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More than 30 ng of vitamin D is needed for many diseases - Feb 2022


A Narrative Review of the Evidence for Variations in Serum 25-Hydroxyvitamin D Concentration Thresholds for Optimal Health

Nutrients 2022, 14,639. https:// doi.org/10.3390/nu14030639
William B. Grant h* , Fatme Al Anouti 2 , Barbara J. Boucher 3©, Erding Dursun 4©, Duygu Gezen-Ak 4©, Edward B. Jude 5,6,7 , Tatiana Karonova 8 and Pawel Pludowski 9

Vitamin D3 has many important health benefits. Unfortunately, these benefits are not widely known among health care personnel and the general public. As a result, most of the world's population has serum 25-hydroxyvitamin D (25(OH)D) concentrations far below optimal values. This narrative review examines the evidence for the major causes of death including cardiovascular disease, hypertension, cancer, type 2 diabetes mellitus, and COVID-19 with regard to sub-optimal 25(OH)D concentrations. Evidence for the beneficial effects comes from a variety of approaches including ecological and observational studies, studies of mechanisms, and Mendelian randomization studies. Although randomized controlled trials (RCTs) are generally considered the strongest form of evidence for pharmaceutical drugs, the study designs and the conduct of RCTs performed for vitamin D have mostly been flawed for the following reasons: they have been based on vitamin D dose rather than on baseline and achieved 25(OH)D concentrations; they have involved participants with 25(OH)D concentrations above the population mean; they have given low vitamin D doses; and they have permitted other sources of vitamin D. Thus, the strongest evidence generally comes from the other types of studies. The general finding is that optimal 25(OH)D concentrations to support health and wellbeing are above 30 ng/mL (75 nmol/L) for cardiovascular disease and all-cause mortality rate, whereas the thresholds for several other outcomes appear to range up to 40 or 50 ng/mL. The most efficient way to achieve these concentrations is through vitamin D supplementation. Although additional studies are warranted, raising serum 25(OH)D concentrations to optimal concentrations will result in a significant reduction in preventable illness and death.
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Grassrootshealth chart of the data
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Minimal levels needed
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VitaminDWiki - Vitamin D needed to TREAT Health problems

Vitamin D Treats
150 ng Multiple Sclerosis *
80 ng Cluster Headache *
Reduced office visits by 4X *
70 ngSleep *
60 ngBreast Cancer death reduced 60%
Preeclampsia RCT
50 ng COVID-19
Fertility
Psoriasis
Infections Review
Infection after surgery
40 ng Breast Cancer 65% lower risk
Depression
ACL recovery
Hypertension
Asthma?
30 ng Rickets

* Evolution of experiments with patients, often also need co-factors
See: Is 50 ng of vitamin D too high, just right, or not enough


VitaminDWiki - Optimum category starts

The RDA is barely enough for the bones to survive.
   Need an optimal level for the body to thrive

99 items in Optimum Vitamin D category

Example pages

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Created by admin. Last Modification: Monday November 27, 2023 03:29:52 GMT-0000 by admin. (Version 13)

Attached files

ID Name Comment Uploaded Size Downloads
20411 Optimal GRH Grant Green.png admin 27 Nov, 2023 102.46 Kb 1035
20410 Optimal GRH Grant.png admin 27 Nov, 2023 117.12 Kb 18
17029 GRH Grant Feb 2022.jpg admin 09 Feb, 2022 161.67 Kb 396
17027 Optimal levels grant.jpg admin 09 Feb, 2022 56.68 Kb 398
17026 Grant Narative.pdf admin 09 Feb, 2022 372.85 Kb 274