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Poor immune system associated with low Vitamin D (dogs in this case) – June 2020

Immune function and serum vitamin D in shelter dogs: A case-control study

Vet J. 2020 Jul;261:105477. doi: 10.1016/j.tvjl.2020.105477
L N Allison 1, J A Jaffey 2, N Bradley-Siemens 3, Z Tao 1, M Thompson 4, R C Backus 5


Immunity category starts with

219 items in Immunity category

    see also

Virus category listing has 735 items along with related searches

Overview Influenza and vitamin D
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
141 VitaminDWiki pages contained "infection" in title (June 2021)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021 nothing about Vitamin D
13 titles in VitaminDWiki contained INNATE or ADAPTIVE as of July 2021
Increasing publications on vitamin D and Infection

33 studies are in both Immunity and Virus categories

Overview Veterinary and vitamin D has the following

Veterinary category has 136 items

Vets give 3X vitamin D than the US govt recommends for animal OR humans

Farm Vets are paid when their "patients" are healthy,
   vs doctors who are paid only when "patients" become sick

A few Vet items in VitaminDWiki

Cows are routinely given 30 IU per kilogram (which would be 10,000 IU for a 150 lb person)

Same information is available on Cattle need 66 IU of vitamin D per pound
The US RDA of vitamin D for cows is 13 IU per kilogram (which would be 4,300 IU for a 150 lb 'cow')

Virtually all US farmers who raise livestock use feed which is supplemented with vitamin D
Merick Vet Manual supplement if not have UV or sunlight
Parrot-like birds are given 600 IU per pound of feed

The cow experts probably base their ideas on

- what is needed,
- what actually works,
- what is cost effective (vitamin D for a cow costs about $1/year), and
- what does not have ANY long-term bad side-affects

Vet-grade Vitamin D: $50 million for the entire US population for a year.

Cow owners use really low cost vitamin D
Vitamin D costs the owner $1/cow for an entire year for a dose rate which is effectively 10,000 IU for a normal weight human.
Assuming that you want to give say 7,000 IU of vitamin D to every person in the US
And since a person weighs about 1/5 that of a cow, 7,000 IU vitamin D would be about 16 cents per year (vet grade)
Thus the cost of vet-grade vitamin D for the entire US population would be approximately
311 million * 16 cents = $50 million

 Download the PDF from sci-hub via VitaminDWiki

This study sought to establish a baseline understanding of immune function and its association with serum vitamin D in shelter dogs. Ten apparently healthy shelter dogs housed in the Arizona Humane Society for ≥7 days and 10 apparently healthy, age, breed, and sex-matched control dogs were included. Serum 25-hydroxyvitamin D (25[OH]D), the major circulating vitamin D metabolite, was measured using high performance liquid chromatography. Whole blood samples were stimulated with lipopolysaccharide (LPS), lipoteichoic acid, or phosphate buffer solution, and tumor necrosis factor (TNF)-ɑ, interleukin (IL)-6, and IL-10 were measured using a canine-specific multiplex bead-based assay. Phagocytosis of opsonized-Escherichia coli and E. coli-induced oxidative burst were evaluated with flow cytometry. Shelter dogs had decreased percentages of granulocytes and monocytes (GM) that had phagocytized opsonized-E coli (P = 0.019) and performed E. coli-induced oxidative burst (P = 0.011). There were no significant differences in TNF-α, IL-6, IL-10, or 25(OH)D concentrations between shelter and control dogs. Serum 25(OH)D concentrations had a weak positive association with the intensity of GM E. coli-induced oxidative burst (r2 = 0.23, P = 0.03). There was a moderate inverse association between serum 25(OH)D concentration and LPS-stimulated TNF-ɑ production in shelter dogs (r2 = 0.40, P = 0.04). These results demonstrate immune dysregulation in vitro in shelter dogs housed for ≥7 days when compared to age, breed, and sex-matched control dogs.
While serum 25(OH)D concentrations did not differ between shelter and control dogs, significant associations between 25(OH)D concentration and immune function parameters in vitro were identified.

Created by admin. Last Modification: Saturday August 8, 2020 19:36:44 GMT-0000 by admin. (Version 2)

Attached files

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14120 Dog Immunity sci-hub.pdf PDF 2020 admin 05 Aug, 2020 13:05 1.32 Mb 162
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