Adiposity may confound the association between vitamin D and disease risk - a lifecourse Mendelian randomization study
Tom G Richardson 1 , Grace M Power 1 , George Davey Smith 1
Elife . 2022 Aug 8;11:e79798 doi: 10.7554/eLife.79798.
Background: Vitamin D supplements are widely prescribed to help reduce disease risk. However, this strategy is based on findings using conventional epidemiological methods which are prone to confounding and reverse causation.
Methods: In this short report, we leveraged genetic variants which differentially influence body size during childhood and adulthood within a multivariable Mendelian randomization (MR) framework, allowing us to separate the genetically predicted effects of adiposity at these two timepoints in the lifecourse.
Results: Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), there was strong evidence that higher childhood body size has a direct effect on lower vitamin D levels in early life (mean age: 9.9 years, range = 8.9-11.5 years) after accounting for the effect of the adult body size genetic score (beta = -0.32, 95% CI = -0.54 to -0.10, p=0.004). Conversely, we found evidence that the effect of childhood body size on vitamin D levels in midlife (mean age: 56.5 years, range = 40-69 years) is putatively mediated along the causal pathway involving adulthood adiposity (beta = -0.17, 95% CI = -0.21 to -0.13, p=4.6 × 10-17).
Conclusions: Our findings have important implications in terms of the causal influence of vitamin D deficiency on disease risk. Furthermore, they serve as a compelling proof of concept that the timepoints across the lifecourse at which exposures and outcomes are measured can meaningfully impact overall conclusions drawn by MR studies.
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VitaminDWiki - 36 studies in both categories infand-Child and Obesity
This list is automatically updated
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Omega-3 added to father’s diet reduced offspring’s obesity (mice) – June 2024
-
Obesity is associated with 1 to 5 poor vitamin D genes (childhood obesity in the case) – July 2024
-
Obese children have poor vitamin D genes (CYP27A1, CYP2R1, CYP27B1) – March 2024
-
Obese children had less gene methylation (gene not work as well) – March 2024
-
Obese asthmatic children Vitamin D - 50,000 IU then 8,000 IU daily - RCT Jan 2024
-
High-dose Vitamin D reduced inflammation and insulin resistance (obese children) - Dec 2023
-
Vitamin D half life is shorter in asthmatic children who are more obese – Nov 2023
-
Childhood BMI decreased when add a little Vitamin D – meta-analysis March 2023
-
Child Obesity and Vitamin D - many studies
-
Recent increases in pediatric endocrine problems may be decreased by Vitamin D – Aug 2022
-
Obese during childhood usually results in obese adult (M.R., not a surprise) - Aug 2022
-
Less obese child if supplemented with Vitamin D as an infant– meta-analysis Feb 2021
-
Obese children had 2.2 X less response to a single dose of Vitamin D – Oct 2020
-
Little weight loss in obese children from very small amount of vitamin D (1200 IU) – RCT April 2020
-
Increased weight in children 8X more likely for each unit increase in adenovirus (if ignore Vitamin D) – Nov 2019
-
Obesity 3X more likely in US children having low vitamin D – July 2019
-
Overweight children are 3.4 X more likely to have low Vitamin D – March 2019
-
Indoor pollution is a problem with obese black asthmatic children – May 2018
-
Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT April 2018
-
The Convergence of Two Epidemics: Vitamin D Deficiency in Obese School-aged Children – Jan 2018
-
NAFLD in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016
-
Omega-3 in infancy reduces Obesity following antibiotic (confirmed in rats, suspected in humans) – Feb 2016
-
Vitamin D deficiency and childhood obesity: interactions, implications, and recommendations (5,000 IU) – Feb 2016
-
Obese children – 71 percent had low vitamin D– Jan 2016
-
Infant risk of obesity increased by 50 percent if low vitamin D during pregnancy – Sept 2015
-
Obese children and youths need more vitamin D – Review Feb 2015
-
