25-Hydroxyvitamin D Concentration is Inversely Associated with Serum MMP-9 in a cross-sectional study of African American ESRD Patients.
BMC Nephrol. 2011 May 22;12(1):24.
Wasse H, Cardarelli F, De Staercke C, Hooper C, Veledar E, Guessous I.
Circulating 25-hydroxyvitamin D [25(OH)D] concentration is inversely associated with peripheral arterial disease and hypertension. Vascular remodeling may play a role in this association, however, data relating vitamin D level to specific remodeling biomarkers among ESRD patients is sparse. We tested whether 25(OH)D concentration is associated with markers of vascular remodeling and inflammation in African American ESRD patients.
We conducted a cross-sectional study among ESRD patients receiving maintenance hemodialysis within Emory University-affiliated outpatient hemodialysis units. Demographic, clinical and dialysis treatment data were collected via direct patient interview and review of patients records at the time of enrollment, and each patient gave blood samples. Associations between 25(OH)D and biomarker concentrations were estimated in univariate analyses using Pearson's correlation coefficients and in multivariate analyses using linear regression models. 25(OH) D concentration was entered in multivariate linear regression models as a continuous variable and binary variable (<15 ng/ml and greater than or equal to 15 ng/ml). Adjusted estimate concentrations of biomarkers were compared between 25(OH) D groups using analysis of variance (ANOVA). Finally, results were stratified by vascular access type.
Among 91 patients, mean (standard deviation) 25(OH)D concentration was 18.8 (9.6) ng/ml, and was low (< 15 ng/ml) in 43% of patients. In univariate analyses, low 25(OH) D was associated with lower serum calcium, higher serum phosphorus, and higher LDL concentrations. 25(OH) D concentration was inversely correlated with MMP-9 concentration (r=-0.29, p=0.004). In multivariate analyses, MMP-9 concentration remained negatively associated with 25(OH) D concentration (P=0.03) and anti-inflammatory IL-10 concentration positively correlated with 25(OH) D concentration (P=0.04).
Plasma MMP-9 and circulating 25(OH) D concentrations are significantly and inversely associated among ESRD patients. This finding may suggest a potential mechanism by which low circulating 25(OH) D functions as a cardiovascular risk factor.
ESRD = End Stage Renal Disease
- Overview Kidney and vitamin D
- Dialysis patients with low vitamin D were 2.7 X more likely to die of heart problems – Feb 2011
- Virtually all black dialysis patients with low albumin are vitamin D deficient in the winter – Mar 2010
- Low vitamin D associated with hemodialysis problems – May 2010
- Dialysis patients who added Vitamin D were 41 percent less likely to get infection – Meta-analysis July 2018