Nutritional Vitamin D Supplementation in Dialysis: A Randomized Trial
CJASN April 07, 2015 vol. 10 no. 4 611-619
Ishir Bhan*, Dorothy Dobens*, Hector Tamez*, Joseph J. Deferio*, Yan Chun Li†, H. Shaw Warren‡, Elizabeth Ankers*, Julia Wenger*, J. Kevin Tucker*, Caitlin Trottier*, Fridosh Pathan§, Sahir Kalim*, Sagar U. Nigwekar*, Ravi Thadhani*
*Division of Nephrology, Department of Medicine,
‡Infectious Disease Unit, Departments of Pediatrics and Medicine, and
§Pharmacy Department, Massachusetts General Hospital, Boston, Massachusetts; and
†Department of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, Illinois
Dr. Ishir Bhan, Department of Medicine, Massachusetts General Hospital, 50 Staniford Street, Suite 750, Boston, MA 02114. Email: ibhan at mgh.harvard.edu
It is amazing that human doctors persist in trying to use Vitamin D2
Animal doctors (vets) agreed 10 years ago that Vitamin D2 should not be used on any mammal.
They had found too many problems with vitamin D2
Also, the activated form of vitamin D is far better for people with kidney problems
See also VitaminDWiki
Overview Vitamin D3 not D2
Search VitaminDWiki for DIALYSIS 309 items as of April 2015
Dialysis patients need real vitamin D – Editorial July 2013
Vitamin D3 instead of D2 category in VitaminDWiki starts withSome of the
- Overview Vitamin D3 not D2
- Physicians Desk Reference still only lists D2, but not Vitamin D3 – Feb 2022
- Vitamin D3 better than D2, especially if non-daily or high dose - meta-analysis Sept 2021
- It’s Time to Say “Goodbye” to Vitamin D2 - 2015
- Vitamin D2 decreases levels of D3 (again) and visa versa – RCT Jan 2019
- It’s (way past) time to stop prescribing with Vitamin D2 (ergocalciferol) – Oct 2018
- If you have a vitamin D prescription, be sure that it is for D3– June 2017
- Vitamin D reduces risk of cause specific death, unless it is D2 – meta-analysis BMJ April 2014
- Vitamin D2 should not be used as a Vitamin supplement for any mammal – Oct 2006
- Loading dose of Vitamin D2 REDUCED vitamin D blood in a third of the patients – Jan 2015
Background and objectives Vitamin D (25-hydroxyvitamin D; 25[OH]D) deficiency is common in patients initiating long-term hemodialysis, but the safety and efficacy of nutritional vitamin D supplementation in this population remain uncertain.
Design, setting, participants, & measurements This randomized, placebo-controlled, parallel-group multicenter trial compared two doses of ergocalciferol with placebo between October 2009 and March 2013. Hemodialysis patients (n=105) with 25(OH)D levels ≤32 ng/ml from 32 centers in the Northeast United States were randomly assigned to oral ergocalciferol, 50,000 IU weekly (n=36) or monthly (n=33), or placebo (n=36) for a 12-week treatment period. The primary endpoint was the achievement of vitamin D sufficiency (25[OH]D >32 ng/ml) at the end of the 12-week treatment period. Survival was assessed through 1 year.
Results Baseline characteristics were similar across all arms, with overall mean ±SD 25(OH)D levels of 21.9±6.9 ng/ml. At 12 weeks, vitamin D sufficiency (25[OH]D >32 ng/ml) was achieved in 91% (weekly), 66% (monthly), and 35% (placebo) (P<0.001). Mean 25(OH)D was significantly higher in both the weekly (49.8±2.3 ng/ml; P<0.001) and monthly (38.3±2.4 ng/ml; P=0.001) arms compared with placebo (27.4±2.3 ng/ml). Calcium, phosphate, parathyroid hormone levels, and active vitamin D treatment did not differ between groups. All-cause and cause-specific hospitalizations and adverse events were similar between groups during the intervention period. Lower all-cause mortality among ergocalciferol-treated participants was not statistically significant (hazard ratio, 0.28; 95% confidence interval, 0.07 to 1.19).
Conclusions Oral ergocalciferol can increase 25(OH)D levels in incident hemodialysis patients without significant alterations in blood calcium, phosphate, or parathyroid hormone during a 12-week period.
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