TBI reduced 5X by 300,000 IU of vitamin D (injection) – RCT Oct 2024

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Investigating the Effect of High-Dose Vitamin D3 Administration on Inflammatory Biomarkers in Patients with Moderate to Severe Traumatic Brain Injury: A Randomized Clinical Trial

FIran J Med Sci. 2024 Oct 1;49(10):643-651. doi: 10.30476/ijms.2023.99465.3156
arnoosh Masbough 1, Mehran Kouchek 2, Mohsen Koosha 3, Sara Salarian 2, Mirmohammad Miri 2, Masoomeh Raoufi 4, Niloufar Taherpour 5, Saied Amniati 6, Mohammad Sistanizad 1 7

Background: Traumatic brain injury (TBI) is one of the most common neurological disorders worldwide. We aimed to investigate the efficacy of high-dose vitamin D3 on inflammatory biomarkers in patients with moderate to severe TBI.

Methods: Thirty-five moderate to severe TBI patients were randomly assigned to intervention and control groups. Patients in the intervention group received a single intramuscular (IM) dose of 300,000 IU vitamin D. The primary endpoints were interleukin levels (IL-1β and IL-6), and the secondary endpoints were changes in neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), Glasgow Coma scale (GCS), and Glasgow Outcome Scale-Extended (GOS-E) scores compared between intervention and control arms of the study. The linear Generalized Estimating Equations were used for trend analysis and evaluating the association of independent factors to each outcome.

Results: The results revealed a significant decrease in IL-1β levels (-2.71±3.02, in the intervention group: P=0.001 vs. -0.14±3.70, in the control group: P=0.876) and IL-6 (-88.05±148.45, in the intervention group: P=0.0001 vs. -35.54±175.79, in the control group L P=0.325) 3 days after the intervention. The improvement in the GCS score (P=0.001), reduction in NLR (P=0.001) and PLR (P=0.002), and improvement in the GOS-E score (P=0.039) was found to be greater in the vitamin D3 arm of the study than the control group.

Conclusion: Administration of high-dose vitamin D3 in the acute phase of TBI could be effective in lowering the inflammatory markers and improving the level of consciousness and long-term performance outcomes.
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5X more likely to be alert 3 months later

• Patients in the vitamin D3 group were found to improve on the GOS-E scale 3 months after discharge, roughly five times more likely than the control group, according to the results in table 3 after adjusting for the effects of confounding variables. (OR=5.38, 95% CI=1.08-26.71, P=0.039)

No deaths in group getting the vitamin D vs 12 in control group

"There was no statistically significance difference in 28-day mortality rate (0% vs. 12.5%, P=0.202),..."

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VitaminDWiki - Traumatic Brain Injury treated by Vitamin D - many studies

Contains

• 40% less likely to recover from TBI with Intracranial Injury if low vitamin D – June 2022
• Traumatic Brain Injury recovered faster if high vitamin D (review of 58 studies) – April 2021

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VitaminDWiki - Result of 5 years of Vitamin D given to athletes in a high school: $60 million in scholarships, almost zero concussions, etc. - June 2016

5 concussions annually before vitamin D - perhaps Vitamin D PREVENTS consussions

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VitaminDWiki – Injection - few reasons to have the treatment that is far more expensive

64 items in Vitamin D Injection category

• Vitamin D injections last longer (3 month vs 2 month) than loading doses
• Getting Vitamin D into your body shows the many ways of getting Vitamin D

• Injections are currently made by medical professionals into muscle
• Home injection of Vitamin D appears to be possible in the future
• Injections are useful for people who might forget to take their periodic supplement (children, elderly, etc) and those who cannot swallow or have poor digestion
• While Vitamin D2 is historically the common form, Vitamin D3 is far better
• Should check (if there is time) for possible allergic reaction to Vitamin D or lack of Magnesium for both for loading dose and injection
• Note 600,000 IU Vitamin D loading dose via capsules is 1/20th the cost($2.40) of an injection, and does not require a prescription
• 100,000 IU single dose of vitamin D - 2010 has the following
  
• Vitamin D injection lasts longer and has bigger response than weekly oral – Jan 2017 has the following
  
• Non-oral Vitamin D should be a better form for MS, food allergy, PTSD, etc. – many studies might include injection