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Orthopaedic surgeries need Vitamin D – many studies


Orthopedic Surgery can often be eliminated by increasing Vitamin D levels

Items in both categories Osteoporsis and Intervention are listed here:

Items in both categories Osteoporsis and Surgery are listed here:

Items in both categories Bone and Surgery are listed here:

Osteoarthritis category includes the following

52 items total - see also Overview Osteoporosis and vitamin D

Overview Osteoarthritis and Vitamin D
Search VitaminDWiki for CARTILAGE 393 items as of July 2018
See also Ankylosing spondylitis
Search VitaminDWiki for "Knee Osteoarthritis" 410 items as of Oct 2020

Infections after bone surgery are associated with low vitamin D - Review Sept 2021

The role of Vitamin D in orthopaedic infection: a systematic literature review
Bone Jt Open . 2021 Sep;2(9):721-727. doi: 10.1302/2633-1462.29.BJO-2020-0192.R1.
Alexander Zargaran 1 2, David Zargaran 3, Alex J Trompeter 4

Aims: Orthopaedic infection is a potentially serious complication of elective and emergency trauma and orthopaedic procedures, with a high associated burden of morbidity and cost. Optimization of vitamin D levels has been postulated to be beneficial in the prevention of orthopaedic infection. This study explores the role of vitamin D in orthopaedic infection through a systematic review of available evidence.

Methods: A comprehensive search was conducted on databases including Medline and Embase, as well as grey literature such as Google Scholar and The World Health Organization Database. Pooled analysis with weighted means was undertaken.

Results: Pooled analysis of four studies including 651 patients found the mean 25(OH)D level to be 50.7 nmol/l with a mean incidence of infection of 70%. There was a paucity of literature exploring prophylactic 25(OH)D supplementation on reducing orthopaedic infection, however, there was evidence of association between low 25(OH)D levels and increased incidence of orthopaedic infection.

Conclusion: The results indicate a significant proportion of orthopaedic patients have low 25(OH]D levels, as well as an association between low 25(OH)D levels and orthopaedic infection, but more randomized controlled trials need to be conducted to establish the benefit of prophylactic supplementation and the optimum regimen by dose and time

Clipped from PDF
Haines et al 11 completed a randomized double-blind placebo-controlled trial of 113 adults with long-bone fractures, where patients in the intervention group were given a single dose of 100,000 IU of vitamin D orally within two weeks of their injury found that
infection occurred in

  • 2% of the control group (n = 1/50) and
  • none of the intervention group.

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Current concepts in vitamin D and orthopaedic surgery - April 2019

Orthopaedics & Traumatology: Surgery & Research https://doi.org/10.1016/j.otsr.2018.12.006 1877-0568/
Andrews. Moona’b, Sellers Boudreaub, Eric Mussellb,Jun KitHeb’, Eugene W. Brabstonb, Brent A. Ponceb, Amit M. Momayab
a Tufts University School of Medicine, Boston, MA, USA
b Department of Orthopaedics, The University of Alabama at Birmingham, 951 18th St. S, 35205 Birmingham, AL, USA

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Introduction: Vitamin D plays an important role in the musculoskeletal system of the human body. Here, we review the most current literature on vitamin D as it relates to orthopaedic surgery and the musculoskeletal system, focusing largely on non-fracture applications.

Materials and methods: A literature review was performed on the basic science of vitamin D metabolism, epidemiology of vitamin D levels, role of vitamin D within the musculoskeletal system, and the correlation of vitamin D with injuries and orthopaedic surgical outcomes.

Results: The existing literature suggests vitamin D plays multiple roles in the musculoskeletal system. Recent research has shed light on the importance of vitamin D in the setting of soft tissue healing and recovery in addition to affecting postoperative outcomes after common orthopaedic procedures.
Conclusions: Given the widespread prevalence of vitamin D deficiency, orthopaedic surgeons should be aware of the current evidence regarding clinical implications in patients with musculoskeletal complaints.

Table 1: Vitamin D and orthopaedic procedures.
ACL reconstruction Lowvitamin D levels (<30 ng/mL) may delay muscle strength recovery after ACL reconstruction [42]
Decreased articular damage & inflammatory mediators in rats given intra-articular vitaminD injections post- in vivo ACL transections [9]
Rotator cuff Low vitamin D levels may negatively affect early healing of rotator cuff repair sites in rats [43]
Low vitamin D levels (<30 ng/mL) associated with fatty degeneration of rotator cuff[44] Vitamin D levels positively correlated with isokinetic muscle torque of the shoulder [44]
Clinically, low vitamin D levels showed no correlation with outcomes (UCLA, CS, ASES) following rotator cuff repair [45]
Arthroplasty Low vitamin D levels may result in longer hospital stays following TJA [65]
High prevalence of low vitamin D levels in TJA patients [66]
Low vitamin D levels (<20 ng/mL) associated with increased risk of postoperative complications, including periprosthetic joint infection [66,67]
Knee arthroplasty Vitamin D deficient (<12ng/mL) patients undergoing TKA have significantly worse outcomes (KSS, alternative step-test, six-meter walk test) [57-60]
Vitamin D deficient mice with intra-articular knee implants have increased bacterial burden and increased neutrophil infiltration in knee joint, reversible with vitamin D3 supplementation [68]
Hip arthroplasty Lower pre- & postoperative Harris hip scores in vitamin D deficient THA patients [62]
No association between vitamin D levels in THA patients & short-term postoperative outcomes (in-hospital milestones, length of stay, perioperative complications, WOMAC,SF-36, 2-minute walk test, & timed get up-and-gotests) [63,64]
Shoulder arthroplasty High prevalence of low vitamin D levels in shoulder arthroplasty patients [29]

UCLA: University of California, Los Angeles; CS: Constant score; ASES: American Shoulderand ElbowSociety; KSS: American Knee SocietyScore; WOMAC: Western Ontario and McMasterUniversities Osteoarthritis Index; SF-36: Short-Form-36; TJA: totaljoint arthroplasty; TKA: total knee arthroplasty; THA: total hip arthroplasty.

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Attached files

ID Name Comment Uploaded Size Downloads
16187 orthopaedic infection review.pdf PDF 2021 admin 07 Sep, 2021 12:56 473.92 Kb 4
11767 vitamin D and orthopaedic.pdf admin 14 Apr, 2019 19:00 888.83 Kb 430
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