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Omega-3 increases Vitamin D levels – Meta-analysis May 2022

The influence of omega-3 supplementation on vitamin D levels in humans: a systematic review and dose-response meta-analysis of randomized controlled trials

Critical Reviews in Food Science and Nutrition Vol 62, 2022 - Issue 11 Pages 3116-3123 | online: 25 Dec 2020
Habeeb Alhabeeb,Hamed Kord-Varkaneh,Shing Cheng Tan,Mihnea-Alexandru Găman,Bander Yayha Otayf, Almuhannad Ali Qadri,

Need at least 1000 mg of Omega-3

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Omega-3 increased Vitamin D by 20% if Vitamin D <12 ng or >37 ng

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Background
Inconsistencies exist with regard to the influence of omega-3 supplementation on 25-hydroxyvitamin D (25(OH)D) levels, which could be attributed to many factors, such as the duration and dose of omega-3 supplementation, and individuals’ baseline 25(OH)D levels. Therefore, to address the inconsistencies, we conducted a systematic review and dose-response meta-analysis to accurately determine the effect of omega-3 supplementation on 25(OH)D levels in humans.

Methods
We performed a comprehensive literature search in Web of Science, PubMed/Medline, Scopus, and Embase databases from inception up to January 2020. We included only randomized controlled trials (RCTs). We used weighted mean difference (WMD) with 95% confidence interval (CI) to assess the influence of omega-3 supplementation on serum 25(OH)D levels using the random-effects model.

Results
Our pooled results of 10 RCTs demonstrated an overall significant increase in 25(OH)D levels following omega-3 intake (WMD = 3.77 ng/ml, 95% CI: 1.29, 6.25). In addition, 25(OH)D levels were significantly increased when the intervention duration lasted >8 weeks and when the baseline serum 25(OH)D level was ˂20 ng/ml. Moreover, omega-3 intake ≤1000 mg/day resulted in higher 25(OH)D levels compared to omega-3 intake >1000 mg/day.

Conclusion
In conclusion, omega-3 supplementation increased 25(OH)D concentrations, particularly with dosages ≤1000 mg/day and intervention durations >8 weeks.
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VitaminDWiki - Omega-3 helps many health problems

409 Omega-3 items in category Omega-3 helps with: Autism (7 studies), Depression (28 studies), Cardiovascular (34 studies), Cognition (52 studies), Pregnancy (45 studies), Infant (34 studies), Obesity (14 studies), Mortality (7 studies), Breast Cancer (5 studies), Smoking, Sleep, Stroke, Longevity, Trauma (12 studies), Inflammation (18 studies), Multiple Sclerosis (9 studies), VIRUS (12 studies), etc
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Omega-3 index measurement in blood is a far better measure than Omega-3 consumption

Suspect far larger increase if they had considered only those with Omega-3 index > 6

VitaminDWiki pages with OMEGA-3 INDEX in title (21 as of March 2024)

This list is automatcially updated

Items found: 21
Title Modified
High Omega-3 index increases longevity, even among smokers - Patrick Jan 2024 17 Jan, 2024
Omega-3 index: 70% of Grassrootshealth participants have less than 8% - Dec 2023 25 Dec, 2023
Omega-3 index - many studies 25 Dec, 2023
Better cognition associated with higher Omega-3 index – Sept 2023 01 Nov, 2023
Alzheimer’s delayed 4.7 years by high Omega-3 index (7.6 years if also have APOE-4) June - 2022 17 Jun, 2022
4X fewer COVID-19 deaths in those having high Omega-3 index – Jan 6, 2021 13 Jan, 2021
2X less muscle soreness after exercise if Omega-3 index higher than 4 – RCT 2014 23 Dec, 2019
Omega-3 index study by Grassroots Health – Nov 2019 21 Nov, 2019
Omega-3 index of 6 to 7 associated with best cognition in this study – Nov 2019 10 Nov, 2019
Omega-3 – Chart of index vs ratio by GrassrootsHealth – Sept 2019 25 Oct, 2019
Omega-3 index of 8 to 11 is optimal (German) - Oct 2019 15 Oct, 2019
Depression after childbirth 5 X less likely if good Omega-3 index – April 2019 03 Aug, 2019
No NCAA player had a healthy Omega-3 index – Jan 2019 19 Jan, 2019
Omega-3 index of 5 greatly decreases the risk of an early preterm birth – Dec 2018 04 Jan, 2019
Innocent Dietary Imbalance Hardens and Narrows Your Arteries (Omega-3 index) – Dec 2018 10 Dec, 2018
Omega-3 index - good level needed 2.4 grams of regular Omega-3 - Grassroots Nov 2018 28 Nov, 2018
Omega-3 index replaces the Omega-6 to Omega-3 ratio – March 2018 16 Apr, 2018
Blood pressure 4 mm lower if Omega-3 index was high – March 2018 16 Apr, 2018
Omega-3 supplement better than farmed salmon at raising Omega-3 index – RCT Feb 2018 25 Feb, 2018
Increased Omega-3 index (4 to 8 percent) decreases coronary disease by 30 percent (10 studies) July 2017 15 Dec, 2017
Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017 14 Dec, 2017

