Influence of Various Factors on Circulating 25(OH) Vitamin D Concentrations in Dogs with Cancer and Healthy Dogs.
J Vet Intern Med. 2017 Sep 23. doi: 10.1111/jvim.14834. [Epub ahead of print]
Weidner N1, Woods JP1, Conlon P2, Meckling KA3, Atkinson JL4, Bayle J5, Makowski AJ6, Horst RL6, Verbrugghe A1.
|Diagnosed with Cancer in lifetime||25%||38%|
|Other diseases also associated with low D||Yes||Yes|
|Diseases associated with CYP24A1 gene||Yes||Yes|
|Decreased Vitamin D in food/supplements associated with Cancer||Yes||Yes|
|Vitamin D reduces pain of arthritis, etc.||Yes||Yes|
- Half of dogs now get cancer, it used to be just 1 percent (probably low Vitamin D)
- Dog Cancer 4X more likely if low Vitamin D – Nov 2015
- Dog Cancer (hemangiosarcoma) is rare if more than 100 ng of vitamin D – July 2014
Note 100 ng is the minmum recommended vitamin D level for dogs
- Vitamin D is great for dogs too
- Companion animals (dog, cats) need vitamin D too – March 2016
- Hospitalized cats 8X more likely to die if low vitamin D (Vit. D helps humans too) – May 2015
- Rickets increasing in dogs
- Overview Veterinary and vitamin D
Vets give 3X vitamin D than the US govt recommends for animal OR humans
Vets are paid to keep their "patients" healthy, rather than being getting money when "patients" become sick
Cancer category (for humans) starts with the following
199 items Overview Cancer and vitamin D
- After Cancer Diagnosis
- Bladder Cancer
- Breast Cancer
212 items Overview Breast Cancer and Vitamin D
- Colon Cancer
105 items Overview Cancer-Colon and vitamin D
- Lung Cancer
45 items Overview Lung cancer and vitamin D
- Lymphoma Cancer
- Other Cancer
- Prostate Cancer
87 items Prostate Cancer and Vitamin D studies
- Pancreatic Cancer
- Skin Cancer
104 items Overview Suntans melanoma and vitamin D
- Evidence that Vitamin D prevents Cancer – Grant Feb 2018
- Cancer risk in older women reduced 32 percent by 2,000 IU of Vitamin D plus Calcium – 4 year RCT Oct 2016
- Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
- Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
- Pancreatic cancer 55 percent less likely if optimal vitamin D (vs low) – Nov 2017
- Melanoma 25 X more likely if low vitamin D – Feb 2018
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018
- Risk of Cancer increased due to Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer not treated by Vitamin D when ignore dose size, type, and length of trial – meta-analysis April 2018
Low blood 25-hydroxyvitamin D (25(OH)D) concentrations have been associated with cancer in dogs. Little research has examined what other factors may affect 25(OH)D concentrations.
(1) To determine whether the presence of cancer (lymphoma, osteosarcoma, or mast cell tumor [MCT]) in dogs is associated with plasma 25(OH)D concentrations and (2) identify other factors related to plasma 25(OH)D concentrations in dogs.
Dogs newly diagnosed with osteosarcoma (n = 21), lymphoma (n = 27), and MCT (n = 21) presented to a tertiary referral oncology center, and healthy, client-owned dogs (n = 23).
An observational study design was used. Dietary vitamin D intake, sex, age, body condition score (BCS), muscle condition score (MCS), and plasma concentrations of 25(OH)D, 24,25-dihydroxyvitamin D (24,25(OH)2 D) (a marker of CYP24A1 activity), as well as ionized calcium (ICa), parathyroid hormone, and parathyroid hormone-related protein concentrations were measured. An analysis of covariance was used to model plasma 25(OH)D concentrations.
Cancer type (P = 0.004), plasma 24,25(OH)2 D concentrations (P < 0.001), and plasma ICa concentrations (P = 0.047) had significant effects on plasma 25(OH)D concentrations. Effects of age, sex, body weight, BCS, MCS, and plasma PTH concentrations were not identified. A significant interaction between ICa and cancer was found (P = 0.005). Plasma 25(OH)D concentrations increased as ICa concentrations increased in dogs with cancer, whereas plasma 25(OH)D concentrations decreased as ICa concentrations increased in healthy dogs.
CONCLUSIONS AND CLINICAL IMPORTANCE:
Results support a relationship between cancer and altered vitamin D metabolism in dogs, mediated by plasma ICa concentrations. The CYP24A1 activity and plasma ICa should be measured in studies examining plasma 25(OH)D concentrations in dogs.
PMID: 28941306 DOI: 10.1111/jvim.14834
- After Cancer Diagnosis