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Vitamin D is needed before, during and after Pregnancy – May 2022

Vitamin D: Before, during and after Pregnancy: Effect on Neonates and Children

Nutrients 2022, 14(9), 1900; https://doi.org/10.3390/nu14091900
by José Luis Mansur 1,*ORCID,Beatriz Oliveri 2,Evangelina Giacoia 3ORCID, David Fusaro 4 and Pablo René Costanzo 5,*ORCID

PDF Table of contents


A worldwide high prevalence of vitamin D (VD) deficiency has become of growing concern because of potential adverse effects on human health, including pregnant women and their offsprings. Beyond its classical function as a regulator of calcium and phosphate metabolism, together with its fundamental role in bone health in every stage of life, its deficiency has been associated to multiple adverse health effects. The classic effects of VD deficiency in pregnancy and neonates have been late hypocalcemia and nutritional rickets. Nevertheless, recent studies have linked VD to fertility and 25(OH)D with several clinical conditions in pregnancy: preeclampsia, gestational diabetes, higher incidence of cesarean section and preterm birth, while in infants, the clinical conditions are low birth weight, lower bone mass and possible relationship with the development of such diseases as bronchiolitis, asthma, type 1 diabetes, multiple sclerosis and autism included as VD non-classical actions. The supplementation with Vitamin D and achievement of optimal levels reduce maternal-fetal and newborn complications. Supplementation in children with VD deficiency reduces the risk of respiratory infections and possibly autoimmune diseases and autism. This review emphasizes the roles of Vitamin D deficiency and the consequences of intervention from preconception to infancy.
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  • 1. Bikle, D.D. Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level. J. Endocr. Soc. 2020, 4, bvz038. [CrossRef] [PubMed]
  • 2. Bouillon, R.; Marcocci, C.; Geent, C.; Bikle, D.; Blanco, J.H.; Dawson-Hughes, B.; Pablo, L.D.; Munns, C.F.; Lazaretti Castro, M.; Giustina, A.; et al. Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions. Endocr. Rev. 2019, 40,1109-1151. [CrossRef] [PubMed]
  • 3. Kiely, M.E.; Wagner, C.L.; Roth, D.E. Vitamin D in pregnancy: Where we are and where we should go. J. Steroid. Biochem. Mol. Biol. 2020, 201,105669. [CrossRef]
  • 4. Rosen, C.J.; Abrams, S.A.; Aloia, J.F.; Brannon, P.M.; Clinton, S.K.; Durazo-Arvizu, R.A.; Gallagher, J.C.; Gallo, R.L.; Jones, G.; Kovacs, C.S.; et al. IOM Committee members respond to Endocrine Society Vitamin D Guideline. J. Clin. Endocrinol. Metab. 2012, 97,1146-1152. [CrossRef] [PubMed]
  • 5. Holick, M.F.; Binkley, N.C.; Bischoff-Ferrari, H.A.; Gordon, C.M.; Hanley, D.A.; Heaney, R.P.; Murad, M.H.; Weaver, C.M. Endocrine Society. Evaluation, treatment, and prevention of Vitamin D deficiency: An Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 2011, 96,1911-1930. [CrossRef] [PubMed]
  • 6. Xiao, J.P.; Zang, J.; Pei, J.J.; Xu, F.; Zhu, Y.; Liao, X.P. Low maternal Vitamin D status during the second trimester of pregnancy: A cross-sectional study in Wuxi, China. PLoS ONE 2015,10, e0117748. [CrossRef]
  • 7. Karras, S.; Paschou, S.A.; Kandaraki, E.; Anagnostis, P.; Annweiler, C.; Tarlatzis, B.C.; Hollis, B.W.; Grant, W.B.; Goulis, D.G. Hypovitaminosis D in pregnancy in the Mediterranean region: A systematic review. Eur. J. Clin. Nutr. 2016, 70, 979-986. [CrossRef]
  • 8. Lundqvist, A.; Sandstrom, H.; Stenlund, H.; Johansson, I.; Hultdin, J. Vitamin D status during pregnancy: A longitudinal study in Swedish women from early pregnancy to seven months postpartum. PLoS ONE 2016, 3, e0150385. [CrossRef]
  • 9. Hamilton, S.A.; McNeil, R.; Hollis, B.W.; Davis, D.J.; Winkler, J.; Cook, C.; Warner, G.; Bivens, B.; McShane, P.; Wagner, C.L. Profound Vitamin D deficiency in a diverse group of women during pregnancy living in a such-rich environment at latitude 32 degree. Int. J. Endocrinol. 2010,2010, 917428. [CrossRef]
  • 10. Giacoia, E.G.; Costanzo, P.R.; Mansur, J.L. Variación estacional de los niveles de vitamina D y su relación con la obesidad en una población de embarazadas de alto riesgo en Buenos Aires. Rev. Arg. Endocrinol. Metab. 2019, 56, 31-40.
  • 11. Ortigosa Gómez, S.; García-Algar, O.; Mur Sierra, A.; Ferrer Costa, R.; Carrascosa Lezcano, A.; Yeste Fernandez, D. Concentraciones palsmáticas de 25-OH vitamina D y paratohormona en sangre de cordón umbilical. Rev. Esp. Salud Pública 2015, 89, 75-83. [CrossRef] [PubMed]
  • 12. Dawodu, A.; Wagner, C.L. Prevention of Vitamin D deficiency in mothers and infants worldwide—A paradigm shift. Paediatr. Int. Child Health 2012, 32, 3-13. [CrossRef] [PubMed]
  • 13. Liu, P.T.; Stenger, S.; Li, H.; Wenzel, L.; Tan, H.B.; Krytzik, S.R.; Ochoa, M.T.; Schauber, J.; Wu, K.; Meinken, C.; et al. Toll-like receptor triggering of a Vitamin D-mediated human antimicrobial response. Science 2006, 311,1770-1773. [CrossRef] [PubMed]