VitaminDWiki Omega-3 category pages with VITAMIN in title (139 as of March 2024)

This list is automatically updated

Items found: 145
Title Modified
Intestinal permeability during pregnancy - maintained by Vitamin D, Omega-3, etc. - March 2025 10 Jan, 2025
Some supplements: Vitamin D, Vitamin K, Omega-3, etc. must be taken with fatty meals (there are other forms) 24 Nov, 2024
Vitamin D and Omega-3 benefits to pregnancy and infants 28 Sep, 2024
Vitamin D, Omega-3, and Magnesium are synergistic - many studies 14 Sep, 2024
How Vitamin D, Magnesium, Omega-3 and Zinc prevent and treat COVID-19 etc. – June 2021 01 Aug, 2024
Top 3 Supplements to Regenerate Stem Cells and Live Longer (Vitamin D, Omega-3, Magnesium) - video July 2024 06 Jul, 2024
These 3 supplements are a no brainer (Vitamin D, Magnesium, Omega-3) - video July 2024 05 Jul, 2024
Dementia prevented by Omega-3, Vitamin D, etc. book and video May 2024 30 May, 2024
Overview: Omega-3 many benefits include helping vitamin D 07 Dec, 2023
Longevity experts take Vitamin D, Omega-3, and Magnesium - Patrick video Sept 2023 10 Nov, 2023
How Vitamin D, Omega-3s, and Exercise May Increase Longevity - Patrick Nov 2023 10 Nov, 2023
Stillbirth reduced by Vitamin D, Zinc, Omega-3 - several studies 14 Oct, 2023
NAFLD in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016 21 Aug, 2023
The End of Alzheimer's and Dementia if adjust Vitamin D, B-12, Iron, Omega-3, etc. 19 Aug, 2023
ADHD and Vitamin D Deficiency 19 Jul, 2023
Low cost cofactors for vitamin D 18 Jul, 2023
Cluster headaches virtually eliminated in 7,000 people with high-dose vitamin D and cofactors - Feb 2022 16 Jul, 2023
Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies 11 Jul, 2023
increased Periodontal Disease risk if low Vitamin D, Magnesium, Omega-3 - GRH March 2023 20 Mar, 2023
Eating Fish – 17 health benefits (Omega-3 and perhaps Vitamin D) – umbrella review Feb 2023 27 Feb, 2023
Vitamin D and Omega-3 17 Feb, 2023
Cardiovascular problems are prevented by Vitamin D plus Omega-3 – Feb 2023 17 Feb, 2023
Dry Eyes treated by Omega-3 and Vitamin D – many studies 11 Feb, 2023
Endometriosis treated, and perhaps prevented, by vitamin D - many studies 29 Dec, 2022
Omega 3 increases vitamin D in the blood – many studies 06 Jul, 2022
Anxiety, depression, and suicide have recently surged (Note: Vitamin D, Omega-3, and Magnesium help) – May 2022 29 May, 2022
Omega-3 increases Vitamin D levels – Meta-analysis May 2022 20 May, 2022
Preterm birth might be prevented by Vitamin D, Omega-3, etc. (International survey) – Jan 2019 15 May, 2022
Preterm Births - promising preventions – anti-oxidants, Vitamin D, Omega-3, Zinc, etc. – Jan 2019 15 May, 2022
Preterm birth reduction by nutrients - Vitamin D is the best, Omega-3 is next best – May 2022 15 May, 2022
2.5 X reduced risk of cancer in 70 year-olds by a small amount of Vitamin D, Omega-3 and exercise – RCT April 2022 25 Apr, 2022
COVID-19 risk reduced 4X by each of: Vitamin D, Omega-3, Curcumin, Zinc (each increases D in cells) 13 Apr, 2022
Vitamin D reduces RTI, Omega-3 reduces wheezing or asthma – March 2022 11 Apr, 2022
Cluster Headaches treated by high-dose Vitamin D, etc. (interview and transcript) - Feb 2022 23 Feb, 2022
How vitamins A, B, C, D, E, F (Omega), K fight COVID - Feb 2022 14 Feb, 2022
Autoimmune risk decreased 30 percent by small amount of vitamin D and or Omega-3 – ViTAL Nov 7 2021 27 Jan, 2022
