaluated at 6-month using the modified Rankin scale (m-Rankin). We used logistic regression models to assess the relationship between 25(OH) levels and risk of recurrent stroke or functional outcome.
RESULTS:
We recorded 277 stroke patients. There were significantly negative correlation between levels of 25(OH) D and NHISS (P<0.001), and the infarct volume (P< 0.001). Thirty-one patients (11.9%) had a stroke recurrence, while 82 patients (29.6) were with poor functional outcomes.
In multivariate logistic regression analyses, serum 25(OH) D level was an independent marker of poor functional outcome and stroke recurrence [odds ratio (OR) 2.55 (1.38-3.96) and 3.03(1.65-4.12), respectively, P<0.001 for both, adjusted for NHISS, other predictors and vascular risk factors] in patients with AIS.
CONCLUSION:
Our results demonstrate that low 25(OH) D levels are associated with stroke recurrence and support the hypothesis that 25(OH) D may serve as a biomarker of poor functional outcome after stroke.
PMID: 28972241 DOI: 10.1007/s12603-016-0846-3