  • 14. Wagner, C.L.; Hollis, B.W. The implications of Vitamin D status during pregnancy on mother and her developing child. Front. Endocrinol. 2018, 9, 500. [CrossRef]
  • 15. Wolsk, H.M.; Chawes, B.L.; Litonjua, A.A.; Hollis, B.W.; Waage, J.; Stokholm, J.; B0nnelykke, K.; Bisgaard, H.; Weiss, S.T. Prenatal Vitamin D supplementation reduces risk of asthma/recurrent wheeze in early childhood: A combined analysis of two randomized controlled trials. PLoS ONE 2017,12, e0186657. [CrossRef]
  • 16. Brehm, J.M.; Celedon, J.C.; Soto-Quiros, M.E.; Avila, L.; Hunninghake, G.M.; Forno, E.; Laskey, D.; Sylvia, J.S.; Hollis, B.W.; Weiss, S.T.; et al. Serum Vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am. J. Respir. Critic. Care Med. 2009, 179, 765-771. [CrossRef]
  • 17. Infante, M.; Ricordi, C.; Sanchez, J.; Clare-Salzler, M.J.; Padilla, N.; Fuenmayor, V.; Chavez, C.; Alvarez, A.; Baidal, D.; Alejandro, R.; et al. Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes. Nutrients 2019, 9, 2185. [CrossRef]
  • 18. Pierrot-Deseilligny, C.; Souberbielle, J.C. Vitamin D and multiple sclerosis: An update. Mult. Scler. Relat. Disord. 2017,14, 35-45. [CrossRef]
  • 19. Oliveri, B.; Mautalen, C.; Alonso, A.; Velázquez, H.; Trouchot, H.A.; Porto, R.; Martinez, L.; Barata, A.D. Estado nutricional de vitamina D en madres y neonatos de Ushuaia y Buenos Aires. Medicina 1993, 53, 315-320.
  • 20. Bowyer, L.; Catling-Paull, C.; Diamond, T.; Homer, C.; Davis, G.; Craig, M.E. Vitamin D, PTH and calcium levels in pregnant women and their neonates. Clin. Endocrinol. 2009, 70, 372-377. [CrossRef]
  • 21. Johnson, D.D.; Wagner, C.L.; Husley, T.C.; McNeil, R.B.; Ebeling, M.; Hollis, B.W. Vitamin D deficiency and insufficiency is common during pregnancy. Am. J. Perinatol. 2011, 28, 7-12. [CrossRef] [PubMed]
  • 22. Javaid, M.K.; Crozier, S.R.; Harvey, N.C.; Gale, C.R.; Dennison, E.M.; Boucher, B.J.; Arden, N.K.; Godfrey, K.M.; Cooper, C. Maternal Vitamin D status during pregnancy and childhood bone mass at age 9 years: A longitudinal study. Lancet 2006, 367, 36-43. [CrossRef]
  • 23. Ginde, A.A.; Sullivan, A.F.; Mansbach, J.M.; Camargo, C.A., Jr. Vitamin D insufficiency in pregnant and nonpregnant women of childbearing age in the United States. Am. J. Obstet. Gynecol. 2010, 202, 436.e1-436.e8. [CrossRef] [PubMed]
  • 24. Tau, C.; Bonifacino, M.M.; Scaiola, E.; Farenga, M.; Acuña, M.; Mazzeo, M.; Córdoba, M.; Peralta, D.; Salazar, G. Niveles circulantes de 25 hidroxivitamina D en población materno-infantil de zonas de riesgo del país: Provincias de Chubut, Santa Cruz y Tierra del Fuego. Med. Infant. 2004, XI, 199-204.
  • 25. Lerchbaum, E.; Obermayer-Pietsch, B. Vitamin D and fertility: A systematic review. Eur. J. Endocrinol. 2012, 166, 765-778. [CrossRef] [PubMed]
  • 26. Blomberg Jensen, M.; Nielsen, J.E.; Jogensen, A.; Rajperts-De Meyts, E.; Krinstensen, D.M.; Jorgensen, N.; Skakkebaek, N.E.; Juul, A.; Leffers, H. Vitamin D receptor and Vitamin D metabolizing enzymes are expressed in the human male reproductive tract. Hum. Reprod. 2010,25,1303-1311. [CrossRef] [PubMed]
  • 27. Aquila, S.; Guido, C.; Middea, E.; Perrotta, I.; Bruno, S.; Pellegrino, M.; Andó, S. Human male gamete endocrinology: 1 alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates different aspects of human sperm biology and metabolism. Reprod. Biol. Endocrinol. 2009, 7,140-152. [CrossRef]
  • 28. Costanzo, P.R.; Elias, N.O.; Kleiman Rubinsztein, J.; García Basavilbaso, N.X.; Piacentini, R.; Salerni, H.H. Variaciones estacionales de 25 (OH) vitamina D en jóvenes sanos y su asociación con la radiación ultravioleta en Buenos Aires. Medicina 2011, 71, 336-342.
  • 29. Voulgaris, N.; Papanastasiou, L.; Piaditis, G.; Angelousi, A.; Kaltsas, G.; Mastorakos, G.; Kassi, E. Vitamin D and aspects of female fertility. Hormones 2017,16, 5-21.
  • 30. Arslan, S.; Akdevelioglu, Y. The relationship between female reproductive functions and Vitamin D. J. Am. Coll. Nutr. 2018, 37, 546-551. [CrossRef]
  • 31. Merhi, Z.; Doswell, A.; Krebs, K.; Cipolla, M. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. J. Clin. Endocrinol. Metab. 2014, 99,1137-1145. [CrossRef] [PubMed]
  • 32. Jukic, A.M.Z.; Baird, D.D.; Wilcox, A.J.; Weinberg, C.R.; Steiner, A.Z. 25-hydroxiVitamin D (25(OH)D) and biomarkers of ovarian reserve. Menopause 2018, 25, 811-816. [CrossRef] [PubMed]
  • 33. Pereira, N. Revisting the relationship between Vitamin D and ovarian reserve. Fertil. Steril. 2018,110, 643. [CrossRef] [PubMed]
  • 34. Dennis, N.A.; Houghton, L.A.; Pankhurst, M.W.; Harper, M.J.; McLennan, I.S. Acute supplementation with high dose Vitamin D3 increases serum Anti-Müllerian hormone in young women. Nutrients 2017, 9, 719. [CrossRef] [PubMed]
  • 35. Bednarska-Czerwinska, A.; Olszak-Wasik, K.; Olejek, A.; Czerwinski, M.; Tukiendorf, A.A. Vitamin D and Anti-Mullerian Hormone levels in infertility treatment: The change-point problem. Nutrients 2019,11,1053. [CrossRef]