Autoimmune risk decreased 30 percent by small amount of vitamin D and or Omega-3 – ViTAL Nov 7 2021 27 Jan, 2022
NAFLD not reduced by 1680 IU of vitamin D plus Omega-3 (no surprise) – RCT Jan 2022 24 Jan, 2022
FDA allows 2 specific Vitamin D and 2 Omega-3 health claims - 2019 31 Dec, 2021
Dementia 4.1 X high risk in those with low Vitamin D, Omega-3, etc.2 decades before (behind paywall) – Nov 2021 22 Nov, 2021
Mental health not helped by vitamin D monotherapy (adding Omega-3 and Magnesium help) – review Nov 2021 05 Nov, 2021
COVID-19 decreased risk if add Vitamin D, A, C, NAC, Se, Zn, or Omega-3 – Dec 2021 01 Nov, 2021
Early brain development helped by Iron, Iodine, Vitamin D, Omega-3. Zinc etc. – Oct 2021 08 Oct, 2021
Benefits of Omega-3 plus Vitamin D were additive – RCT Sept 2021 27 Sep, 2021
Reasons for low response to vitamin D 22 Sep, 2021
Colorectal Cancer treatment aided by omega-3 plus weekly Vitamin D – RCT Sept 2019 25 Jul, 2021
Prostate Cancer PSA reduced by 60 ng of Vitamin D, Vitamin B complex, Omega-3, Curcumin and diet – June 2021 20 Jun, 2021
Many supplements appear to fight COVID-19 – vitamin D cited 52 times – May 2021 05 May, 2021
Rett syndrome associated with low vitamin D, treated by Omega-3 26 Apr, 2021
COVID-19 Cytokine storms attenuated by Vitamin D, Omega-3, Mg, Resveratrol, etc – April 2021 18 Apr, 2021
Pregnancy recommendations – huge differences in Vitamin D, Mg, iron, Iodine, DHA, etc – April 2021 13 Apr, 2021
Vitamin D Cofactors in a nutshell 17 Mar, 2021
Some Religious dietary practices may result in low iron, B12, vitamin D, Zinc, etc. 29 Nov, 2020
ADHD risk factors include low Zinc, Vitamin D, Magnesium and Omega-3 (umbrella review) – Oct 2020 20 Oct, 2020
Less muscle loss associated with eating more fish (Omega-3, Vitamin D, Magnesium, etc) – Jan 2020 30 Jan, 2020
Depression treatments: diet, exercise, bright light, Vitamin D, B12, Omega-3, Zinc, Music, etc. – May 2019 08 Dec, 2019
Magnesium, Vitamin D, Omega-3, TSH - importance and testing - Dean and Baggerly - Oct 2019 30 Oct, 2019
T1 Diabetes treated by Vitamin D and Omega-3 - Jan 2018 23 Oct, 2019
Vitamin D 5,000-8,000 IU and Omega-3 2.5 grams– Life Extension Nov 2019 19 Oct, 2019
Type 1 diabetes trial having problems getting participants – too many taking Vitamin D or Omega-3 – Aug 2019 03 Oct, 2019
Multiple Sclerosis 40 percent less likely if consume tinned fish (Vitamin D and Omega-3) – Sept 2019 30 Sep, 2019
T1 Diabetes reduction by high Omega-3 and Vitamin D – GRH ongoing observation 12 Sep, 2019
Fat-soluble vitamins critical for conception, pregnancy and breast feeding (pigs) – Sept 2019 02 Sep, 2019
Preterm Births reduced by Omega-3, Zinc, and Vitamin D – Aug 2019 09 Aug, 2019
Inflammation is reduced by each of the following: Vitamin D, Omega-3, Diet 01 Jul, 2019
Food allergies in children may be due to earlier low Vitamin D, Omega-3 and Zinc – Aug 2017 24 Jun, 2019
Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019 25 Apr, 2019
Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019 11 Apr, 2019
Omega-3 helped Alzheimer’s only if good level of B vitamins – RCT April 2019 10 Apr, 2019
Estradiol, vitamin D, Omega-3 – RCT Feb 2019 05 Feb, 2019
Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016 19 Jan, 2019
World's Top Authors in Vitamin D, VDR, Vitamin K, Omega-3, etc - Jan 2019 12 Jan, 2019
Vitamin D search term popularity in Mercola and Google in 2018 24 Dec, 2018
Autism treated in one person by Omega-3 plus Vitamin D – Dec 2018 14 Dec, 2018
