Vitamin D Deficiency and Prognosis after Traumatic Brain Injury with Intracranial Injury: A Multicenter Observational Study
J Neurotrauma. 2022 Jun 9. doi: 10.1089/neu.2022.0053
Eujene Jung 1, Young Sun Ro 2, Jeong Ho Park 3, Sung Bae Moon 4, Stephen Gyung Won Lee 5, Gwan Jin Park 6, Hyun Ho Ryu 7, Sang Do Shin 8
Vitamin D may be important for neuroprotection after traumatic brain injury (TBI) by modifying the inflammatory response. The objective of this study was to evaluate the association between vitamin D deficiency and functional and survival outcomes in patients with TBI and intracranial injury. This study was a prospective multicenter cohort study conducted on adult TBI patients, with intracranial hemorrhage or diffuse axonal injury confirmed by radiological examination, admitted to five participating emergency departments (EDs) from December 2018 to June 2020. The study outcomes were good functional recovery at hospital discharge and survival at 6-months after injury. The primary exposure was serum vitamin D deficiency (0-10 ng/ml). Multilevel logistic regression analysis was performed to estimate the association between vitamin D deficiency and the study outcomes. Among 606 patients, 101 (16.7%) patients had vitamin D deficiency at the time of ED arrival.
Good functional recovery was observed in 65.2% (395/606) of total population, and this proportion was significantly lower in the vitamin D deficiency group than the non-deficiency group (56.4 vs. 66.9%, p=0.04, adjusted OR (95% CI): 0.56 (0.36-0.88)).
Overall survival rate at 6-months after injury was 79.5% (434/546), and patients with vitamin D deficiency had significantly lower likelihood of survival at 6-months than patients without deficiency (75.0 vs. 80.3%, adjusted OR (95% CI): 0.59 (0.39-0.89)).
Vitamin D deficiency is associated with poor functional outcomes at hospital discharge and mortality at 6-months after injury in TBI patients with intracranial hemorrhage or diffuse axonal injury. .
VitaminDWiki items with "Traumatic Brain Injury" or "TBI" in the title (19 as of June 2022)
Items found: 21
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How Vitamin D treats Traumatic Brain Injury – July 2022 |
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26 Jan, 2023 |
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40% less likely to recover from TBI with Intracranial Injury if low vitamin D – June 2022 |
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09 Jun, 2022 |
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Traumatic Brain Injury recovered faster if high vitamin D (review of 58 studies) – April 2021 |
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09 Jun, 2022 |
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Vitamin D3 Attenuates Blood-Brain Barrier Disruption due to TBI (in rats) – Feb 2021 |
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23 Feb, 2021 |
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Traumatic Brain Injury – 120,000 IU of Vitamin D resulted in 3 fewer days on ventilators – RCT March 2020 |
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17 Mar, 2020 |
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Traumatic Brain Injuries treated by Vitamin D etc (US patent) – interview Dec 2019 |
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25 Dec, 2019 |
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Preventing and treating TBI with Vitamin D, Magnesium Omega-3, Zinc, etc – book 2011 |
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21 May, 2019 |
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Vitamin B12 treats Traumatic Brain Injury in mice – April 2019 |
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21 May, 2019 |
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Traumatic Brain Injuries routinely treated by Vitamin D, Omega-3, Progesterone and Gluatmine |
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15 May, 2019 |
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Traumatic Brain Injury recovery helped by injection of 100,000 IU of Vitamin D – March 2019 |
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13 May, 2019 |
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Spinal cord problems more likely if TBI if little Omega-3 in diet – June 2013 |
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07 Oct, 2018 |
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Dementia risk increased 2.4 X following TBI, even if had not lost consciousness – May 2018 |
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12 May, 2018 |
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5 Traumatic brain injuries resulted in 2.8 X increased risk of dementia – April 2018 |
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11 Apr, 2018 |
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Mild Traumatic Brain Injury prevented with Omega-3, Resveratrol, etc (in rats) – Oct 2017 |
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10 Oct, 2017 |
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Concussions (traumatic brain injury) getting big press coverage, vitamin D might be both a cause and a solution |
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21 Sep, 2017 |
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Mild Traumatic Brain Injury reduced by Vitamin D – May 2014 |
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07 Aug, 2017 |
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Cognitive decline after traumatic brain injury reduced by Omega-3 (mice) – Nov 2016 |
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06 Dec, 2016 |
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Traumatic brain injury treated by Vitamin D Progesterone Omega-3 and glutamine – May 2013 |
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11 Sep, 2016 |
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High-fructose diet slows recovery from brain injury - TBI, rats - Oct 2015 |
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01 May, 2016 |
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Traumatic Brain Injury in military - vitamin D - 2014 |
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08 Feb, 2016 |
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Vitamin D aided progesterone in reducing traumatic brain injury – RCT Dec 2012 |
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03 Jan, 2015 |