  • 36. Harris, H.R.; Chavarro, J.E.; Malspeis, S.; Willett, W.C.; Missmer, S.A. Dairy-food, calcium, magnesium, and Vitamin D intake and endometriosis: A prospective cohort study. Am. J. Epidemiol. 2013,177, 420-430. [CrossRef]
  • 37. Cermisoni, G.C.; Alteri, A.; Corti, L.; Rabellotti, E.; Papaleo, E.; Vigano, P.; Sanchez, A.M. Vitamin D and endometrium: A systematic review or a neglected area of research. Int. J. Mol. Sci. 2018,19, 2320. [CrossRef]
  • 38. Fung, J.L.; Hartman, T.J.; Schleicher, R.L.; Goldman, M.B. Association of Vitamin D intake and serum levels with fertility: Results from the Lifestyle and Fertility Study. Fertil. Steril. 2017,108, 302-311. [CrossRef]
  • 39. Ozkan, S.; Jindal, S.; Greenseid, K.; Shu, J.; Zeitlian, G.; Hickmon, C.; Pal, L. Replete vitamina D stores predict reproductive success following in vitro fertilization. Fertil. Steril. 2010, 94,1314-1319. [CrossRef]
  • 40. Paffoni, A.; Ferrari, S.; Vigano, P.; Pagliardini, L.; Papaleo, E.; Candiani, M.; Tirelli, A.; Fedele, L.; Somigliana, E. Vitamin D deficiency and infertility: Insights from in vitro fertilization cycles. J. Clin. Endocrinol. Metab. 2014, 99, 2372-2376. [CrossRef]
  • 41. Farzadi, L.; Khayatzadeh Bidgoli, H.; Ghojazadeh, M.; Bahrami, Z.; Fattahi, A.; Latifi, Z.; Shahnazi, V.; Nouri, M. Correlation between follicular fluid 25-OH Vitamin D and assisted reproductive outcomes. Iran J. Reprod. Med. 2015,13, 361-366. [PubMed]
  • 42. Rudick, B.J.; Ingles, S.A.; Chung, K.; Stanczyk, F.Z.; Paulson, R.J.; Bendikson, K.A. Influence of Vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertil. Steril. 2014,101, 447-452. [CrossRef]
  • 43. Chu, J.; Gallos, I.; Tobias, A.; Tan, B.; Eapen, A.; Coomarasamy, A. Vitamin D and assisted reproductive treatment outocome: A systematic review and meta-analysis. Hum. Reprod. 2018, 33, 65-80. [CrossRef] [PubMed]
  • 44. Vanni, V.S.; Vigano, P.; Somigliana, E.; Papaleo, E.; Paffoni, A.; Pagliardini, L.; Candiani, M. Vitamin D and assisted reproduction technologies: Current concepts. Reprod. Biol. Endocrinol. 2014,12, 47. [CrossRef] [PubMed]
  • 45. Lv, S.S.; Wang, J.Y.; Wang, X.Q.; Wang, Y.; Xu, Y. Serum Vitamin D status and in vitro fertilization outcomes: A systematic review and meta-analysis. Arch. Gynecol. Obstet. 2016, 293,1339-1345. [CrossRef]
  • 46. Abedi, S.; Taebi, M.; Nasr Esfahani, M.H. Effect of Vitamin D supplementation on intracytoplasmatic sperm injection outcomes: A randomized doubled-blind placebo-controlled trial. Int. J. Fertil. Steril. 2019,13,18-23.
  • 47. Souza, J.P.; Gülmezoglu, A.M.; Vogel, J.; Carroli, G.; Lumbiganon, P.; Qureshi, Z.; Costa, M.J.; Fawole, B.; Mugerwa, Y.; Nafiou, I.; et al. Moving beyond essential interventions for reduction of maternal mortality (the WHO Multicountry Survey on Maternal and Newborn Health): A cross-sectional study. Lancet 2013, 381,1747-1755. [CrossRef]
  • 48. Mol, B.W.J.; Roberts, C.T.; Thangaratinam, S.; Magee, L.A.; de Groot, C.J.M.; Hofmeyr, G.J. Pre-eclampsia. Lancet 2016, 387, 999-1011. [CrossRef]
  • 49. Sibai, B.; Dekker, G.; Kupferminc, M. Pre-eclampsia. Lancet 2005, 365, 785-799. [CrossRef]
  • 50. Gifford, R.W.; August, P.A.; Cunningham, G.; Green, L.A.; Lindheimer, M.D.; McNellis, D.; Roberts, J.M.; Sibai, B.M.; Taler, S.J. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am. J. Obstet. Gynecol. 2000,183, S1-S22.
  • 51. Li, Y.C. Vitamin D regulation of the renin-angiotensin system. J. Cell. Biochem. 2003, 88, 327-331. [CrossRef] [PubMed]
  • 52. Li, Y.C.; Kong, J.; Wei, M.; Chen, Z.F.; Liu, S.Q.; Cao, L.P. 1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the reninangiotensin system. J. Clin. Investig. 2002,110, 229-238. [CrossRef] [PubMed]
  • 53. Dinca, M.; Serban, M.C.; Sahebkar, A.; Mikhailidis, D.P.; Toth, P.P.; Martin, S.S.; Blaha, M.J.; Blüher, M.; Gurban, C.; Penson, P.; et al. Does Vitamin D supplementation alter plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials. Pharmacol. Res. 2016,107, 360-371. [CrossRef] [PubMed]
  • 54. Cardús, A.; Parisi, E.; Gallego, C.; Aldea, M.; Fernández, E.; Valdivielso, J.M. 1,25-Dihydroxyvitamin D3 stimulates vascular smooth muscle cell proliferation through a VEGF-mediated pathway. Kidney Int. 2006, 69,1377-1384. [CrossRef]
  • 55. Evans, K.N.; Bulmer, J.N.; Kilby, M.D.; Hewison, M. Vitamin D and placental-decidual function. J. Soc. Gynecol. Investig. 2004,11, 263-271. [CrossRef]
  • 56. Lechtermann, C.; Hauffa, B.P.; Herrmann, R.; Schündeln, M.M.; Gellhaus, A.; Schmidt, M.; Grasemann, C. Maternal Vitamin D status in preeclampsia: Seasonal changes are not influenced by placental gene expression of Vitamin D metabolizing enzymes. PLoS ONE 2014, 9, e105558. [CrossRef]
  • 57. Ma, R.; Gu, Y.; Zhao, S.; Sun, J.; Groome, L.J.; Wang, Y. Expressions of Vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies. Am. J. Physiol. Endocrinol. Metab. 2012, 303, 928-935. [CrossRef]
  • 58. Bodnar, L.M.; Catov, J.M.; Simhan, H.N.; Holick, M.F.; Powers, R.W.; Roberts, J.M. Maternal Vitamin D deficiency increases the risk of preeclampsia. J. Clin. Endocrinol. Metab. 2007, 92, 3517-3522. [CrossRef]
