Dogs with Cancer have low vitamin D, same as humans – Sept 2017

Influence of Various Factors on Circulating 25(OH) Vitamin D Concentrations in Dogs with Cancer and Healthy Dogs.

J Vet Intern Med. 2017 Sep 23. doi: 10.1111/jvim.14834. [Epub ahead of print]
Weidner N1, Woods JP1, Conlon P2, Meckling KA3, Atkinson JL4, Bayle J5, Makowski AJ6, Horst RL6, Verbrugghe A1.

VitaminDWiki Summary
DogsHumans
Diagnosed with Cancer in lifetime25%38%
Other diseases also associated with low DYesYes
Diseases associated with CYP24A1 gene YesYes
Decreased Vitamin D in food/supplements associated with Cancer YesYes
Vitamin D reduces pain of arthritis, etc.YesYes

VitaminDWiki - Overview Veterinary and vitamin D contains

Veterinary category has 147 items

Animals need Vitamin D too

Pets as well

Farm Vets are paid when their "patients" are healthy,
   vs doctors who are paid only when "patients" become sick

_Cows are routinely given 30 IU per kilogram (which would be 10,000 IU for a 150 lb person)
Same information is available on Cattle need 66 IU of vitamin D per pound
The US RDA of vitamin D for cows is 13 IU per kilogram (which would be 4,300 IU for a 150 lb 'cow')
Virtually all US farmers who raise livestock use feed which is supplemented with vitamin D
Merick Vet Manual supplement if not have UV or sunlight

+Vets give 3X vitamin D than the US govt recommends for animal OR humans +Vets are paid to keep their "patients" healthy, rather than being getting money when "patients" become sick

Cancer category (for humans) starts with the following


Cancers get less Vitamin D when there is a poor Vitamin D Receptor


VitaminDWiki Vet category with CANCER in title

This list is automatically updated

Items found: 5


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BACKGROUND:
Low blood 25-hydroxyvitamin D (25(OH)D) concentrations have been associated with cancer in dogs. Little research has examined what other factors may affect 25(OH)D concentrations.

OBJECTIVES:
(1) To determine whether the presence of cancer (lymphoma, osteosarcoma, or mast cell tumor [MCT]) in dogs is associated with plasma 25(OH)D concentrations and (2) identify other factors related to plasma 25(OH)D concentrations in dogs.

ANIMALS:
Dogs newly diagnosed with osteosarcoma (n = 21), lymphoma (n = 27), and MCT (n = 21) presented to a tertiary referral oncology center, and healthy, client-owned dogs (n = 23).

METHODS:
An observational study design was used. Dietary vitamin D intake, sex, age, body condition score (BCS), muscle condition score (MCS), and plasma concentrations of 25(OH)D, 24,25-dihydroxyvitamin D (24,25(OH)2 D) (a marker of CYP24A1 activity), as well as ionized calcium (ICa), parathyroid hormone, and parathyroid hormone-related protein concentrations were measured. An analysis of covariance was used to model plasma 25(OH)D concentrations.

RESULTS:
Cancer type (P = 0.004), plasma 24,25(OH)2 D concentrations (P < 0.001), and plasma ICa concentrations (P = 0.047) had significant effects on plasma 25(OH)D concentrations. Effects of age, sex, body weight, BCS, MCS, and plasma PTH concentrations were not identified. A significant interaction between ICa and cancer was found (P = 0.005). Plasma 25(OH)D concentrations increased as ICa concentrations increased in dogs with cancer, whereas plasma 25(OH)D concentrations decreased as ICa concentrations increased in healthy dogs.

CONCLUSIONS AND CLINICAL IMPORTANCE:
Results support a relationship between cancer and altered vitamin D metabolism in dogs, mediated by plasma ICa concentrations. The CYP24A1 activity and plasma ICa should be measured in studies examining plasma 25(OH)D concentrations in dogs.

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