Loading...
 
Translate Register Log In Login with facebookLogin and Register

Traumatic Brain Injury – 120,000 IU of Vitamin D resulted in 3 fewer days on ventilators – RCT March 2020

Neuroprotective Role of Oral Vitamin D Supplementation on Consciousness and Inflammatory Biomarkers in Determining Severity Outcome in Acute Traumatic Brain Injury Patients: A Double-Blind Randomized Clinical Trial

Clin Drug Investig, 2020 Mar 14 DOI: 10.1007/s40261-020-00896-5
Swapnil Sharma 1, Ashok Kumar 1, Ajay Choudhary 2, Shallu Sharma 1, Lipika Khurana 3, Neera Sharma 4, Vijender Kumar 4, Akansha Bisht 1

VitaminDWiki

Trauma and surgery category starts with the following

Trauma and Surgery category has 269 articles

see also Concussions
Overview Fractures and Falls and Vitamin D
Cancer - After diagnosis   chemotherapy
Search VitaminDWiki for TBI OR "Traumatic Brain Injury" 798 items as of March 2020
Search VitaminDWiki for cathelecidin OR hCAP18 219 items as of March 2020
Search VitaminDWiki for ICU OR “critical care” OR “intensive care” OR “acute care”
   1740 items as of May 2019

Search VitaminDWiki for transplant 794 items as of Jan 2018


The items which are in both Intervention and Trauma/Surgery are listed here


Pages in BOTH of the categories: Trauma/Surgery and Loading Dose


Background and objective: Early management of traumatic brain injury (TBI) is essential. We aimed to evaluate the efficacy of vitamin D over early clinical outcome and serum cytokine levels in patients with moderate to severe brain injury.

Methods: Thirty-five patients with moderate to severe traumatic brain injury who were admitted to the ICU unit were recruited into the study. Subjects were randomly allocated to a treatment regimen comprising either a one-time oral dose of 120,000 IU (two tablets of 60,000 IU each) of vitamin D (n = 20) or 8 mg of saccharide (two tablets of 4 g each) as placebo (n = 15). The main parameters evaluated included duration of mechanical ventilation and ICU stay, Glasgow Coma Scale (GCS) and cytokine levels (interleukin (IL)-6, tumour necrosis factor (TNF)-α, interferon (IFN)-γ, IL-2).

Results: The results indicated an improvement in the level of consciousness after 7 days in the vitamin D-treated group compared with placebo. An elevation in GCS score by 3.86 units in the vitamin D-treated group with a 0.19-unit descent in the control group was recorded. Duration of mechanical ventilation was reduced in the vitamin D-treated group compared with the control group (4.7 days vs. 8.2 days, p value 0.0001). A noticeable reduction was recorded in inflammatory biomarkers (cytokines) in the vitamin D-treated group (IL-6 p = 0.08, TNF-α p = 0.02, IL-2 p = 0.36) with notable elevation in IFN-γ (p = 0.65) compared to the control group.

Conclusion: In the acute phase of moderate to severe traumatic brain injury, vitamin D supplementation plays a vital role and has a favourable effect on the consciousness level of patients. Clinical trial Registry (CTRI) No. CTRI/2019/05/019259.

Created by admin. Last Modification: Tuesday March 17, 2020 12:48:46 GMT-0000 by admin. (Version 2)
See any problem with this page? Report it (FINALLY WORKS)