  • 59. Tabesh, M.; Salehi-Abargouei, A.; Tabesh, M.; Esmaillzadeh, A. Maternal Vitamin D status and risk of pre-eclampsia: A systematic review and meta-analysis. J. Clin. Endocrinol. Metab. 2013, 98, 3165-3173. [CrossRef]
  • 60. Akbari, S.; Khodadadi, B.; Ahmadi, S.A.Y.; Abbaszadeh, S.; Shahsavar, F. Association of Vitamin D level and Vitamin D deficiency with risk of preeclampsia: A systematic review and updated meta-analysis. Taiwan J. Obstet. Gynecol. 2018,57, 241-247. [CrossRef]
  • 61. Zhao, X.; Fang, R.; Yu, R.; Chen, D.; Zhao, J.; Xiao, J. Maternal Vitamin D Status in the Late Second Trimester and the Risk of Severe Preeclampsia in Southeastern China. Nutrients 2017, 9,138. [CrossRef] [PubMed]
  • 62. Palacios, C.; Kostiuk, L.K.; Peña-Rosas, J.P. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst. Rev.2019, 7, CD008873. [CrossRef] [PubMed]
  • 63. Asemi, Z.; Samimi, M.; Tabassi, Z.; Shakeri, H.; Esmaillzadeh, A. Vitamin D supplementation affects serum high-sensitivity C-reactive protein, insulin resistance, and biomarkers of oxidative stress in pregnant women. J. Nutr. 2013, 143, 1432-1438. [CrossRef] [PubMed]
  • 64. Naghshineh, E.; Sheikhaliyan, S. Effect of Vitamin D supplementation in the reduce risk of preeclampsia in nulliparous women. Adv. Biomed. Res. 2016, 29, 5-7.
  • 65. Sablok, A.; Batra, A.; Thariani, K.; Batra, A.; Bharti, R.; Aggarwal, A.R.; Kabi, B.C.; Chellani, H. Supplementation of Vitamin D in pregnancy and its correlation with feto-maternal outcome. Clin. Endocrinol. 2015, 83, 536-541. [CrossRef] [PubMed]
  • 66. Sasan, S.B.; Zandvakili, F.; Soufizadeh, N.; Baybordi, E. The effects of Vitamin D supplement on prevention of recurrenceof preeclampsia in pregnant women with a history of preeclampsia. Obstet. Gynecol. Int. 2017,2017, 8249264.
  • 67. Fogacci, S.; Fogacci, F.; Banach, M.; Michos, M.; Hernandez, A.; Lip, G.; Blaha, M.; Toht, P.; Borghi, C.; Cicero, A.; et al. Vitamin D supplementation and incident preeclampsia: A systematic review and meta-analysis of randomized clinical trials. Clin. Nutr. 2020, 39,1742-1752. [CrossRef]
  • 68. Hollis, B.W.; Johnson, D.; Hulsey, T.C.; Ebeling, M.; Wagner, C.L. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. J. Bone Miner. Res. 2011, 26, 2341-2357. [CrossRef]
  • 69. Hollis, B.W.; Wagner, C.L. Vitamin D and pregnancy: Skeletal effects, nonskeletal effects, and birth outcomes. Calcif. Tissue Int. 2013, 92,128-139. [CrossRef]
  • 70. Hollis, B.W.; Wagner, C.L. New insights into the Vitamin D requirements during pregnancy. Bone Res. 2017, 5,17030. [CrossRef]
  • 71. Wagner, C.L.; Hollis, B.W.; Kotsa, K.; Fakhoury, H.; Karras, S.N. Vitamin D administration during pregnancy as prevention for pregnancy, neonatal and postnatal complications. Rev. Endocr. Metab. Disord. 2017,18, 307-322. [CrossRef] [PubMed]
  • 72. Sadeghian, M.; Asadi, M.; Rahmani, S.; Akhavan Zanjani, M.; Sadeghi, O.; Hosseini, S.A.; Zare Javid, A. Circulating Vitamin D and the risk of gestational diabetes: A systematic review and dose-response meta-analysis. Endocrine 2020, 70, 36-47. [CrossRef] [PubMed]
  • 73. Milajerdi, A.; Abbasi, F.; Mousavi, S.M.; Esmaillzadeh, A. Maternal Vitamin D status and risk of gestational diabetes mellitus: A systematic review and meta-analysis of prospective cohort studies. Clin. Nutr. 2021, 40, 2576-2586. [CrossRef] [PubMed]
  • 74. Wang, M.; Chen, Z.; Hu, Y.; Wang, Y.; Wu, Y.; Lian, F.; Li, H.; Yang, J.; Xu, X. The effects of Vitamin D supplementation on glycemic control and maternal-neonatal outcomes in women with established gestational diabetes mellitus: A systematic review and meta-analysis. Clin. Nutr. 2021, 40, 3148-3157. [CrossRef] [PubMed]
  • 75. Norman, A.W.; Frankel, J.B.; Heldt, A.M.; Grodsky, G.M. Vitamin D deficiency inhibits pancreatic secretion of insulin. Science 1980, 209, 823-825. [CrossRef]
  • 76. Alvarez, J.A.; Ashraf, A. Role of Vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis. Int. J. Endocrinol. 2010, 2010, 351385. [CrossRef]
  • 77. Loy, S.L.; Lek, N.; Yap, F.; Soh, S.E.; Padmapriya, N.; Tan, K.H.; Biswas, A.; Yeo, G.S.; Kwek, K.; Gluckman, P.D.; et al. Association of Maternal Vitamin D Status with Glucose Tolerance and Caesarean Section in a Multi-Ethnic Asian Cohort: The Growing Up in Singapore Towards Healthy Outcomes Study. PLoS ONE 2015,10, e0142239. [CrossRef]
  • 78. Ward, K.A.; Das, G.; Berry, J.L.; Roberts, S.A.; Rawer, R.; Adams, J.E.; Mughal, Z. Vitamin D status and muscle function in post-menarchal adolescent girls. J. Clin. Endocrinol. Metab. 2009, 94, 559-563. [CrossRef]
  • 79. Foo, L.H.; Zhang, Q.; Zhu, K.; Ma, G.; Hu, X.; Greenfield, H.; Fraser, D.R. Low Vitamin D status has an adverse influence on bone mass, bone turnover, and muscle strength in Chinese adolescent girls. J. Nutr. 2009,139,1002-1007. [CrossRef]
  • 80. Badalian, S.S.; Rosenbaum, P.F. Vitamin D and pelvic floor disorders in women: Results from the National Health and Nutrition Examination Survey. Obstet. Gynecol. 2010,115,795-803. [CrossRef]
