Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis
Pharmacol Res . 2022 Oct 4;106484. doi: 10.1016/j.phrs.2022.106484
Elham Moslemi 1 , Vali Musazadeh 2 , Zeynab Kavyani 1 , Navid Naghsh 3 , Seyyed Morteza Seyyed Shoura 1 , Parvin Dehghan 4
Background: Vitamin D supplementation has attracted a lot of attention as a potential modulator of inflammation and oxidative stress, while some studies have reported controversial findings. In this regard, the purpose of this study was to summarize existing systematic reviews and meta-analyses of clinical trials that determined the effects of supplementation with vitamin D on inflammatory and oxidative biomarkers.
Methods: The following international databases were systematically searched till March 20th, 2022: PubMed, Scopus, Embase, Web of Science, and Google Scholar. A random-effects model was applied to evaluate the effects of vitamin D on inflammatory and oxidative stress biomarkers.
Results: Overall, 23 meta-analyses were qualified in this umbrella meta-analysis. Our findings revealed that the vitamin D supplementation significantly reduced
- serum C-reactive protein (CRP) (ES = -0.42; 95% CI: -0.55, -0.29, p <0.001),
- tumor necrosis factor-α (TNF-α) (ES = -0.27; 95% CI: -0.42, -0.12; p<0.001), and
- malondialdehyde (MDA) concentrations (ES = -0.37; 95% CI: -0.48, -0.25, p <0.001).
However, no significant changes were illustrated regarding
- interleukin-6 (IL-6) (ES = -0.35, 95% CI: -0.80, 0.10; p = 0.125),
- total antioxidant capacity (TAC) (ES = 0.68; 95% CI: -0.31, 1.66, p = 0.179), and
- glutathione (GSH) activity (ES = 0.08; 95% CI: -0.44, 0.60, p = 0.757).
Conclusion: The present umbrella meta-analysis indicated that supplementation of vitamin D in adults can improve CRP, TNF-α, and MDA levels under various health conditions. Vitamin D could be considered an adjuvant therapy for relieving inflammation and oxidative stress.
Inflammation Meta-analyses
- High-dose Vitamin D reduced inflammation and insulin resistance (obese children) - Dec 2023
- Inflammation markers reduced by Vitamin D - umbrella meta-analysis Oct 2022
- Eczema (Atopic Dermatitis) treated by 1,600 IU Vitamin D (again) – Meta-analysis Aug 2019
- Septic children have low Vitamin D (54 studies, ignored Vitamin D Receptor) – meta-analysis April 2019
- Diabetic inflammation reduced by Vitamin D – meta-analysis Feb 2018
- 2.7 fewer days in hospital after surgery if had taken Omega-3 (19 RCT) – meta-analysis – June 2017
- Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017
- Inflammation reduced when vitamin D supplementation raised level higher than 32 ng – meta-analysis May 2017
- Eczema (Atopic Dermatitis) treated by 1600 IU of vitamin D – meta-analysis Dec 2016
- Chronic Pancreatitis associated with painful bones (vitamin D) – meta-analysis July 2013
- Vitamin D and Respiratory Tract Infections – meta-analysis with charts June 2013
- Vitamin D reduces respiratory tract infections by 40 percent– meta-analysis Dec 2012
VitaminDWiki - Inflammation category contains
Example studies
- Vitamin D reduces autoimmune, cardio, and metabolic Inflammation – Nov 2024
- Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022
- COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT May 2021
- Inflammation (C-reactive protein) associated with low vitamin D in 22 diseases – April 2020
- Vitamin D reduces inflammation in critically ill patients – Sept 2020
- Inflammation is reduced by each of the following: Vitamin D, Omega-3, Diet
- How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
- CYTOKINE in VitaminDWiki 12 titles as of July 2023
- 17 pages in VitaminDWiki had REACTIVE or CRP in title as of July 2023
- Little risk of infection after surgery if have more than 50 ng of vitamin D - 2014
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