Ovarian Cancer: Interplay of Vitamin D Signaling and miRNA Action. – 2014

Asian Pac J Cancer Prev. 2014;15(8):3359-62.
Attar R1, Gasparri ML, Donato VD, Yaylim I, Halim TA, Zaman F, Farooqi AA.

Increasing attention is being devoted to the mechanisms by which cells receive signals and then translate these into decisions for growth, death, or migration. Recent findings have presented significant breakthroughs in developing a deeper understanding of the activation or repression of target genes and proteins in response to various stimuli and of how they are assembled during signal transduction in cancer cells. Detailed mechanistic insights have unveiled new maps of linear and integrated signal transduction cascades, but the multifaceted nature of the pathways remains unclear. Although new layers of information are being added regarding mechanisms underlying ovarian cancer and how polymorphisms in VDR gene influence its development, the findings of this research must be sequentially collected and re-interpreted. We divide this multi-component review into different segments: how vitamin D modulates molecular network in ovarian cancer cells, how ovarian cancer is controlled by tumor suppressors and oncogenic miRNAs and finally how vitamin D signaling regulates miRNA expression. Intra/inter-population variability is insufficiently studied and a better understanding of genetics of population will be helpful in getting a step closer to personalized medicine.

PMID: 24870722

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See also VitaminDWiki

• See also VitaminDWiki "Ovarian Cancer" 190 items as of June 2014
• All items in category Cancer-Overian Vitamin D 26 items
• Ovarian Cancer 5.8 X more likely if both low vitamin D and Fok1 gene change – May 2013
• Ovarian cancer: more likely to survive if more vitamin D – Aug 2012 which has the following
  Survival rates for > or < 15 ng of vitamin D