  • 81. Hay-Smith, J.; Morkved, S.; Fairbrother, K.A.; Herbison, G.P. Pelvic floor muscle training for prevention and treatment of urinary and faecal incontinence in antenatal and postnatal women. Cochrane Database Syst. Rev. 2008, 8, CD007471.
  • 82. Salvesen, K.A.; Morkved, S. Randomised controlled trial of pelvic floor muscle training during pregnancy. BMJ. 2004, 329, 378-380. [CrossRef] [PubMed]
  • 83. Merewood, A.; Mehta, S.D.; Chen, T.C.; Bauchner, H.; Holick, M.F. Association between Vitamin D deficiency and primary cesarean section. J. Clin. Endocrinol. Metab. 2009, 94, 940-955. [CrossRef] [PubMed]
  • 84. Gallo, S.; McDermid, J.M.; Al-Nimr, R.I.; Hakeem, R.; Moreschi, J.M.; Pari-Keener, M.; Stahnke, B.; Papoutsakis, C.; Handu, D.; Cheng, F.W. Vitamin D Supplementation during Pregnancy: An Evidence Analysis Center Systematic Review and Meta-Analysis. J. Acad. Nutr. Diet 2020,120, 898-924. [CrossRef]
  • 85. Bialy, L.; Fenton, T.; Shulhan-Kilroy, J.; Johnson, D.W.; McNeil, D.A.; Hartling, L. Vitamin D supplementation to improve pregnancy and perinatal outcomes: An overview of 42 systematic reviews. BMJ. Open 2020,10, e032626. [CrossRef]
  • 86. Eggel-Hort, B.; Maisonneuve, E.; Gonzalez Rodriguez, E.; Baud, D. Vitamine D et grossesse [Vitamin D and pregnancy]. Rev. Med. Suisse 2021,17,1774-1778.
  • 87. Miliku, K.; Vinkhuyzen, A.; Blanken, L.M.; McGrath, J.J.; Eyles, D.W.; Burne, T.H.; Hofman, A.; Tiemeier, H.; Steegers, E.A.; Gaillard, R.; et al. Maternal Vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes. Am. J. Clin. Nutr. 2016,103,1514-1522. [CrossRef]
  • 88. Gernand, A.D.; Simhan, H.N.; Baca, K.M.; Caritis, S.; Bodnar, L.M. Vitamin D, pre-eclampsia, and preterm birth among pregnancies at high risk for pre-eclampsia: An analysis of data from a low-dose aspirin trial. BJOG 2017, 124, 1874-1882. [CrossRef]
  • 89. Mojibian, M.; Soheilykhah, S.; Fallah Zadeh, M.A.; Jannati Moghadam, M. The effects of Vitamin D supplementation on maternal and neonatal outcome: A randomized clinical trial. Iran J. Reprod. Med. 2015,13, 687-696.
  • 90. Hossain, N.; Kanani, F.H.; Ramzan, S.; Kausar, R.; Ayaz, S.; Khanani, R.; Pal, L. Obstetric and neonatal outcomes of maternal Vitamin D supplementation: Results of an openlabel, randomized controlled trial of antenatal Vitamin D supplementation in Pakistani women. J. Clin. Endocrinol. Metab. 2014, 99, 2448-2455. [CrossRef]
  • 91. Singh, J.; Hariharan, C.; Bhaumik, D. Role of Vitamin D in reducing the risk of preterm labour. Int. J. Reprod. Contracep. Obstet. Gynecol. 2015, 4, 80-86. [CrossRef]
  • 92. Dutra, L.V.; Affonso-Kaufman, F.A.; Cafeo, F.R.; Kassai, M.S.; Barbosa, C.P.; Santos Figueiredo, F.W.; Suano-Souza, F.I.; Bianco, B. Association between Vitamin D plasma concentrations and VDR gene variants and the risk of premature birth. BMC. Pregnancy Childbirth 2019,20, 3. [CrossRef]
  • 93. Ryan, B.A.; Kovacs, C.S. Calciotropic and phosphotropic hormones in fetal and neonatal bone development. Semin. Fetal Neonatal Med. 2020,25,101062. [CrossRef] [PubMed]
  • 94. Belkacemi, L.; Bedard, I.; Simoneau, L.; Lafond, J. Calcium channels, transporters and exchangers in placenta: A review. Cell. Calcium 2005, 37,1-8. [CrossRef]
  • 95. Martin, R.; Harvey, N.C.; Crozier, S.R.; Poole, J.R.; Javaid, M.K.; Dennison, E.M.; Inskip, H.M.; Hanson, M.; Godfrey, K.M.; Cooper, C.; et al. Placental calcium transporter (PMCA3) gene expression predicts intrauterine bone mineral accrual. Bone 2007, 40, 1203-1208. [CrossRef]
  • 96. Kip, S.N.; Strehler, E.E. Vitamin D3 upregulates plasma membrane Ca2+-ATPase expression and potentiates apico-basal Ca2+ flux in MDCK cells. Am. J. Physiol. Ren. Physiol. 2004,286, F363-F369. [CrossRef] [PubMed]
  • 97. Namgung, R.; Tsang, R.C. Factors affecting newborn bone mineral content: In utero effects on newborn bone mineralization. Proc. Nutr. Soc. 2000, 59, 55-63. [CrossRef] [PubMed]
  • 98. Harvey, N.C.; Javaid, M.K.; Poole, J.R.; Taylor, P.; Robinson, S.M.; Inskip, H.M.; Godfrey, K.M.; Cooper, C.; Dennison, E.M.; Southampton Women's Survey Study Group. Paternal skeletal size predicts intrauterine bone mineral accrual. J. Clin. Endocrinol. Metab. 2008, 93,1676-1681. [CrossRef]
  • 99. Ioannou, C.; Javaid, M.K.; Mahon, P.; Yaqub, M.-K.; Harvey, N.C.; Godfrey, K.M.; Noble, J.A.; Cooper, C.; Papageorghiou, A.T. The effect of maternal Vitamin D concentration on fetal bone. J. Clin. Endocrinol. Metab 2012, 97, E2070-E2077. [CrossRef]
  • 100. Viljakainen, H.T.; Korhonen, T.; Hytinantti, T.; Laitinen, E.K.A.; Andersson, S.; Makitie, O.; Lamberg-Allard, C. Maternal Vitamin D status affects bone growth in early childhood—A prospective cohort study. Osteoporos. Int. 2011, 22, 883-891. [CrossRef]
  • 101. Weiler, H.; Fitzpatrick-Wong, S.; Veitch, R.; Kovacs, H.; Schellenberg, J.; McCloy, U.; Yuen, C.K. Vitamin D deficiency and whole-body and femur bone mass relative to weight in healthy newborns. CMAJ 2005,172, 757-761. [CrossRef] [PubMed]