Heart problems such as Afib related to little Magnesium, Omega-3, Vitamin D getting to tissues 14 Dec, 2018
APOE4 gene problems (Alzheimer’s) reduced by both Vitamin D and Omega-3 - Dec 2018 12 Dec, 2018
Healthy aging associated with higher levels of both Vitamin D and Omega-3 – Dec 2018 12 Dec, 2018
Vitamin D and Omega-3 may treat Type 1 Diabetes – RCT 2024 24 Nov, 2018
Vitamin D and Omega-3 Ineffective for Preventing Cancer and Heart Disease (too little was used) – Nov 2018 21 Nov, 2018
Farmed fish have 2X less Omega-3, 4X less Vitamin D – May 2017 18 Nov, 2018
Omega-3 reduced vitamin D3 inflammation for obese – RCT Jan 2013 03 Nov, 2018
Autism problems reduced by Vitamin D, Omega-3 – RCT Oct 2018 30 Oct, 2018
Less DNA repair if nutrient deficient (Vitamin D, Magnesium, Omega-3, Vitamin K, etc) – Ames Oct 2018 19 Oct, 2018
NAFLD is treated by Vitamin D, Omega-3, Curcumin, Silymarinm, etc. Aug 2018 26 Aug, 2018
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3) 01 Aug, 2018
Pancreatic Cancer is increasing – Vitamin D and Omega-3 should reduce the risk 23 Jul, 2018
PCOS treated by a combination of Vitamin D and Omega-3 – RCT Oct 2018 11 Jul, 2018
Multiple Sclerosis treated by 50,000 IU Vitamin D bi-weekly plus Omega-3 – RCT July 2018 06 Jul, 2018
Improve Cognitive Health and Memory with Vitamin D and Omega-3 – World Patent March 2018 28 Jun, 2018
Adding Vitamin D, Omega-3, etc to children’s milk improved memory (yet again) – RCT June 2018 09 Jun, 2018
Olympic Committee consensus on Vitamin D, Omega-3, Zinc, etc– May 2018 07 May, 2018
Pollutants increase Respiratory problems, Vitamin D, Omega-3, etc. decrease them – May 2018 05 May, 2018
Vitamin K2 and Omega-3 associations (how about a vitamin D association) – 2018 01 May, 2018
Italian consensus of recommended Vitamin D, Omega-3, etc – Oct 2016 27 Apr, 2018
Live longer if high Vitamin D or Omega-3 (probably both) 04 Apr, 2018
Omega-3, Vitamin D, Folic acid etc. during pregnancy and subsequent mental illness of child – March 2018 29 Mar, 2018
Depression – is it reduced by Vitamin D and or Omega-3 – RCT 2019 09 Mar, 2018
During NFL season – Omega-3 down by 2.5 points while Vitamin D up by 9 ng – March 2018 03 Mar, 2018
Fish oil increased Vitamin D levels, krill oil decreased them – RCT Jan 2018 27 Jan, 2018
Supplementation while pregnant and psychotic – 20 percent Omega-3, 6 percent Vitamin D – June 2016 20 Jan, 2018
Vitamin D use increased 3.7 X, Omega-3 increased 9 X (US 1999-2012) – JAMA Oct 2016 17 Jan, 2018
Gestational diabetes treated by Vitamin D plus Omega-3 – RCT Feb 2017 02 Jan, 2018
Diesel air pollution causes liver problems (and low vitamin D) if low Omega-3 (mice) – Jan 2018 25 Nov, 2017
Preterm births strongly related to Vitamin D, Vitamin D Receptor, Iodine, Omega-3, etc 13 Nov, 2017
Can burn pain be relieved by 4 g of Omega-3 and 2,000 IU of vitamin D – RCT due 2021 18 Oct, 2017
Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017 11 Oct, 2017
5 supplements that flat out work (Omega-3, Vitamin D, etc.) - examine.com Oct 2017 08 Oct, 2017
Prostate Cancer treatment (Vitamin D, Omega-3, Tumeric) RCT ending Dec 2018 26 Sep, 2017
Cardiovascular calcification prevented by Omega-3, Magnesium, Vitamin K, and Vitamin D – April 2015 09 Aug, 2017
Importance of Vitamin D and fish rarely mentioned during midwife-led prenatal booking visits – July 2017 07 Aug, 2017