Overweight children associated with low vitamin D during pregnancy – 2015, 2018
-
Higher vitamin D at birth associated with less diabetes and obesity 35 years later – Jan 2014
-
More Hypertension in obese children with low vitamin D, especially at night – Dec 2013
-
Very poor follow-thu with vitamin D testing and supplementation of obese children – June 2013
-
Obese children gain weight more quickly when have low vitamin D – Oct 2013
-
Obese mothers with adequate vitamin D gave birth to low D and fat infants – Jan 2013
-
Heavier kids more vitamin D deficient, especially if dark skinned – Pediatrics Dec 2012
-
Obese children with celiac disease had lower levels of vitamin D – April 2012
-
The more vitamin D the lower the infant BMI – March 2011
-
Obama task force told that childhood Obesity linked to Vitamin D Deficiency – Aug 2010
Obese during childhood usually results in obese adult (M.R., not a surprise) - Aug 2022
546 visitors, last modified 08 Aug, 2022,
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This list is automatically updated
- Omega-3 added to father’s diet reduced offspring’s obesity (mice) – June 2024
- Obesity is associated with 1 to 5 poor vitamin D genes (childhood obesity in the case) – July 2024
- Obese children have poor vitamin D genes (CYP27A1, CYP2R1, CYP27B1) – March 2024
- Obese children had less gene methylation (gene not work as well) – March 2024
- Obese asthmatic children Vitamin D - 50,000 IU then 8,000 IU daily - RCT Jan 2024
- High-dose Vitamin D reduced inflammation and insulin resistance (obese children) - Dec 2023
- Vitamin D half life is shorter in asthmatic children who are more obese – Nov 2023
- Childhood BMI decreased when add a little Vitamin D – meta-analysis March 2023
- Child Obesity and Vitamin D - many studies
- Recent increases in pediatric endocrine problems may be decreased by Vitamin D – Aug 2022
- Obese during childhood usually results in obese adult (M.R., not a surprise) - Aug 2022
- Less obese child if supplemented with Vitamin D as an infant– meta-analysis Feb 2021
- Obese children had 2.2 X less response to a single dose of Vitamin D – Oct 2020
- Little weight loss in obese children from very small amount of vitamin D (1200 IU) – RCT April 2020
- Increased weight in children 8X more likely for each unit increase in adenovirus (if ignore Vitamin D) – Nov 2019
- Obesity 3X more likely in US children having low vitamin D – July 2019
- Overweight children are 3.4 X more likely to have low Vitamin D – March 2019
- Indoor pollution is a problem with obese black asthmatic children – May 2018
- Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT April 2018
- The Convergence of Two Epidemics: Vitamin D Deficiency in Obese School-aged Children – Jan 2018
- NAFLD in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016
- Omega-3 in infancy reduces Obesity following antibiotic (confirmed in rats, suspected in humans) – Feb 2016
- Vitamin D deficiency and childhood obesity: interactions, implications, and recommendations (5,000 IU) – Feb 2016
- Obese children – 71 percent had low vitamin D– Jan 2016
- Infant risk of obesity increased by 50 percent if low vitamin D during pregnancy – Sept 2015
- Obese children and youths need more vitamin D – Review Feb 2015
- Overweight children associated with low vitamin D during pregnancy – 2015, 2018
- Higher vitamin D at birth associated with less diabetes and obesity 35 years later – Jan 2014
- More Hypertension in obese children with low vitamin D, especially at night – Dec 2013
- Very poor follow-thu with vitamin D testing and supplementation of obese children – June 2013
- Obese children gain weight more quickly when have low vitamin D – Oct 2013
- Obese mothers with adequate vitamin D gave birth to low D and fat infants – Jan 2013
- Heavier kids more vitamin D deficient, especially if dark skinned – Pediatrics Dec 2012
- Obese children with celiac disease had lower levels of vitamin D – April 2012
- The more vitamin D the lower the infant BMI – March 2011
- Obama task force told that childhood Obesity linked to Vitamin D Deficiency – Aug 2010
546 visitors, last modified 08 Aug, 2022, |