  • 102. Akcakus, M.; Koklu, E.; Budak, N.; Kula, M.; Kurtoglu, S.; Koklu, S. The relationship between birthweight, 25-hydroxyvitamin D concentrations and bone mineral status in neonates. Ann. Trop. Paediatr. 2006,26, 267-275. [CrossRef] [PubMed]
  • 103. Dror, D.K.; King, J.C.; Fung, E.B.; Van Loan, M.D.; Gertz, E.R.; Allen, L.H. Evidence of associations between feto-maternal Vitamin D status, cord parathyroid hormone and bone-specific alkaline phosphatase, and newborn whole body bone mineral content. Nutrients 2012, 4, 68-77. [CrossRef] [PubMed]
  • 104. Prentice, A.; Jarjou, L.M.; Goldberg, G.R.; Bennett, J.; Cole, T.J.; Schoenmakers, I. Maternal plasma 25-hydroxyvitamin D concentration and birthweight, growth and bone mineral accretion of Gambian infants. Acta Paediatr. 2009, 98, 360-362. [CrossRef]
  • 105. Gharibeh, N.; Razaghi, M.; Vanstone, C.A.; Wei, S.Q.; McNally, D.; Rauch, F.; Weiler, H.A.; Kaufmann, M.; Jones, G. Correlates of Neonatal Bone Mass in Healthy Term Breastfed Young Infants from Montreal, Canada. Nutrients 2021,13, 4189. [CrossRef]
  • 106. Hernandez, C.J.; Beaupre, G.S.; Carter, D.R. A theoretical analysis of the relative influences of peak BMD, age-related bone loss and menopause on the development of osteoporosis. Osteoporos. Int. 2003,14, 843-847. [CrossRef]
  • 107. Weaver, C.B.; Gordon, C.M.; Janz, K.F.; Kalkwarf, H.J.; Lappe, J.M.; Lewis, R.; O'Karma, M.; Wallace, T.C.; Zemel, B.S. The National Osteoporosis Foundation's position statement on peak bone mass development and lifestyle factors: A systematic review and implementation recommendations. Osteoporos. Int. 2016, 27,1281-1386. [CrossRef]
  • 108. Zhu, K.; Whitehouse, A.J.; Hart, P.H.; Kusel, M.; Mountain, J.; Lye, S.; Pennell, G.; Walsh, J.P. Maternal Vitamin D status during pregnancy and bone mass in offspring at 20 years of age: A prospective cohort study. J. Bone Miner. Res. 2014, 29,1088-1095. [CrossRef]
  • 109. Lawlor, D.A.; Wills, A.K.; Fraser, A.; Sayers, A.; Fraser, W.D.; Tobias, J.H. Association of maternal Vitamin D status during pregnancy with bone-mineral content in offspring: A prospective cohort study. Lancet 2013, 381, 2176-2183. [CrossRef]
  • 110. Garcia, A.H.; Erler, N.S.; Jaddoe, W.V.; Tiemeier, H.; van den Hooven, E.H.; Franco, O.H.; Rivadeneira, F.; Voortman, T. 25-hydroxyvitamin D concentrations during fetal life and bone health in children aged 6 years: A population-based prospective cohort study. Lancet Diabetes Endocrinol. 2017, 5, 367-376. [CrossRef]
  • 111. Harvey, N.C.; Javaid, K.; Bishop, N.; Kennedy, S.; Papageorghiou, A.T.; Fraser, R.; Gandhi, S.V.; Schoenmakers, I.; Prentice, A.; Cooper, C. MAVIDOS maternal Vitamin D osteoporosis study: Study protocol for a randomized controlled trial. The MAVIDOS study group. Trials 2012,13,13. [CrossRef] [PubMed]
  • 112. Cooper, C.; Harvey, N.C.; Bishop, N.J.; Kennedy, S.; Papageorghiou, A.T.; Schoenmakers, I.; Fraser, R.; Gandhi, S.V.; Carr, A.; D'Angelo, S.; et al. Maternal gestational Vitamin D supplementation and offspring bone health (MAVIDOS): A multicentre, double-blind, randomised placebo-controlled trial. Lancet Diabetes Endocrinol. 2016, 4, 393-402. [CrossRef]
  • 113. Moon, R.J.; Curtis, E.M.; Woolford, S.J.; Ashai, S.; Cooper, C.; Harvey, N.C. The importance of maternal pregnancy Vitamin D for offspring bone health: Learnings from the MAVIDOS trial. Ther. Adv. Musculoskel. Dis. 2021,13,1759720X211006979. [CrossRef] [PubMed]
  • 114. Clark, E.M.; Ness, A.R.; Bishop, N.J.; Tobias, J.H. Association between bone mass and fractures in children: A prospective cohort study. J. Bone Miner. Res. 2006, 21,1489-1495. [CrossRef]
  • 115. Brustad, N.; Garland, J.; Thorsen, J.; Sevelsted, A.; Krakauer, M.; Vinding, R.K.; Stokholm, J.; Bonnelykke, K.; Bisgaard, H.; Chawes, B.L. Effect of high-dose vs standard-dose Vitamin D supplementation in pregnancy on bone mineralization in offspring until age 6 years: A prespecified secondary analysis of a double blinded, randomized clinical trial. JAMA Pediatr. 2020, 174, 419-427. [CrossRef]
  • 116. Vaziri, F.; Dabbaghmanesh, M.H.; Samsami, A.; Nasiri, S.; Shirazi, P.T. Vitamin D supplementation during pregnancy on infant anthropometric measurements and bone mass of mother-infant pairs: A randomized placebo clinical trial. Early Hum. Dev. 2016, 103, 61-68. [CrossRef]
  • 117. Sahoo, S.K.; Katam, K.K.; Das, V.; Agarwal, A.; Bhatia, V. Maternal Vitamin D supplementation in pregnancy and offspring outcomes: A double-blind randomized placebo-controlled trial. J. Bone Miner. Metab. 2016, 35, 464-471. [CrossRef]
  • 118. Reichetzeder, C.; Chen, H.; Foller, M.; Slowinski, T.; Li, J.; Chene, Y.P.; Lang, F.; Hocher, B. Maternal Vitamin D deficiency and fetal programming—lessons learned from humans and mice. Kidney Blood Press. Res. 2014, 39, 315-329. [CrossRef]
  • 119. Curtis, E.M.; Murray, R.; Titcombe, P.; Curtis, E.M.; Murray, R.; Titcombe, P.; Cook, E.; Clarke-Harris, R.; Costello, P.; Garratt, E.; et al. Perinatal DNA methylation at CDKN2A is associated with offspring bone mass: Findings from the Southampton women's survey. J. Bone Miner. Res. 2017, 32, 2030-2040. [CrossRef]
