- Effects of Omega-3 Fatty Acids on Postoperative Inflammatory Response: A Systematic Review and Meta-Analysis
- VitaminDWiki - 23 Omega-3 meta-analyses
- VitaminDWiki - Overview: Omega-3 many benefits include helping vitamin D
- VitaminDWiki - Omega-3 helps many health problems
- 60+ VitaminDWiki pages have TRANSCRIPT in the title
Effects of Omega-3 Fatty Acids on Postoperative Inflammatory Response: A Systematic Review and Meta-Analysis
Nutrients 2023, 15(15), 3414; https://doi.org/10.3390/nu15153414
Ghaith Mohsen 1,*,Annika Stroemer 2ORCID,Andreas Mayr 2ORCID,Andrea Kunsorg 1,Christian Stoppe 3,4ORCID,Maria Wittmann 1ORCID and Markus Velten 1ORCID
Initial evidence indicates that preoperatively initiated administration of omega-3 fatty acids (FAs) attenuates the postoperative inflammatory reaction. The effects of immunonutrition containing omega-3 FAs, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on the inflammatory response to abdominal surgery continues to be unclear, although improved outcomes have been reported. Therefore, we determined the effectiveness of preoperatively initiated omega-3 FAs administration on postoperative inflammation defined as CRP (C-Reactive Protein), IL-6 (Interleukin 6), and WBC (White Blood Count) and potential effects on postoperative length of hospital stay (LOS) due to an improved inflammatory response.
Methods: a literature search of Cochrane Library was conducted to identify all randomized controlled trials (RCTs) investigating the effects of preoperatively initiated omega-3 to standard care, placebo, or other immunonutrients excluding omega-3 FAs in patients undergoing abdominal surgery until the end of December 2022.
Results: a total of 296 articles were found during the initial search. Thirteen RCTs involving 950 patients were identified that met the search criteria. These were successively analyzed and included in this meta-analysis. There was no significant difference between the groups with respect to inflammatory markers IL-6: −0.55 [−1.22; 0.12] p = 0.10, CRP: −0.14 [−0.67; 0.40] p = 0.55, WBC: −0.58 [−3.05; 1.89] p = 0.42, or hospital stay −0.5 [−1.43; 0.41] p = 0.2.
Conclusion: although reduced inflammatory markers were observed, preoperative administration of omega-3 FAs immunonutrients had no significant effect on the postoperative inflammatory response in patients undergoing abdominal surgeries. Yet, results obtained from this study are inconclusive, likely attributed to the limited number of trials and patients included. Further studies are required to obtain a better educated verdict.
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The mistake of trying to find a benefit from small doses for a short time is often a problem for Omega-3, Vitamin D, Magnesium, etc.
Probably need 1 gram/day pf Omega-3 for months, with fatty meal, AND Omega-6 intake MUST be reduced
- Omega-6 blocks Omega-3 etc. -many studies
- Emulsified form of Omega-3 is 3X more bioavailable in low fat meal – Dec 2019
VitaminDWiki - 23 Omega-3 meta-analyses
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- Small doses for a short time rarely help (Omega-3, post surgery this time) – meta-analysis Nov 2023
- Eating Fish – 17 health benefits (Omega-3 and perhaps Vitamin D) – umbrella review Feb 2023
- Blood pressure reduced if take more than 4.5 grams of Omega-3 daily– umbrella meta-analysis Aug 2022
- Omega-3 increases Vitamin D levels – Meta-analysis May 2022
- Omega-3 improves elderly muscles – 2 meta-analyses
- Mental disorders fought by Omega-3 etc. - meta-meta-analysis Oct 2019
- Breast Cancer reduced 20 percent by fish (Omega-3) – meta-analysis Feb 2019
- Anxiety severity reduced if more than 2 grams of Omega-3 – meta-analysis Sept 2018
- ICU length of stay reduced when supplement with Omega-3 – meta-analysis July 2018
- Breast Cancer rate reduced by 40 percent with Omega-3 – meta-analysis June 2013
- Omega-3 reduced time in hospital and atrial fibrillation after cardiac surgery – meta-analysis May 2016
- Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017
- 2.7 fewer days in hospital after surgery if had taken Omega-3 (19 RCT) – meta-analysis – June 2017
- Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017
- Health problems prevented by eating nuts (perhaps due to Magnesium and or Omega-3) – meta-analysis Dec 2016
- Non-Alcoholic Fatty Liver Disease treated by Omega-3 – three meta-analysis 2016-2017
- Omega-3 helps childhood cognition – meta-analysis April 2016
- Preterm birth extended by 2 weeks with Omega-3 – Meta-analysis Nov 2015
- Atrial fibrillation sometimes treated by Omega-3 – meta-analysis Sept 2015
- Cognitive decline in elderly slowed by Omega-3 – meta-analysis May 2015
- Hypertension reduced by Omega-3, especially if previously untreated – meta-analysis July 2014
- Omega-3 does not help heart patients – meta-analysis Sept 2012
- Vitamin D and omega-3 are the only supplements which show benefit in meta-analysis – Jan 2012
VitaminDWiki - Overview: Omega-3 many benefits include helping vitamin D
(414) items in category Omega-3 and Vitamin D- Omega-3 reduces risk of COVID-19 - many studies
- Cardiovascular problems reduced by Omega-3 - many studies
- Omega-3 helps muscles - many studies
- Omega 3 increases vitamin D in the blood – many studies
- Omega-3 index - many studies
- Preterm birth decreased by Omega-3, etc. - many studies
- Omega-3 reduces many psychiatric disorders – 2 reviews 2016
- ADHD, Autism, Early Psychosis and Omega-3 – review Dec 2017
- Schizophrenia relapses reduced 3X by Omega-3 – RCT Mar 2015
- Typical pregnancy is now 39 weeks – Omega-3 and Vitamin D might restore it to full 40 weeks
- Omega-3 supplementation during pregnancy reduce early preterm births (save 1500 USD per child) – Aug 2016
- Infants getting 1 g of Omega-3 for 12 weeks got better brains – RCT March 2017
- Omega-3 conference and 12 publications – Nov 2014
- Vitamin D Cofactors in a nutshell by VitaminDWiki
- For every Omega-3 dollar there is a 84 dollar savings in Cardiovascular costs - Foster and Sullivan April 2016
- Overweight women on caloric restriction diet got 3X benefits from 8 weeks of Omega-3 – RCT Dec 2015
- 2.7 fewer days in hospital after surgery if had taken Omega-3 (19 RCT) – meta-analysis – June 2017
- Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017
- Omega-7 - in addition to Omega-3
- Consuming more monounsaturated fat increased vitamin D – Aug 2011 has the following
WikiPedia Good (more vitamin D into bloodstream)= much more BLUE than Green
Almonds and macadamia nuts are examples of good foods to take with vitamin D
VitaminDWiki - Omega-3 helps many health problems
414 Omega-3 items in category Omega-3 helps with: Autism (7 studies), Depression (28 studies), Cardiovascular (34 studies), Cognition (53 studies), Pregnancy (46 studies), Infant (34 studies), Obesity (14 studies), Mortality (7 studies), Breast Cancer (5 studies), Smoking, Sleep, Stroke, Longevity, Trauma (12 studies), Inflammation (19 studies), Multiple Sclerosis (9 studies), VIRUS (12 studies), etcCIlck here for details
60+ VitaminDWiki pages have TRANSCRIPT in the title
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