Omega-3 reduced fractures by a quarter (note: Omega-3 increases vitamin D in cells by a quarter) – July 2017 31 Jul, 2017
Fish (Omega-3, Vitamin D) as Medicine for Rheumatoid Arthritis – June 2017 21 Jun, 2017
Breast cancer cells killed synergistically by Vitamin D plus Omega-3 (lab) – June 2017 20 Jun, 2017
Hypothesis – anticancer benefits from synergy of omega-3 and vitamin D – May 2011 20 Jun, 2017
Vitamin D monotherapy is good, Vitamin D multitherapy is great 31 May, 2017
Health benefits of seafood: Vitamin D, Omega-3, and Selenium – Jan 2013 26 May, 2017
Cardiovascular diseases – conflicting data on benefits of Omega-3 and vitamin D – Feb 2014 24 May, 2017
Cataracts associated with low Omega-3, Vitamin D, etc – April 2017 16 May, 2017
Type 2 Diabetes helped by Omega-3 and Vitamin D – Feb 2014 03 Jan, 2017
Typical pregnancy is now 39 weeks – Omega-3 and Vitamin D might restore it to full 40 weeks 16 Oct, 2016
Alzheimer’s and Vitamins D, B, C, E, as well as Omega-3, metals, etc. – June 2013 13 Oct, 2016
Traumatic brain injury treated by Vitamin D Progesterone Omega-3 and glutamine – May 2013 11 Sep, 2016
How much vitamin D and other nutrients do I take 11 Jun, 2016
Autism risks include chemicals, deficiency of vitamin D, Omega-3 – mini-review April 2016 10 May, 2016
Kidney failure – still debating what form of vitamin D to use – April 2016 28 Apr, 2016
Sickle Cell children need more than 7,000 IU of vitamin D daily – May 2015 06 Apr, 2016
10 Diseases associated with Multiple Sclerosis are also associated with low Omega-3 and vitamin D – Feb 2016 13 Mar, 2016
Popular supplements 1 Vitamin D, 2 fish oil, 3 CoQ10, 4 multivitamins 5 probiotics - Feb 2016 27 Feb, 2016
Vitamin and Mineral deficiencies – Ames Triage Theory Sept 2012 25 Feb, 2016
Vitamin D, DHA, Folic, Iodine benefits during pregnancy – July 2012 14 Oct, 2015
If you add Omega-3, also add Vitamin E to protect it – Aug 2015 24 Aug, 2015
Omega-3, Vitamin D, and other nutrients decrease mental health problems – March 2015 11 Aug, 2015
Cognitively impaired brain atrophy was slowed 40 percent by Omega-3 and B vitamins – RCT July 2015 14 Jul, 2015
Vitamin D and Omega-3 may reduce cortical atrophy with age – Nov 2013 14 Jul, 2015
Vitamin D, Omega-3 supplementation helps cognition – perhaps due to serotonin – Feb 2015 01 Jun, 2015
Cardiovascular system benefits from both Omega-3 and vitamin D – Dec 2012 14 May, 2015
Fractures reduced 30 percent by Omega-3 (Omega-3 activates vitamin D) – May 2015 13 May, 2015
Supplements survey: Fish oil 1st, Vitamin D 4th, Magnesium 6th, Calcium 7th - March 2015 01 Mar, 2015
Longer time to fall to sleep in winter unless eat salmon (vitamin D and Omega-3) – May 2014 11 Feb, 2015
Salmon intervention (vitamin D and Omega-3) improved heart rate variability and reduced anxiety – Nov 2014 11 Feb, 2015
Vitamin D and Omega-3 are the first focus of Global Nutrition and Health Alliance 18 Sep, 2014
Unsaturated Fatty acids important for both MS and Vitamin D – Oct 2012 24 Nov, 2012
Vitamin D and omega-3 are the only supplements which show benefit in meta-analysis – Jan 2012 24 Nov, 2012
Vitamin D Omega 3 and Exercise are being used in controlled trial to support healthy ageing – Feb 2012 24 Nov, 2012
US supplements survey – 34 percent take omega-3, 30 percent take vitamin D – Aug 2012 24 Nov, 2012

Magnesium also increases Vitamin D

Omega-3 increases Vitamin D levels – Meta-analysis May 2022        
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