  • 120. Harvey, N.C.; Sheppard, A.; Godfrey, K.M.; McLean, C.; Garratt, E.; Ntani, G.; Davies, L.; Murray, R.; Inskip, H.M.; Gluckman, P.D.; et al. Childhood bone mineral content is associated with methylation status of the RXRA promoter at birth. J. Bone Miner. Res. 2014, 29, 600-607. [CrossRef]
  • 121. Curtis, E.M.; Krstic, N.; Cook, E.; D'Angelo, S.; Crozier, S.R.; Moon, R.J.; Murray, R.; Garratt, E.; Costello, P.; Cleal, J.; et al. Gestational Vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: Results from the MAVIDOS trial. J. Bone Miner. Res. 2019, 34,231-240. [CrossRef] [PubMed]
  • 122. Zhou, Y.; Zhao, L.J.; Xu, X.; Ye, A.; Travers-Gustafson, D.; Zhou, B.; Wang, H.W.; Zhang, W.; Hamm, L.L.; Deng, H.W.; et al. DNA methylation levels of CYP2R1 and CYP24A1 predict Vitamin D response variation. J. Steroid Biochem. Mol. Biol. 2014,144, 207-214. [CrossRef] [PubMed]
  • 123. Suderman, M.; Stene, L.C.; Bohlin, J.; Page, C.M.; Holvik, K.; Parr, C.L.; Magnus, M.C.; Haberg, S.E.; Joubert, B.R.; Wu, M.C.; et al. 25-Hydroxyvitamin D in pregnancy and genome wide cord blood DNA methylation in two pregnancy cohorts (MoBa and ALSPAC). J. Steroid. Biochem. Mol. Biol. 2016,159,102-109. [CrossRef] [PubMed]
  • 124. Benjamin Neelon, S.E.; White, A.J.; Vidal, A.C.; Schildkraut, J.M.; Murtha, A.P.; Murphy, S.K.; Kullman, S.W.; Hoyo, C. Maternal Vitamin D, DNA methylation at imprint regulatory regions and offspring weight at birth, 1 year and 3 years. Int. J. Obes. 2018, 42, 587-593. [CrossRef] [PubMed]
  • 125. Hansdottir, S.; Monick, M.M.; Hinde, S.L.; Lovan, N.; Look, D.C.; Hunninghake, G.W. Respiratory epithelial cells convert inactive Vitamin D to its active form: Potential effects on host defense. J. Immunol. 2008,181, 7090-7099. [CrossRef]
  • 126. Belderbos, M.E.; Houben, M.L.; Wilbrink, B.; Lentjes, E.; Bloemen, E.M.; Kimpen, J.L.L.; Rovers, M.; Bont, L. Cord blood Vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Pediatrics 2011,127,1513-1520. [CrossRef]
  • 127. Mohamed, W.A.; Al-Shehri, M.A. Cord blood 25-hydroxyvitamin D levels and the risk of acute lower respiratory tract infection in early childhood. J. Trop. Pediatr. 2013, 59, 29-35. [CrossRef]
  • 128. Luczynska, A.; Logan, C.; Nieters, A.; Elgizouli, M.; Schottker, B.; Brenner, H.; Rothenbacher, D. Cord blood 25(OH)D levels and the subsequent risk of lower respiratory tract infections in early childhood: The Ulm birth cohort. Eur. J. Epidemiol. 2014, 29, 585-594. [CrossRef]
  • 129. Moreno-Solís, G.; Fernández-Gutiérrez, F.; Torres-Borrego, J.; Torcello-Gáspar, R.; Gómez-Chaparro Moreno, J.L.; Pérez-Navero, J.L. Low serum 25-hydroxyvitamin D levels and bronchiolitis severity in Spanish infants. Eur. J. Pediatr. 2015, 174, 365-372. [CrossRef]
  • 130. Golan-Tripto, I.; Loewenthal, N.; Asher, T.; Dizitzer, Y.; Baumfeld, Y.; Goldbart, A. Vitamin D deficiency in children with acute bronchiolitis: A prospective cross-sectional case- control study. BMC. Pediatr. 2021, 21, 211. [CrossRef]
  • 131. Alakas, Y.; Celiloglu, C.; Tolunay, O.; Matyar, S. The Relationship between Bronchiolitis Severity and Vitamin D Status. J. Trop. Pediatr. 2021, 67, fmab081. [CrossRef] [PubMed]
  • 132. Phuong, V.; Koppel, C.; Espinola, J.A.; Mansbach, J.M.; Celedón, J.C.; Hasegawa, K.; Bair-Merritt, M.; Camargo, C.A., Jr. Vitamin D Status at the Time of Hospitalization for Bronchiolitis and Its Association with Disease Severity. J. Pediatr. 2018, 203, 416-422.
  • 133. Khaled, S.; Nafisa, H.R.; El-Houfey, A.A.; El-Asheer, O.; Mohamed, S.A.A.; Ahmed, E.A.; Abdel Baseer, K.A.; Darwish, M.M. Trial of Vitamin D Supplementation in Infants with Bronchiolitis: A Randomized, Double-Blind, Placebo-Controlled Study. Pediatr. Allergy Immunol. Pulmonol. 2015, 28,102-106.
  • 134. Camargo, C.A., Jr.; Rifas-Shiman, S.L.; Litonjua, A.A.; Rich-Edwuards, J.W.; Weiss, S.T.; Gold, D.R.; Kleinman, K.; Gillman, M.W. Maternal intake of Vitamin D during pregnancy and risk of recurrent wheeze in children at 3 years of age. Am. J. Clin. Nutr. 2007, 85, 788-795. [CrossRef] [PubMed]
  • 135. Wolsk, H.M.; Harshfield, B.J.; Laranjo, N.; Carey, V.J.; O'Connor, G.; Sandel, M.; Strunk, R.C.; Bacharier, L.B.; Zeiger, R.S.; Schatz, M.; et al. Vitamin D supplementation in pregnancy, prenatal 25(OH)D levels, race, and subsequent asthma or recurrent wheeze in offspring: Secondary analyses from the Vitamin D Antenatal Asthma Reduction Trial. J. Allergy Clin. Immunol. 2017,140, 1423-1429. [CrossRef]
  • 136. Lu, M.; Litonjua, A.A.; O'Connor, G.T.; Zeiger, R.S.; Bacharier, L.; Schatz, M.; Carey, V.J.; Weiss, S.T.; Mirzakhani, H. Effect of early and late prenatal Vitamin D and maternal asthma status on offspring asthma or recurrent wheeze. J. Allergy Clin. Immunol. 2021, 147,1234-1241. [CrossRef]
  • 137. Grant, C.; Crane, J.; Mitchell, E.A.; Sinclair, J.; Stewart, A.; Milne, T.; Knight, J.; Gilchrist, C.; Camargo, C.A., Jr. Vitamin D supplementation during pregnancy and infancy reduces aeroallergen sensitization: A randomized controlled trial. Allergy 2016, 71,1325-1334. [CrossRef]
  • 138. Jacobsen, R.; Hypponen, E.; Sorensen, T.I.; Waag, A.A.; Heltmann, B.L. Gestational and Early Infancy Exposure to Margarine Fortified with Vitamin D through a National Danish Programme and the Risk of Type 1 Diabetes: The D-Tect Study. PLoS ONE 2015,10, e0128631. [CrossRef]
  • 139. Hyppönen, E.; Laara, E.; Reunanen, A.; Jarvelin, S.; Virtanen, S.M. Intake of Vitamin D and risk of type 1 diabetes: A birth-cohort study. Lancet 2001, 358,1500-1503. [CrossRef]
  • 140. Mäkinen, M.; Simell, V.; Mykkänen, J.; Ilonen, J.; Veijola, R.; Hyöty, H.; Knip, M.; Simell, O.; Toppari, J.; Hermann, R. An increase in serum 25-hydroxyvitamin D concentrations preceded a plateau in type 1 diabetes incidence in Finnish children. J. Clin. Endocrinol. Metab. 2014, 99, E2353-E2356. [CrossRef]
  • 141. Sorensen, I.M.; Joner, G.; Jenum, P.A.; Eskild, A.; Torjesen, P.A.; Stene, L.C. Maternal serum levels of 25-hydroxy-vitamin D during pregnancy and risk of type 1 diabetes in the offspring. Diabetes 2012, 61,175-178. [CrossRef] [PubMed]
  • 142. Miettinen, M.E.; Reinert, L.; Kinnunen, L.; Harjutsalo, V.; Koskela, P.; Surcel, H.M.; Lamberg-Allardt, C.; Tuomilehto, J. Serum 25-hydroxyvitamin D level during early pregnancy and type 1 diabetes risk in the offspring. Diabetologia 2012, 55, 1291-1294. [CrossRef] [PubMed]
  • 143. Thorsen, S.U.; Márild, K.; Olsen, S.F.; Holst, K.K.; Tapia, G.; Granström, C.; Halldorsson, T.I.; Cohen, A.S.; Haugen, M.; Lundqvist, M.; et al. Lack of Association Between Maternal or Neonatal Vitamin D Status and Risk of Childhood Type 1 Diabetes: A Scandinavian Case-Cohort Study. Am. J. Epidemiol. 2018,187,1174-1181. [CrossRef] [PubMed]
  • 144. Chun, R.F.; Lauridsen, A.L.; Suon, L.; Zella, L.A.; Wesley Pike, J.; Modlin, R.L.; Martineau, A.R.; Wilkinson, R.J.; Adams, J.; Hewison, M. Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1,25-dihydroxyvitamin D. J. Clin. Endocrinol. Metab. 2010, 95, 3368-3376. [CrossRef]
  • 145. Goodin, D.S. The epidemiology of multiple sclerosis: Insights to disease pathogenesis. Handb. Clin. Neurol. 2014,122, 231-266.
  • 146. Dobson, R.; Giovannoni, G.; Ramagopalan, S. The month of birth effect in multiple sclerosis: Systematic review, meta-analysis and effect of latitude. J. Neurol. Neurosurg. Psychiatry 2013, 84, 427-432. [CrossRef]
  • 147. Munger, K.L.; Aivo, J.; Hongell, K.; Soilu-Hanninen, M.; Surcel, H.M.; Ascherio, A. Vitamin D status during pregnancy and risk of multiple sclerosis in offspring of women in the finnish maternity cohort. JAMA Neurol. 2016, 73, 515-519. [CrossRef]
  • 148. Wang, Z.; Ding, R.; Wang, J. The Association between Vitamin D Status and Autism Spectrum Disorder (ASD): A Systematic Review and Meta-Analysis. Nutrients 2020,13, 86. [CrossRef]
  • 149. Gillberg, C.; Schaumann, H.; Gillberg, I.C. Autism in immigrants: Children born in Sweden to mothers born in Uganda. J. Intellect. Disabil. Res. 1995, 39,141-144. [CrossRef]
  • 150. Cannell, J.J. Autism and Vitamin D. Med. Hypotheses 2008, 70, 750-759. [CrossRef]
  • 151. Cannell, J.J. Vitamin D and autism, what's new? Rev. Endocr. Metab. Disord. 2017,18,183-193. [CrossRef] [PubMed]
  • 152. Fernell, E.; Bejerot, S.; Westerlund, J.; Miniscalco, C.; Simila, H.; Eyles, D.; Gillberg, C.; Humble, M.B. Autism spectrum disorder and low Vitamin D at birth: A sibling control study. Mol. Autism 2015, 6, 3. [CrossRef] [PubMed]
  • 153. Currenti, S.A. Understanding and determining the etiology of autism. Cell. Mol. Neurobiol. 2010, 30,161-171. [CrossRef] [PubMed]
  • 154. Patrick, R.P.; Ames, B.N. Vitamin D hormone regulates serotonin synthesis. Part 1: Relevance for autism. FASEB J. 2014, 28, 2398-2413. [PubMed]
  • 155. Feng, J.; Shan, L.; Du, L.; Wang, B.; Li, H.; Wang, W.; Wang, T.; Dong, H.; Yue, X.; Xu, Z.; et al. Clinical improvement following Vitamin D3 supplementation in Autism Spectrum Disorder. Nutr. Neurosci. 2017,20, 284-290. [CrossRef] [PubMed]
  • 156. Stubbs, G.; Henley, K.; Green, J. Autism: Will Vitamin D supplementation during pregnancy and early childhood reduce the recurrence rate of autism in newborn siblings? Med. Hypotheses 2016, 88, 74-78. [CrossRef] [PubMed]

VitaminDWiki - Pregnancy category contains

887 items in Pregnancy category

 - see also

VitaminDWiki - Healthy pregnancies need lots of vitamin D contains

Vit. D
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

"Vitamin D before, during, and after pregnancy" was the original name of Overview Pregnancy and vitamin D

How much Vitamin D for optimal health

Note: The study on this page say >30 ng is needed

VitaminDWiki - Optimal Vitamin D studies in Pregnancy category

This list is automatically updated

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Vitamin D is needed before, during and after Pregnancy – May 2022        
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